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Claudin-5 and Cancer Metastasis

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Tight Junctions in Cancer Metastasis

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 19))

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Abstract

The claudin family of proteins plays a critical role in the maintenance of epithelial and endothelial tight junctions, maintenance of the cytoskeleton and in cell signaling. While the exact functions of claudins in cancer cells are not fully understood, some studies suggest that claudins are involved in survival and invasion of cancer cells. Claudin-5, forming the backbone of tight junctions in blood vessels and lymphatic endothelial cells, has an important role in maintaining the homeostasis of the tissue microenvironment and tumors showing claudin-5 expression could have some additional affinity for blood vessels. Metastasis is a complex phenomenon that requires a number of specific steps such as decreased adhesion, increased motility and invasion, proteolysis, and resistance to apoptosis. Several studies about significance of claudin-5 expression in cancer cells were reported, suggesting that it may play an important role in regulation of metastasis, angiogenesis and tumor growth.

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Authors and Affiliations

  1. Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil

    Cláudia Malheiros Coutinho-Camillo & Fernando Augusto Soares

  2. Centro Internacional de Pesquisa e Ensino, Hospital AC Camargo, Rua Taguá, 440 – Primeiro andar, São Paulo, 01508-010, Brazil

    Cláudia Malheiros Coutinho-Camillo

  3. Discipline of General Pathology, Dental School, University of São Paulo, São Paulo, Brazil

    Silvia Vanessa Lourenço & Fernando Augusto Soares

  4. Av Prof Lineu Prestes, 2227, São Paulo, 05508-000, Brazil

    Silvia Vanessa Lourenço

Authors
  1. Cláudia Malheiros Coutinho-Camillo
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  2. Silvia Vanessa Lourenço
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  3. Fernando Augusto Soares
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Correspondence to Cláudia Malheiros Coutinho-Camillo .

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Editors and Affiliations

  1. Cardiff University, Institute of Cancer & Genetics, Heath Park, Cardiff, CF14 4XN, West Glamorgan, United Kingdom

    Tracey A. Martin

  2. Cardiff University, Institute of Cancer & Genetics, Heath Park, Cardiff, CF4 4XN, United Kingdom

    Wen G. Jiang

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Coutinho-Camillo, C.M., Lourenço, S.V., Soares, F.A. (2013). Claudin-5 and Cancer Metastasis. In: Martin, T., Jiang, W. (eds) Tight Junctions in Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6028-8_11

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