Skip to main content
SpringerLink
Log in

Interleukin 10 and non Hodgkin’s lymphomas

  • Chapter
Cancer in Transplantation: Prevention and Treatment

Part of the book series: Transplantation and Clinical Immunology ((TRAC,volume 27))

Abstract

Interleukin 10 (IL- 10) is a pleiotropic cytokine which plays a central role in several physiological and pathological processes, in particular in infectious diseases and cancer. IL-10 was initially described in three different reports, as cytokine synthesis inhibitory factor (CSIF) which inhibits the production of Th1 derived cytokine [1, 2], as a thymocyte growth factor produced by B lymphoma cells [3] and as a mast cell growth factor [4]. IL-10 regulates the survival, proliferation and differentiation of T, B lymphocytes and monocyte macrophages, and modulates bone formation and erythropoiesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fiorentino DF, Bond MW, Mosman TR: Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170: 2081.

    Article  PubMed  CAS  Google Scholar 

  2. Vieira P, de Waal-Malefyt R, Dang MN, et al. Isolation and expression of human cytokine synthesis inhibitory factor (CSIF/IL10) cDNA clones: homology to Epstein-Barr virus open reading frame BCRF1. Proc Natl Acad Sci USA 1991; 88: 1172–76.

    Article  PubMed  CAS  Google Scholar 

  3. Suda T, O’Garra A, MacNeil I, et al. Identification of a novel thymocyte growth promoting factor derived from B cell lymphomas Cell Immunol 1990; 129: 228–40.

    Article  PubMed  CAS  Google Scholar 

  4. O’Garra A, Stapleton G, Dhar V, et al. Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10. Int Immunol 1990; 2: 821–32.

    Article  PubMed  Google Scholar 

  5. Tan JC, Indelicato S, Narula SK, et al. Characterisation of IL-10 receptors on human and mouse cells. J Biol Chem 1993; 268: 21053–59.

    PubMed  CAS  Google Scholar 

  6. Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW. Expression cloning and characterization of a human IL-10 receptor. J Immunol 1994; 152: 1821–1829.

    PubMed  CAS  Google Scholar 

  7. Ho AS-Y, Liu Y, Khan TA, et al. A receptor for IL-10 is related to interferon receptors. Proc Natl Acad Sci USA 1993; 90: 11267–11271.

    Article  PubMed  CAS  Google Scholar 

  8. Moore KW, Ho AS-Y, Xu-Amano J. Molecular biology of interleukin 10 and its receptor. In: JE deVries, R de Wall Malefyt eds. Molecular Biology Intelligence Unit. Interleukin 10. RGLandes, 1995: 1–6.

    Google Scholar 

  9. Hsu DH, de Waal Malefyt R, Fiorentino DF, et al Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Science 1990; 250: 830–832, 1990.

    Article  PubMed  CAS  Google Scholar 

  10. de Waal Malefyt R, Haanen J, Spits H, et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen specific human T cell proliferation by diminishing the antigen- presenting capacity of monocytes via downregulation of class II Major Histocompatibility Complex expression. J Exp Med 1991; 174: 915–924.

    Article  PubMed  Google Scholar 

  11. De Waal Malefyt R, Figdor CG, Huijbens R, et al. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFNg or IL-10. J Immunol 1993; 151: 6370–6381.

    PubMed  Google Scholar 

  12. Ding L, Linsley PS, Huang LY, et al. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the upregulation of B7 expression. J Immunol 1993; 151: 1224–1234.

    PubMed  CAS  Google Scholar 

  13. Willems F, Marchant A, Delville JP, et al. IL-10 inhibits B7 and intercellular adhesion molecule 1 expression on human monocyte. Eur J Immunol 1994; 24: 1007–1009.

    Article  PubMed  CAS  Google Scholar 

  14. Kubin M, Kamoun M, Trinchieri G. IL-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J Exp Med 1994; 180: 211–222.

    Article  PubMed  CAS  Google Scholar 

  15. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209.

    Article  PubMed  Google Scholar 

  16. Ralph P, Nakoinz I, Sampson JA, et al. IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and TNF. J Immunol 1993; 151: 5574–5585.

    Google Scholar 

  17. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O’Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991; 147: 3815.

    PubMed  CAS  Google Scholar 

  18. D’Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993; 178: 1041–1048.

    Article  PubMed  Google Scholar 

  19. Bogdan C, Vodovotz Y, Nathan C. Macrophage deactivation by IL-10. J Exp Med 1991; 1549–1555.

    Google Scholar 

  20. Gazzinelli RT, Oswald JP, James SL, et al. IL-10 inhibits parasite killing and NO production by IFNg activated macrophages. J Immunol 1992; 148: 1792–1796.

    PubMed  CAS  Google Scholar 

  21. Oswald IP, Wynn TA, Sher A, et al. IL-10 inhibits macrophage microbicidal activity by blocking the endogenous production of TNF required as a costimulatory factor for IFNg- induced activation. Proc Natl Acad Sci USA 1992; 89: 8676–8680.

    Article  PubMed  CAS  Google Scholar 

  22. DeWaal Malefyt Figdor C, deVries JE. Regulation of human monocyte function by IL-10. In: JE deVries, R de Wall Malefyt eds. Molecular Biology Intelligence Unit. Interleukin 10. RGLandes 1995: 37–52.

    Google Scholar 

  23. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263–274.

    Article  PubMed  CAS  Google Scholar 

  24. Gerard C, Bruyns C, Marchant A, et al. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993; 177: 547–552.

    Article  PubMed  CAS  Google Scholar 

  25. Marchant A, Deviere J, Byl B, De Groote D, Vincent JL, Goldman M. Interleukin-10 production during septicaemia. Lancet 1994; 343: 707–709.

    Article  PubMed  CAS  Google Scholar 

  26. Del Prete G, De Carli M, Almerigogna F, Giudizi MG, Biagiotti R, Romagnani S. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993; 150: 353–360.

    PubMed  Google Scholar 

  27. Yssel H, DeWaal Malefyt R. IL-10 and human T cells. In: JE deVries, R de Wall Malefyt eds. Molecular Biology Intelligence Unit. Interleukin 10. RG Landes 1995: 19–27.

    Google Scholar 

  28. Saed G, Fivenson DP, Naidu Y, Nickoloff BJ. Mycosis fungoides exhibits a Th1-type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2-type profile. J Invest Dermatol 1994; 103: 29–33.

    Article  PubMed  CAS  Google Scholar 

  29. DeWaal Malefyt R, Yssel H, de Vries JE. Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells: specific inhibition of IL-2 production and proliferation. J Immunol 1993; 150: 4754–4765.

    CAS  Google Scholar 

  30. