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Cell Cycle Control by Ataxia Telangiectasia Mutated Protein Through Regulating Retinoblastoma Protein Phosphorylation

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Tumors of the Central Nervous System, Volume 8

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 8))

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Abstract

The ability of cells to maintain their genomic integrity is essential to the prevention of cancer development. Double-strand breaks (DSBs), the most harmful type of lesion to DNA, are sensed by ataxia-telangiectasia mutated (ATM) protein in association with the MRE11-RAD50-NBS1 complex. The ATM kinase, which is mutated in ataxia-telangiectasia disorder, is a crucial guardian of genomic integrity. Its activation in response to DSBs orchestrates the DNA damage response (DDR) by phosphorylating a plethora of substrates that modulate processes such as DNA repair and cell cycle checkpoints. In this chapter we focus on the molecular mechanisms involved in ATM activation and cell cycle control in response to DSBs and, specifically, on the cross-talk between ATM and retinoblastoma protein (pRb) phosphorylation.

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Acknowledgments

This study was supported by grants from the Spanish Ministry of Education and Science SAF-2009-13093, BFU2010-19119 and BFU2010-22149 the Fondo de Investigación Sanitaria and the Instituto de Salud Carlos III (PI080400 and PS09/01789) (FEDER FOUNDS). We thank the Catalan Government (Generalitat de Catalunya) for supporting the research groups (2009/SGR00853). 610RT0405 from Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED). We thank the University of Barcelona Language Services for revising the manuscript.

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Authors and Affiliations

  1. Institut de Biomedicina, Facultat de farmàcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain

    Javier G. Pizarro, Antoni Camins, Felix Junyent & Mercè Pallàs

  2. Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, C./St. Llorenc, 21, 43201, Reus, Tarragona, Spain

    Felix Junyent & Jaume Folch

  3. Facultat de Biologia, Departament de Biologia Cellular, Universitat de Barcelona, Barcelona, Spain

    Ester Verdaguer & Carme Auladell

  4. Departamento de Biologia Celular y Molecular, Universidad de Guadalajara and Division de Neurociencias, Guadalajara, JAL, Mexico

    Carlos Beas-Zarate

  5. Centro de Investigacion biomedical de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, JAL, Mexico

    Carlos Beas-Zarate

Authors
  1. Javier G. Pizarro
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  2. Antoni Camins
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  3. Felix Junyent
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  6. Carlos Beas-Zarate
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  7. Mercè Pallàs
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  8. Jaume Folch
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Corresponding author

Correspondence to Javier G. Pizarro .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Pizarro, J.G. et al. (2012). Cell Cycle Control by Ataxia Telangiectasia Mutated Protein Through Regulating Retinoblastoma Protein Phosphorylation. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 8. Tumors of the Central Nervous System, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4213-0_11

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  • DOI: https://doi.org/10.1007/978-94-007-4213-0_11

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-4212-3

  • Online ISBN: 978-94-007-4213-0

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