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Vibrational Spectroscopy: Disease Diagnostics and Beyond

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Optical Spectroscopy and Computational Methods in Biology and Medicine

Part of the book series: Challenges and Advances in Computational Chemistry and Physics ((COCH,volume 14))

Abstract

This chapter outlines some developments in the applications of vibrational spectroscopy for disease diagnostics and demonstrates how the applications of the spectroscopic techniques can be extended to the analysis and evaluation of disease aetiology and the mechanisms of interaction with and the cellular and subcellular responses to, for example, chemotherapeutic agents and nanoparticles. The primary emphasis is on Raman spectroscopy, although some examples are based on infrared absorption spectroscopy. The studies presented are chosen to illustrate how a range of multivariate analytical techniques can be employed to maximize the potential benefits of the complex spectral information obtained from tissue or cells.

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References

  1. http://coolcosmos.ipac.caltech.edu/cosmic_classroom/classroom_activities/herschel_bio.html

  2. Rieke GH (2009) History of infrared telescopes and astronomy. Exp Astron 25:125

    Article  Google Scholar 

  3. Smith AL (1979) Applied Infrared spectroscopy: fundamentals, techniques, and analytical problemsolving. Wiley, New York

    Google Scholar 

  4. Mertz L (1965) Astron J 70:548

    Google Scholar 

  5. Griffiths PR, Curbelo R, Foskett CT, Dunn ST (1970) Analytical instrumentation (Inst. Society of America), 8, II4 (1970)

    Google Scholar 

  6. Messerchmidt R, Harthcock M (eds) (1988) Infrared microscopy, theory and applications. Marcel Dekker, New York

    Google Scholar 

  7. http://www.mtholyoke.edu/~mlyount/MySites/ForensicSpectroscopy/ForensicApps.html

  8. USA Today, June 23rd 1993, pg8A

    Google Scholar 

  9. Lyon RC, Jefferson EH, Ellison CD, Buhse LF, Spencer JA, Nasr MM, Hussain AS Exploring Pharmaceutical Applications of NearInfrared Technology. American Pharmaceutical Review, http://americanpharmaceuticalreview.com/ViewArticle.aspx?ContentID=225

  10. Raman CV, Krishnan KS (1928) Nature 121:501

    Google Scholar 

  11. Adjouri C, Elliasmine A, Le Duff Y (1996) Spectroscopy 44:46

    Google Scholar 

  12. Puppels GJ, Olminkhof JHF, Segers-Nolten GMJ, Otto C, de Mul FFM, Greve J (1991) Exp Cell Res 195:361

    Google Scholar 

  13. Jackson M, Mantsch H (1995) CRC Crit Rev Biochem Mol Biol 30:95

    Google Scholar 

  14. Casal HL, Mantsch HH (1984) Biochim Biophys Acta 779:381

    Google Scholar 

  15. Mathlouthi M, Koenig JL (1986) Adv Carbohydr Chem Biochem 44:7

    Google Scholar 

  16. Taillandier E, Liquier J, Taboury JA (1985) In: Clark RJH, Hester RE (eds), Advances in spectroscopy: advances in infrared and Raman spectroscopy, vol 12. Wiley, New York, p 65

    Google Scholar 

  17. Wong P, Lacele S, Yadzi H (1993) Appl Spectroscopy 47:1830

    Google Scholar 

  18. Dukor R (2002) Vibrational spectroscopy in the detection of cancer. In: Chalmers JM, Griffiths PR (eds) Handbook of vibrational spectroscopy, vol 5. Wiley, Chichester

    Google Scholar 

  19. Gazi E, Baker M, Dwyer J, Lockyer NP, Gardner P, Shanks JH, Reeve RS, Hart C, Clarke NW, Brown M (2006) Eur Urol 50:750–761

