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Midkine Gene Transfer in Brain Infarction

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Midkine: From Embryogenesis to Pathogenesis and Therapy

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Abstract

Cerebrovascular disease is the leading cause of death and disability in Japan and most Western countries. Gene transfer techniques may be applicable to the treatment of serious types of stroke, since several experimental studies have revealed the usefulness of gene therapy in the prevention of vasospasm after subarachnoid hemorrhage, reduction of infarct size and improvement of neuronal functions. Midkine is reported to have anti-apoptotic effects, and the gene transfer of midkine to the ischemic brain may provide neuroprotective effects. Furthermore, chemotactic effects of midkine could be utilized for the neurogenesis and functional recovery. We describe the novel possibility of the stroke treatment using midkine gene transfer.

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Acknowledgements

We would like to thank the University of Iowa Gene Transfer Vector Core, especially Beverly L. Davidson.

Author information

Authors and Affiliations

  1. Section of Internal Medicine, Department of Medicine, Fukuoka Dental College, Medical and Dental Hospital, 2-15-1 Tamura, Sawara-ku, Fukuoka, 814-0193, Japan

    Hiroaki Ooboshi

  2. Department of Medicine and Clinical Science, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Eiichi Ishikawa, Junichi Takada, Takashi Shichita & Yasuhiro Kumai

Authors
  1. Hiroaki Ooboshi
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  2. Eiichi Ishikawa
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  3. Junichi Takada
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  4. Takashi Shichita
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  5. Yasuhiro Kumai
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Corresponding author

Correspondence to Hiroaki Ooboshi .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Faculty of Biochemistry, Yeni Yüzyıl University, Yilanli Ayazma 26, Istanbul, 34000, Istanbul, Turkey

    Mine Ergüven

  2. , Department of Health Science, Aichi Gakuin University, 12 Araike, Iwasakicho, Nisshin, Aichi, Japan

    Takashi Muramatsu

  3. , Department of Histology and Embryology, Istanbul University Faculty of Medicine, Millet, Istanbul, Turkey

    Ayhan Bilir

Additional information

Funding: This work was supported by the Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (S0801084, 23591262), Tokyo, Japan.

Conflict of interest: None.

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Ooboshi, H., Ishikawa, E., Takada, J., Shichita, T., Kumai, Y. (2012). Midkine Gene Transfer in Brain Infarction. In: Ergüven, M., Muramatsu, T., Bilir, A. (eds) Midkine: From Embryogenesis to Pathogenesis and Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4234-5_13

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