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Modulation of Proteasome Pathways by Nutraceuticals

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Cancer Chemoprevention and Treatment by Diet Therapy

Part of the book series: Evidence-based Anticancer Complementary and Alternative Medicine ((ACAM,volume 5))

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Abstract

The proteasome is a multicatalytic proteinase complex, the inhibition of which has been associated with induction of apoptosis, anti-tumorigenesis, and chemosensitization of tumor cells to the conventional chemotherapeutics agents and radiation. Therefore, inhibition of the proteasome pathway could be a novel approach for the prevention and treatment of cancer. Proteasome inhibitors mediate the antitumor effect through modulation of transcription factors, cell cycle regulatory proteins, and pro- and anti-apoptotic proteins. Although numerous proteasome inhibitors have been rationally designed, most of them not only are enormously expensive but also produce serious side effects. Currently, numerous nutraceuticals such as curcumin, sesamin, quercetin, silybinin, sulforaphane, resveratrol, tubocapsenolide A, CDDO-Me, γ-tocotrienol, apigenin, ferulic acid, betulinic acid, anacardic acid, genistein, withaferin A, emodin, withanolide, and gambogic acid derived from fruits, vegetables, spices, nuts, and legumes have shown promise as proteasome inhibitors, which may contribute to their anticancer activities. Although the mechanism of proteasome inhibition by nutraceuticals is different, it plays a crucial role against cancer. In this chapter, we discuss the targets of these nutraceuticals in the proteasome pathway. How inhibition of the proteasome pathway by these natural agents contributes to their anticancer activities is also discussed.

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Acknowledgements

We thank Luanne Jorewicz from the Department of Scientific Publications for carefully proofread the manuscript and provide valuable comments. Dr. Aggarwal is the Ransom Horne, Jr., Professor of Cancer Research. This work was supported by a grant from the Malaysian Palm Oil Board, Malaysia and a grant from Center for Targeted Therapy of MD Anderson Cancer Center.

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Authors and Affiliations

  1. Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA

    Sahdeo Prasad, Subash C. Gupta, Bokyung Sung & Bharat B. Aggarwal

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  1. Sahdeo Prasad
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  2. Subash C. Gupta
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  3. Bokyung Sung
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  4. Bharat B. Aggarwal
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Corresponding author

Correspondence to Bharat B. Aggarwal .

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Editors and Affiliations

  1. Dept. Clinical Oncology, Queen Elizabeth Hospital, Gascoigne Road 30, Kowloon, Hong Kong SAR

    William C.S. Cho

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© 2013 Springer Science+Business Media Dordrecht

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Prasad, S., Gupta, S.C., Sung, B., Aggarwal, B.B. (2013). Modulation of Proteasome Pathways by Nutraceuticals. In: Cho, W. (eds) Cancer Chemoprevention and Treatment by Diet Therapy. Evidence-based Anticancer Complementary and Alternative Medicine, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6443-9_9

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