    Google Scholar 

  20. Fernandez DC, Bhargava R, Hewitt SM, Levin IW (2005) Nature Biotechnol 23:469

    Google Scholar 

  21. Lord RC, Yu NT (1970) J Mol Biol 20:50924

    Google Scholar 

  22. Tobin MC (1998) Science 161:68

    Google Scholar 

  23. Walton AG, Deveney MJ, Koenig JL (1970) Calcified Tissue Int 6:162

    Google Scholar 

  24. Yu NT, Jo BH, Chang RCC, Huber JD (1974) Arch Biochem Biophys 160:614

    Google Scholar 

  25. Puppels GJ, Breve J (1996) Biomedical applications of spectroscopy. In: Clark RHJ, Hester RE (eds) Advances in spectroscopy, vol 25. Wiley, New York

    Google Scholar 

  26. Gniadecka M, Wulf HC, Nielsen OF, Christensen DH, Hercogova J (1997) Photochem Photobiol 66:418

    Google Scholar 

  27. Krishna CM, Sockalingum GD, Venteo L, Bhat RA, Kustagi P, Pluot M, Manfait M (2002) Biopolymers 5:269

    Google Scholar 

  28. Smith J, Kendall C, Sammon A, ChristieBrown J, Stone N (2003) Technol Cancer Res Treatment 2:327

    Google Scholar 

  29. Molckovsky A, Song LMWK, Shim MG, Marcon NE, Wilson BC (2003) Gastrointest Endosc 57:396

    Google Scholar 

  30. Hanlon EB, Manoharan R, Koo TW, Shafer KE, Motz JT, Fitzmaurice M, Kramer JR, Itzkan I, Dasari RR, Feld MS (2000) Phys Med Biol 45:R1–R59

    Google Scholar 

  31. Caspers PJ, Lucassen GW, Wolthuis R, Bruining HA, Puppels GJ (1999) Biospectroscopy 4:S31–39

    Google Scholar 

  32. Utzinger U, MahadevanJansen A, Hinzelman D, Follen M, Richards-Kortum R (2001) Appl Spectrosc 55:955

    Google Scholar 

  33. http://www.chem.neu.edu/web/faculty/Prof.MaxDiem.html

  34. Lyng FM, Faoláin EÓ, Conroy J, Meade A, Knief P, Duffy B, Hunter M, Byrne J, Kelehan P, Byrne HJ (2007) Exp Mol Pathol 82:121

    Google Scholar 

  35. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics 2002. CA Cancer J Clin 55:74–108

    Article  Google Scholar 

  36. Nanda K, McCrory DC, Myers ER, Bastian LA, Hasselblad V, Hickey JD, Matchar DB (2000) Ann Intern Med 132:810

    Google Scholar 

  37. Willis BH, Barton P, Pearmain P, Bryan S, Hyde C (2005) Health Technol Assess 9:1–207

    Google Scholar 

  38. Bolger N, Heffron C, Regan I, Sweeney M, Kinsella S, McKeown M, Creighton G, Russell J, O’Leary J (2006) Acta Cytol 50:483

    Google Scholar 

  39. Koliopoulos G, Arbyn M, Martin-Hirsch P, Kyrgiou M, Prendiville W, Paraskevaidis E (2006) Gynecol Oncol 104:232

    Google Scholar 

  40. Chang SK, Pavlova T, Marin N, Follen M, Richards-Kortum R (2005) Gynecol Oncol 99:S61–63

    Google Scholar 

  41. Gurjar RS, Backman V, Perelman LT, Georgakoudi I, Badizadegan K, Itzkan I, Dasari RR, Feld MS (2001) Nat Med 7:1245

    Google Scholar 

  42. Escobar PF, Belinson JL, White A, Shakhova NM, Feldchtein FI, Kareta MV, Gladkova ND (2004) Int J Gynecol Cancer 14:470

    Google Scholar 

  43. Zuluaga AF, Follen M, Boiko I, Malpica A, Richards-Kortum R (2005) Am J Obstet Gynecol 193:83

    Google Scholar 

  44. Carlson K, Pavlova I, Collier T, Descour M, Follen M, Richards-Kortum R (2005) Gynecol Oncol 99:S84

    Google Scholar 

  45. Wood BR, Chiriboga L, Yee H, Quinn MA, McNaughton D, Diem M (2003) Gynecol Oncol 93:59

    Google Scholar 

  46. Mordechai S, Sahu RK, Hammody Z, Mark S, Kantarovich K, Guterman H, Podshyvalov A, Goldstein J, Argov S (2004) J Microscopy-Oxford 215:86

