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Primary Cilia and Brain Cancer

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Cilia and Nervous System Development and Function

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Abstract

Cell-extrinsic signals and intrinsic cell cycle regulators strictly control proliferation. Cancers develop from a cell that escapes these tight controls and proliferates unrestrictedly. The primary cilium critically controls proliferation by mediating cell-extrinsic signals and regulating cell cycle entry. Accordingly, recent studies showed that defective cilia can either promote or suppress cancers, depending on the cancer-initiating mutation, and that presence or absence of primary cilia is associated with specific cancer types. These novel findings suggest that primary cilia play central but distinct roles in different cancer types, opening up a completely new avenue of research to understand the biology and treatment of cancers.

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Acknowledgments

American Lebanese Syrian Associated Charities (Y.-G.H.) and the Cancer Center Support Grant CA021765 from the National Cancer Institute (Y.-G.H.) supported this work.

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Authors and Affiliations

  1. Division of Brain Tumor Research, Department of Developmental Neurobiology, Neurobiology and Brain Tumor Program, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Shirui Hou & Young-Goo Han

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  1. Shirui Hou
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  2. Young-Goo Han
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Correspondence to Young-Goo Han .

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Editors and Affiliations

  1. , Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, Heidelberg, 69120, Germany

    Kerry L. Tucker

  2. , Human Genetics, Emory University, Michael Street, Suite 301 615, Atlanta, 30322, Georgia, USA

    Tamara Caspary

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Hou, S., Han, YG. (2013). Primary Cilia and Brain Cancer. In: Tucker, K., Caspary, T. (eds) Cilia and Nervous System Development and Function. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5808-7_8

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