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Non-CDH1-Associated Familial Gastric Cancer and Epigenetics Factors

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Spotlight on Familial and Hereditary Gastric Cancer

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Abstract

This chapter provides an overview of the major epigenetic mechanisms, such as DNA methylation, histone modifications, and miRNA, and describes those epigenetic mechanisms that are altered in non-CDH1 associated familial gastric cancer. Moreover, we also discuss the clinical implications of the epigenome characterization for this familial gastric cancer setting, regarding its potential in therapy.

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Abbreviations

CIN:

Chromosomal Instability

DNMT:

DNA Methyltransferase

HAT:

Histone Acethyltransferase

HDAC:

Histone Deacethylase

HDGC:

Hereditary Diffuse Gastric Cancer

HNPCC:

Hereditary Non-Polyposis Colorectal Cancer

miRNA:

microRNA

MSI:

Microsatellite Instability

MMR:

Mismatch Repair

PTM:

Post-Translational Modification

UTR:

Untranslated Region

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Acknowledgements 

This study was supported by the Portuguese Foundation for Science and Technology (Post-Doc grant to Marina Leite, reference SFRH/BPD/33420/2008). IPATIMUP is an Associate Laboratory of the Portuguese Ministry of Science, Technology and Higher Education and is partially supported by FCT, the Portuguese Foundation for Science and Technology.

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Authors and Affiliations

  1. Department of Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr Roberto Frias S/N, Porto, 4200-465, Portugal

    Marina Leite Ph.D., Sónia Sousa, Joana Carvalho Ph.D., Carla Oliveira Ph.D., Ceu Figueiredo Ph.D. & Raquel Seruca M.D., Ph.D.

  2. Section of General Surgery and Surgical Oncology, Department of Medical, Surgical Sciences and Neuroscience, University of Siena, Viale Bracci, Siena, 53100, Italy

    Giovanni Corso M.D., Ph.D. & Franco Roviello M.D.

  3. Faculty of Medicine, University of Porto, Porto, Portugal

    Carla Oliveira Ph.D. & Raquel Seruca M.D., Ph.D.

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  1. Marina Leite Ph.D.
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  2. Giovanni Corso M.D., Ph.D.
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  3. Sónia Sousa
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  4. Joana Carvalho Ph.D.
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  5. Franco Roviello M.D.
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  6. Carla Oliveira Ph.D.
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  7. Ceu Figueiredo Ph.D.
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  8. Raquel Seruca M.D., Ph.D.
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Correspondence to Marina Leite Ph.D. .

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Editors and Affiliations

  1. Dept. of Medical, Surgical Sciences, and Neurosciences, University of Siena, viale Bracci, Siena, 53100, Italy

    Giovanni Corso

  2. Dept. of Medical, Surgical Sciences, and Neurosciences, University of Siena, Via Banchi di Sotto 55, Siena, 53100, Italy

    Franco Roviello

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Leite, M. et al. (2013). Non-CDH1-Associated Familial Gastric Cancer and Epigenetics Factors. In: Corso, G., Roviello, F. (eds) Spotlight on Familial and Hereditary Gastric Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6570-2_10

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