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Inhibition of Pancreatitis and Carcinogenesis by Capsaicin

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Role of Capsaicin in Oxidative Stress and Cancer

Part of the book series: Diet and Cancer ((DICA,volume 3))

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Abstract

Pancreatic cancer is one of the most lethal malignant neoplasms. The risk and prevention factors are strongly related to life and dietary style, environment, genetic factors, and genetic-environment interaction. Chronic pancreatitis is one of well-recognized risk factors for pancreatic cancer development. Fresh vegetables and fruits have been well documented having protective effect against inflammation and cancer development. Chili pepper is the fruit of plants from the genus Capsicum, and capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a colorless irritant phenolic amide, found in various capsicums that give the spicy taste. Epidemiologic and animal studies indicate that capsaicin is a highly potential agent in prophylaxis and treatment of diabetes, analgesic, inflammatory disease and cancer. This chapter focuses on linking capsaicin to pancreatitis and pancreatic carcinogenesis from experimental evidence to potential usefulness on prevention and treatment of this highly lethal malignant disease – pancreatic cancer.

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Acknowledgement

 This study is partially supported by grant from the National Institutes of Health, CA122514 and CA164041 to GYY and CA129038 and CA106953 to SKS.

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Authors and Affiliations

  1. Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA

    Wanying Zhang, Jie Liao, Haonan Li, Allison Yang & Guang-Yu Yang M.D., Ph.D.

  2. Department of Biomedical Sciences, Texas Tech University Health Sciences Center, 1406 Coulter Drive, Amarillo, TX, 79106, USA

    Sanjay K. Srivastava Ph.D.

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  1. Wanying Zhang
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  2. Jie Liao
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  3. Haonan Li
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  4. Allison Yang
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  5. Sanjay K. Srivastava Ph.D.
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  6. Guang-Yu Yang M.D., Ph.D.
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Correspondence to Sanjay K. Srivastava Ph.D. or Guang-Yu Yang M.D., Ph.D. .

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  1. , Biomedical Sciences, Texas Tech Univ. Health Sciences Center, Coulter Drive 1406, Amarillo, 79106, Texas, USA

    Sanjay K. Srivastava

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Zhang, W., Liao, J., Li, H., Yang, A., Srivastava, S.K., Yang, GY. (2013). Inhibition of Pancreatitis and Carcinogenesis by Capsaicin. In: Srivastava, S. (eds) Role of Capsaicin in Oxidative Stress and Cancer. Diet and Cancer, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6317-3_5

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  • DOI: https://doi.org/10.1007/978-94-007-6317-3_5

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