    Google Scholar 

  47. Romeo M, Matthaus C, Miljkovic M, Diem M (2004) Biopolymers 74:168

    Google Scholar 

  48. Mahadevan-Jansen A, Ramanujam N, Malpica A, Thomsen S, Utzinger U, Richards-Kortum R (1998) Photochem Photobiol 68:123

    Google Scholar 

  49. Faoláin EÓ, Hunter MB, Byrne JM, Kelehan P, Lambkin HA, Byrne HJ, Lyng FM (2005) J Histochem Cytochem 53:121

    Google Scholar 

  50. Jackson JE (1991) A user’s guide to principal components. Wiley, New York

    Book  Google Scholar 

  51. Otto M (1999) Chemometrics: statistics and computer applications in analytical chemistry. Wiley, New York

    Google Scholar 

  52. Crow P, Molckovsky A, Stone N, Uff J, Wilson B, Wong-KeeSong LM (2005) Urology 65:1126

    Google Scholar 

  53. Haka AS, Shafer-Peltier KE, Fitzmaurice M, Crowe J, Dasari RR, Feld MS (2002) Cancer Res 62:5375

    Google Scholar 

  54. Nijssen A, Bakker Schut TC, Heule F, Caspers PJ, Hayes DP, Neumann MH, Puppels GJ (2002) J Invest Dermatol 119:64

    Google Scholar 

  55. UK Patent Application No. GB0823071.6 (2008) A diagnostic instrument for cervical cancer screening. (December 2008)

    Google Scholar 

  56. International Patent, Lyng FM, Byrne HJ, Faoláin EÓ, Clarke C, Ostrowska KM (2010) A diagnostic instrument for cervical cancer screening. Patent no WO2010070133

    Google Scholar 

  57. Almond ML, Hutchings J, Kendall C, Stone N, Barr H (2011) Brit J Surg 98:35

    Google Scholar 

  58. Bassan P, Byrne HJ, Bonnier F, Lee J, Dumas P, Gardner P (2009) Analyst 134:1586

    Google Scholar 

  59. Bassan P, Byrne HJ, Lee J, Bonnier F, Clarke C, Dumas P, Gazi E, Brown MD, Clarke NW, Gardner P (2009) Analyst 134:1171

    Google Scholar 

  60. Bassan P, Kohler A, Martens H, Lee J, Byrne HJ, Dumas P, Gazi E, Brown M, Clarke N, Gardner P (2010) Analyst 135:268

    Google Scholar 

  61. Bonnier F, Mehmood A, Knief P, Meade A, Hornebeck W, Lambkin H, Flynn K, McDonagh V, Healy C, Lee TC, Lyng FM, Byrne HJ (2011) J Raman Spectrosc 42:888

    Google Scholar 

  62. Bonnier F, Ali SM, Knief P, Lambkin H, Flynn K, McDonagh V, Healy C, Lee TC, Lyng FM, Byrne HJ (2012) Vib Spectrosc 61:124

    Google Scholar 

  63. Ostrowska KM, Malkin A, Meade AD, O’Leary J, Martin C, Spillane C, Byrne HJ, Lyng FM (2010) Analyst 135:3087

    Google Scholar 

  64. Ostrowska KM, Garcia A, Meade AD, Malkin A, Okewumi I, O’Leary JJ, Martin C, Byrne HJ, Lyng FM (2011) Analyst 136:1365

    Google Scholar 

  65. Cuschieri KS, Cubie HA, Whitley MW, Gilkison G, Arends MJ, Graham C, McGoogan E (2005) J Clin Pathol 58:946

    Google Scholar 

  66. Tjalma WA, Van Waes TR, Van den Eeden LE, Bogers JJ (2005) Best Pract Res Clin Obstet Gynaecol 19:469

    Google Scholar 

  67. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ, Munoz N (1999) J Pathol 189:12

