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Metabolite Transporters of the Plant Peroxisomal Membrane: Known and Unknown

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Peroxisomes and their Key Role in Cellular Signaling and Metabolism

Part of the book series: Subcellular Biochemistry ((SCBI,volume 69))

Abstract

Tremendous progress in plant peroxisome research has revealed unexpected metabolic functions for plant peroxisomes. Besides photorespiration and lipid metabolism, plant peroxisomes play a key role in many metabolic and signaling pathways, such as biosynthesis of phytohormones, pathogen defense, senescence-associated processes, biosynthesis of biotin and isoprenoids, and metabolism of urate, polyamines, sulfite, phylloquinone, volatile benzenoids, and branched chain amino acids. These peroxisomal pathways require an interplay with other cellular compartments, including plastids, mitochondria, and the cytosol. Consequently, a considerable number of substrates, intermediates, end products, and cofactors have to shuttle across peroxisome membranes. However, our knowledge of their membrane passage is still quite limited. This review describes the solute transport processes required to connect peroxisomes with other cell compartments. Furthermore, we discuss the known and yet-to-be-defined transport proteins that mediate these metabolic exchanges across the peroxisomal bilayer.

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Abbreviations

AA:

Amino acid

AAE:

Acyl-activating enzyme

ABC:

ATP binding cassette

ABI5:

Abscisic acid-insensitive 5

APX:

Ascorbate peroxidase

ASC:

Ascorbate

ATP:

Adenosine triphosphate

BA:

Benzoic acid

BCAA:

Branched chain amino acid

β-ox:

β-oxidation

BZO1:

Benzoyl-CoA ligase

CHY1/DBR5:

Peroxisomal β-hydroxyisobutyryl-CoA hydrolase

CoA:

Coenzyme A

CTS:

COMATOSE (peroxisomal ABC transporter)

2,4-D:

Dichlorophenoxyacetic acid

DAR:

Dehydroascorbate reductase

2,4-DB:

2,4-dichlorophenoxybutyrate

D-2-HG:

D-2-hydroxyglutarate

DHNA:

1,4-dihydroxy-2-naphthoate

DiT2:

Glutamate/2-oxoglutarate translocator

DMAPP:

Dimethylallyl diphosphate

DOXP:

1-deoxy-D-xylulose-5-phosphate

FA:

Fatty acid

FFS:

Farnesyl diphosphate synthase

GAP:

Glycerinaldehyde 3-phosphate

Glu:

Glutamate

G6PD:

Glucose-6-phosphate dehydrogenase

GR:

Glutathione reductase

GSH:

Glutathione

GSSH:

Glutathione disulfide

H2O2 :

Hydrogen peroxide

IAA:

Indole acetic acid (auxin)

IBA:

Indole butyric acid

IDH:

Isocitrate dehydrogenase

IDI:

Isopentenyl diphosphate isomerase

IPP:

Isopentenyl diphosphate

JA:

Jasmonic acid

KAPA:

7-keto-8-amino-pelargonic acid

NAD:

Nicotinamide adenine dinucleotide

NADH:

Nicotinamide adenine dinucleotide reduced

NADP:

Nicotinamide adenine dinucleotide phosphate

NADPH:

Nicotinamide adenine dinucleotide phosphate reduced

NAT:

Nucleobase-ascorbate transport protein

NH4 + :

Ammonium

MDAR:

Monodehydroascorbate reductase

MVA:

Mevalonate

MVD:

Mevalonate diphosphate decarboxylase

OG:

2-oxoglutarate

OPC8:0:

3-oxo-2-(2′-[Z]-pentenyl)cyclopentane-1-octanoic acid

OPDA:

12-oxophytodienoic acid

OPPP:

Oxidative pentose phosphate pathway

PA:

Polyamine

PAL:

Phenylalanine ammonia lyase

PHYLLO:

Plastid multifunctional enzyme

6PGD:

6-phosphogluconate dehydrogenase

6PGL:

6-phosphogluconolactone

PMK:

Phosphomevalonate kinase

PMP22:

22 kDa peroxisomal membrane protein

PNC:

Peroxisomal ATP transport proteins

Pi :

Inorganic phosphate

PPase:

Pyrophosphatase

PPi:

Pyrophosphate

PT:

Plastidial phosphate translocator

PTS:

Peroxisomal targeting signal

PUT1:

Small aliphatic amine transporter

Pxmp2:

Peroxisomal membrane protein 2

PXN:

Peroxisomal NAD/CoA transport protein

Ru1.5BP:

Ribulose-1.5-bisphosphate

RNAi:

RNA interference

ROS:

Reactive oxygen species

SA:

Salicylic acid

SO:

Sulfite oxidase

TCA:

Tricarboxylic acid cycle

YFP:

Yellow fluorescent protein

XDH:

Xanthine dehydrogenase

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Acknowledgements

This work was supported by the DFG-grant 1781/1-1, 1781/2-1 and GRK 1525 (to Nicole Linka). The authors are grateful to Andreas P. M. Weber for helpful discussion. Many thanks to Kristin Bernhardt, Martin Schroers, Sarah K. Vigelius, Jan Wiese, and Thomas Wrobel for their commitments to elucidate the peroxisomal permeome in plants. Rothamsted Research receives grant-aided support from the BBSRC of the UK.

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  1. Department of Plant Biochemistry, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany

    Nicole Linka

  2. Biological Chemistry and Crop Protection Department, Rothamsted Research, Harpenden, AL5 2JQ, UK

    Frederica L. Theodoulou

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  1. Nicole Linka
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  2. Frederica L. Theodoulou
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Correspondence to Nicole Linka .

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  1. , Depto. Bioquímica, Biología Celular y, Estación Experimental del Zaidín, CSIC, Profesor Albareda 1, Granada, 18008, Spain

    Luis A. del Río

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Linka, N., Theodoulou, F.L. (2013). Metabolite Transporters of the Plant Peroxisomal Membrane: Known and Unknown. In: del Río, L. (eds) Peroxisomes and their Key Role in Cellular Signaling and Metabolism. Subcellular Biochemistry, vol 69. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6889-5_10

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