    Google Scholar 

  68. Mayrand MH, Duarte-Franco E, Rodrigues I, Walter SD, Hanley J, Ferenczy A, Ratnam S, Coutlee F, Franco EL (2007) N Engl J Med 357:1579

    Google Scholar 

  69. Jess PR, Smith DD, Mazilu M, Dholakia K, Riches AC, Herrington CS (2007) Int J Cancer 121:2723

    Google Scholar 

  70. Kelly JG, Cheung KT, Martin C, O’Leary JJ, Prendiville W, Martin-Hirsch PL, Martin FL (2010) Clin Chim Acta 411:1027

    Google Scholar 

  71. Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM, McGuinness E, Sheils O, O’Leary JJ (2005) J Clin Pathol 58:525

    Google Scholar 

  72. Max JJ, Chapados C (2009) J Chem Phys 131:184505

    Google Scholar 

  73. Martin CM, Kehoe L, Spillane CO, O’Leary JJ (2007) Mol Diagn Ther 11:277

    Google Scholar 

  74. Kalof A, Evans M, Simmons-Arnold L, Beatty B, Cooper K (2005) Am J Surg Pathol 29:674

    Google Scholar 

  75. Dray M, Russell P, Dalrymple C, Wallman N, Angus G, Leong A, Carter J, Cheerala B (2005) Pathology 37:112

    Google Scholar 

  76. Yu T, Ferber MJ, Cheung TH, Chung TK, Wong YF, Smith DI (2005) Cancer Genet Cytogenet 158:27

    Google Scholar 

  77. Ozgul N, Cil A, Bozdayi G, Usubutun A, Bulbul D, Rota S, Kose M, Biri A, Haberal A (2008) J Obstet Gynaecol Res 34:865

    Google Scholar 

  78. Murphy N, Ring M, Heffron C, King B, Killalea A, Hughes C, Martin C, McGuinness E, Sheils O, O’Leary J (2005) J Clin Pathol 58:525

    Google Scholar 

  79. Missaoui N, Hmissa S, Frappart L, Trabelsi A, Ben Abdelkader A, Traore C, Mokni M, Yaacoubi MT, Korbi S (2006) Virchows Arch 448:597

    Google Scholar 

  80. Murphy N, Ring M, Killalea AG, Uhlmann V, O’Donovan M, Mulcahy F, Turner M, McGuinness E, Griffin M, Martin C, Sheils O, O’Leary JJ (2003) J Clin Pathol 56:56

    Google Scholar 

  81. Klaes R, Friedrich T, Spitkovsky D, Ridder R, Rudy W, Petry U, Dallenbach-Hellweg G, Schmidt D, von Knebel Doeberitz M (2001) Int J Cancer 92:276

    Google Scholar 

  82. Agoff SN, Lin P, Morihara J, Mao C, Kiviat NB, Koutsky LA (2003) Mod Pathol 16:665

    Google Scholar 

  83. Murphy N, Heffron CC, King B, Ganuguapati UG, Ring M, McGuinness E, Sheils O, O’Leary JJ (2005) Virchows Arch 445:610

    Google Scholar 

  84. Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM, McGuinness E, Sheils O, O’Leary JJ (2005) J Clin Pathol 58:525

    Google Scholar 

  85. Wang SS, Trunk M, Schiffman M, Herrero R, Sherman ME, Burk RD, Hildesheim A, Bratti MC, Wright T, Rodriguez AC, Chen S, Reichert A, von Knebel Doeberitz C, Ridder R, von Knebel Doeberitz M (2004) Cancer Epidemiol Biomarkers Prev 13:1355

    Google Scholar 

  86. Movasaghi Z, Rehman S, Rehman IU (2007) Appl Spectrosc Rev 42:493

    Google Scholar 

  87. Black JW, Leff P (1983) Proc R Soc Lond B Biol Sci 220:141

    Google Scholar 

  88. Lizard G, Chignol MC, Chardonnet Y, Souchier C, Bordes M, Schmitt D, Revillard JP (1993) J Immunol Methods 157:31

    Google Scholar 

  89. Mehés G, Speich N, Bollmann M, Bollmann R (2004) Pathol Oncol Res 10:142

    Google Scholar 

  90. Burd EM (2003) Clin Microbiol Rev 16:1

    Google Scholar 

  91. Neviliappan S, Fang Kan L, Tiang Lee Walter T, Arulkumaran S, Wong PT (2002) Gynecol Oncol 85:170

    Google Scholar 

  92. Yazdi HM, Bertrand MA, Wong PT (1996) Acta Cytol 40:664

    Google Scholar 

  93. Suprynowicz FA, Disbrow GL, Krawczyk E, Simic V, Lantzky K, Schlegel R (2008) Oncogene 27:1071

    Google Scholar 

  94. Wong PT, Wong RK, Caputo TA, Godwin TA, Rigas B (1991) Proc Natl Acad Sci USA 88:10988

    Google Scholar 

  95. Martens H, Martens M (2000) Food Qual Prefer 11:5

    Google Scholar 

  96. Westad F, Martens H (2000) J Near Infrared Spectrosc 8:117

    Google Scholar 

  97. Doorbar J (2006) Clin Sci (Lond) 110:525

    Google Scholar 

  98. Nawaz H, Bonnier F, Knief P, Howe O, Lyng FM, Meade AD, Byrne HJ (2010) Analyst 135:3070

    Google Scholar 

  99. Nawaz H, Bonnier F, Meade AD, Lyng FM, Byrne HJ (2011) Analyst 136:2450

    Google Scholar 

  100. Owen CA, Selvakumaran J, Notingher I, Jell G, Hench LL, Stevens MM (2006) J Cell Biochem 99:178

    Google Scholar 

  101. Draux F, Jeannesson P, Beljebbar A, Tfayli A, Fourre N, Manfait M, Sule-Suso J, Sockalingum GD (2009) Analyst 134:542

    Google Scholar 

  102. Ling J, Weitman SD, Miller MA, Moore RV, Bovik AC (2002) Appl Opt 41:6006

    Google Scholar 

  103. Ling JY, Yang QZ, Luo SS, Li Y, Zhang CK (2005) Chin Chem Lett 16:71

    Google Scholar 

  104. Notingher I, Green C, Dyer C, Perkins E, Hopkins N, Lindsay C, Hench LL (2004) J R Soc Interface 1:79

    Google Scholar 

  105. Verrier S, Notingher I, Polak JM, Hench LL (2004) Biopolymers 157

    Google Scholar 

  106. Yang Y, Sule-Suso J, Sockalingum GD, Kegelaer G, Manfait M, El Haj AJ (2005) Biopolymers 78:311

    Google Scholar 

  107. Kosmider B, Wojcik I, Osiecka R, Bartkowiak J, Zyner E, Ochocki J, Liberski P (2005) Invest New Drugs 23:287

    Google Scholar 

  108. Vrana O, Masek V, Drazan V, Brabec V (2007) J Struct Biol 159:1

    Google Scholar 

  109. Ulukaya E, Ozdikicioglu F, Oral AY, Demirci M (2008) Toxicol In Vitro 22:232

    Google Scholar 

  110. Cordes N, Beinke C, Plasswilm L, van Beuningen D (2004) Strahlenther Onkol 180:157

    Google Scholar 

  111. Baik MH, Friesner RA, Lippard SJ (2003) J Am Chem Soc 125:14082

    Google Scholar 

  112. Dunham SU, Turner CJ, Lippard SJ (1998) J Am Chem Soc B:5395

    Google Scholar 

  113. Gelasco A, Lippard SJ (1998) Biochemistry 37:9230

    Google Scholar 

  114. Takahara PM, Rosenzweig AC, Frederick CA, Lippard SJ (1995) Nature 377:649

    Google Scholar 

  115. Meade AD, Clarke C, Byrne HJ, Lyng FM (2010) Radiat Res 173:225

    Google Scholar 

  116. Varmuza K, Filzmoser P (2009) Introduction to multivariate statistical analysis in chemometrics. CRC Press, Taylor and Francis Group, Boca Raton

    Book  Google Scholar 

  117. Krishna CM, Kegelaer G, Adt I, Rubin S, Kartha VB, Manfait M, Sockalingum GD (2006) Biopolymers 82:462

    Google Scholar 

  118. Le Gal JM, Morjani H, Manfait M (1993) Cancer Res 53:3681

    Google Scholar 

  119. Bonnier F, Meade AD, Merzha S, Knief P, Bhattacharya K, Lyng FM, Byrne HJ (2010) Analyst 135:1697

    Google Scholar 

  120. Fu Y, Wang H, Shi R, Cheng J-X (2007) Biophys J 92:3251

    Google Scholar 

  121. Colella G, Marchini S, D’Incalci MD, Brown R, Broggini M (1999) Br Cancer J 80:338

    Google Scholar 

  122. Bonnier F, Knief P, Lim B, Meade AD, Dorney J, Bhattacharya K, Lyng FM, Byrne HJ (2010) Analyst 135:3169

    Google Scholar 

  123. Notingher I, Verrier S, Haque S, Polak JM, Hench LL (2003) Biopolymers 72:230

    Google Scholar 

  124. Notingher I, Hench LL (2006) Expert Rev Med Devices 3:215

    Google Scholar 

  125. Puppels GJ, de Mul FF, Otto C, Greve J, Robert-Nicoud M, Arndt-Jovin DJ, Jovin TM (1990) Nature 347:301

    Google Scholar 

  126. Puppels GJ, Garritsen HS, Segers-Nolten GM, de Mul FF, Greve J (1991) Biophys J 60:1046

    Google Scholar 

  127. Miljkovic M, Chernenko T, Romeo MJ, Bird B, Matthaus C, Diem M (2010) Analyst 135:2002

    Google Scholar 

  128. Uzunbajakava N, Lenferink A, Kraan Y, Willekens B, Vrensen G, Greve J, Otto C (2003) Biopolymers 72:1

    Google Scholar 

  129. Draux F, Gobinet C, Sule-Suso J, Trussardi A, Manfait M, Jeannesson P, Sockalingum GD (2010) Anal Bioanal Chem 397:2727

    Google Scholar 

  130. Meade AD, Clarke C, Draux F, Sockalingum GD, Manfait M, Lyng FM, Byrne H (2010) J Anal Bioanal Chem 396:1781

    Google Scholar 

  131. Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ (1995) Semin Cancer Biol 6:175

    Google Scholar 

  132. Petersen OW, Ronnov-Jessen L, Howlett AR, Bissell MJ (1992) Proc Natl Acad Sci USA 89:9064

    Google Scholar 

  133. Prestwich GD (2008) Acc Chem Res 41:139

    Google Scholar 

  134. Smalley KS, Lioni M, Herlyn M (2006) In Vitro Cell Dev Biol: Anim 42:242

    Google Scholar 

  135. Curtis A, Wilkinson C (1997) Biomaterials 18:1573

    Google Scholar 

  136. Giannakakou P, Nakano M, Nicolaou KC, O’Brate A, Yu J, Blagosklonny MV, Greber UF, Fojo T (2002) Proc Natl Acad Sci USA 99:10855

    Google Scholar 

  137. Kotorashvili A, Russo SJ, Mulugeta S, Guttentag S, Beers MF (2009) J Biol Chem 284:16667

    Google Scholar 

  138. Hsia TC, Yang JS, Chen GW, Chiu TH, Lu HF, Yang MD, Yu FS, Liu KC, Lai KC, Lin CC, Chung JG (2009) Anticancer res 29:309

    Google Scholar 

  139. Pettus BJ, Bielawska A, Subramanian P, Wijesinghe DS, Maceyka M, Leslie CC, Evans JH, Freiberg J, Roddy P, Hannun YA, Chalfant CE (2004) J Biol Chem 279:11320

    Google Scholar 

  140. Grewal S, Ponnambalam S, Walker JH (2003) J Cell Sci 116:2303

    Google Scholar 

  141. MacQueen JB (1967) Proceedings of 5th Berkeley Symposium on Mathematical Statistics and Probability

    Google Scholar 

  142. Koljenovic S, Bakker Schut TC, van Meerbeeck JP, Maat AP, Burgers SA, Zondervan PE, Kros JM, Puppels GJ (2004) J Biomed Opt 9:1187

    Google Scholar 

  143. Lasch P, Haensch W, Naumann D, Diem M (2004) Biochimica et Biophysica Acta 1688:176

    Google Scholar 

  144. Ly E, Piot O, Durlach A, Bernard P, Manfait M (2009) Analyst 134:1208

    Google Scholar 

  145. Hedegaard M, Krafft C, Ditzel HJ, Johansen LE, Hassing S, Popp J (2010) Anal Chem 82:2797

    Google Scholar 

  146. Taleb A, Diamond J, McGarvey JJ, Beattie JR, Toland C, Hamilton PW (2006) J Phys Chem 110:19625

    Google Scholar 

  147. Short KW, Carpenter S, Freyer JP, Mourant JR (2005) Biophys J 88:4274

    Google Scholar 

  148. Swain RJ, Jell G, Stevens MM (2008) J Cell Biochem 104:1427

    Google Scholar 

  149. Krishna CM, Sockalingum GD, Venteo L, Bhat RA, Kushtagi P, Pluot M, Manfait M (2005) Biopolymers 79:269

    Google Scholar 

  150. Bonnier F, Byrne HJ (2012) Analyst 137:322

    Google Scholar 

  151. Dorney J, Bonnier F, Garcia A, Casey A, Chambers G, Byrne HJ (2012) Analyst 137:1111

    Google Scholar 

  152. Berntsen P, Park CY, Rothen-Rutishauser B, Tsuda A, Sager TM, Molina RM, Donaghey TC, Alencar AM, Kasahara DI, Ericsson T, Millet EJ, Swenson J, Tschumperlin DJ, Butler JP, Brain JD, Fredberg JJ, Gehr P, Zhou EH (2010) J R Soc Interface 7:S331

    Google Scholar 

  153. Lundqvist M, Stigler J, Elia G, Lynch I, Cedervall T, Dawson KA (2008) Proc Natl Acad Sci U.S.A. 105:14265

    Article  CAS  Google Scholar 

  154. Clift MJD, Rothen-Rutishauser B, Brown DM, Duffin R, Donaldson K, Proudfoot L, Guy K, Stone V (2008) Toxicol Appl Pharmacol 232:418

    Google Scholar 

  155. Rejman J, Oberle V, Zuhorn IS, Hoekstra D (2004) Biochem J 377:159

    Google Scholar 

  156. Rothen-Rutishauser B, Muhlfeld C, Blank F, Musso C, Gehr P (2007) Part Fibre Toxicol 4:9

    Google Scholar 

  157. Naha PC, Bhattacharya K, Tenuta T, Dawson KA, Lynch I, Garcia A, Lyng FM, Byrne HJ (2010) Toxicol Lett 198:134

    Google Scholar 

  158. Roy I, Ohulchanskyy TY, Bharali DJ, Pudavar HE, Mistretta RA, Kaur N. Prasad PN (2005) Proc Natl Acad Sci USA 102:279

    Google Scholar 

  159. Cang H, Xu CS, Montiel D, Yang H (2007) Opt Lett 32:2729

    Google Scholar 

  160. Salvati A, Aberg C, Dos Santos T, Varela J, Pinto P, Lynch I, Dawson KA (2011) Nanomedicine 7:818

    Google Scholar 

  161. Suh H, Jeong B, Liu F, Kim SW (1998) Pharm Res 15:1495

    Google Scholar 

  162. Yin Win K, Feng S-S (2005) Biomaterials 26:2713

    Google Scholar 

  163. Davoren M, Herzog E, Casey A, Cottineau B, Chambers G, Byrne HJ, Lyng FM (2007) Toxicol in Vitro 21:438

    Google Scholar 

  164. Shapero K, Fenaroli F, Lynch I, Cottell DC, Salvati A, Dawson KA (2011) Mol BioSyst 7:371

    Google Scholar 

  165. Knief P, Clarke C, Herzog E, Davoren M, Lyng FM, Meade AD, Byrne HJ (2009) Analyst 134:1182

    Google Scholar 

  166. Kneipp K, Haka AS, Kneipp H, Badizadegan K, Yoshizawa N, Boone C, Shafer-Peltier KE, Motz JT, Dasari RR, Feld MS (2002) Appl Spectrosc 56:150

    Google Scholar 

  167. Kneipp J, Kneipp H, McLaughlin M, Brown D, Kneipp K (2006) Nano Lett 6:2225

    Google Scholar 

  168. Kneipp J, Kneipp H, Rajadurai A, Redmond RW, Kneipp K (2009) J Raman Spectrosc 40:1

    Google Scholar 

  169. Kneipp J, Kneipp H, Rice WL, Kneipp K (2005) Anal Chem 77:2381

    Google Scholar 

  170. Kneipp J, Kneipp H, Wittig B, Kneipp K (2010) J Phys Chem C 114:7421

    Google Scholar 

  171. Nel AE, Madler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, Klaessig F, Castranova V, Thompson M (2009) Nat Mater 8:543

    Google Scholar 

  172. Chang MY, Shiau AL, Chen YH, Chang CJ, Chen HH, Wu CL (2008) Cancer Sci 99:1479

    Google Scholar 

  173. Hedegaard M, Matthaus C, Hassing S, Krafft C, Diem M. Popp J (2011) Theor Chem Acc 130:1249

    Google Scholar 

  174. Miljković M, Chernenko T, Romeo MJ, Bird B, Matthäus C, Diem M (2010) Analyst 135:2002

    Google Scholar 

  175. Keating ME, Bonnier F, Byrne HJ, (2012) Analyst DOI: 10.1039/c2an36169h

    Google Scholar 

  176. http://www.dasim.eu/website.php

  177. Benevolo M, Mottolese M, Marandino F, Vocaturo G, Sindico R, Piperno G, Mariani L, Sperduti I, Canalini P, Donnorso RP, Vocaturo A (2006) Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions. Mos Pathol 19:384–391

    Google Scholar 

  178. Passamonti B, Gustinucci D, Recchia P, Bulletti S, Carlani A, Cesarini E, D’Amico MR, D’Angelo V, Di Dato E, Martinelli N, Malaspina M, Spita N (2010) Expression of p16 in abnormal pap-tests as an indicator of CIN2+ lesions: a possible role in the low grade ASC/US and L/SIL (Ig) cytologic lesions for screening prevention of uterine cervical tumours. Pathologica 102:6–11

    Google Scholar 

  179. Negri G, Bellisano G, Zannoni GF, Rivasi F, Kasal A, Vittadello F, Antoniazzi S, Faa G, Ambu R, Egarter-Vigl E (2008) p16 ink4a and HPV L1 immunohistochemistry is helpful for estimating the behavior of low-grade dysplastic lesions of the cervix uteri. Am J Surg Pathol 32:1715–1720

    Google Scholar 

  180. Focchi GR, Silva ID, Nogueira-de-Souza NC, Dobo C, Oshima CT, Stavale JN (2007) Immunohistochemical expression of p16(INK4A) in normal uterine cervix, nonneoplastic epithelial lesions, and low-grade squamous intraepithelial lesions. J Low Genit Tract Dis 11:98–104

    Google Scholar 

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Authors and Affiliations

  1. Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland

    Hugh J. Byrne, Kamila M. Ostrowska, Haq Nawaz, Jennifer Dorney, Aidan D. Meade, Franck Bonnier & Fiona M. Lyng

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  1. Hugh J. Byrne
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  2. Kamila M. Ostrowska
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Correspondence to Hugh J. Byrne .

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  1. Faculty of Chemistry, Jagiellonian University, Ingardena 3, Krakow, Poland

    Malgorzata Baranska

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Byrne, H. et al. (2014). Vibrational Spectroscopy: Disease Diagnostics and Beyond. In: Baranska, M. (eds) Optical Spectroscopy and Computational Methods in Biology and Medicine. Challenges and Advances in Computational Chemistry and Physics, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7832-0_13

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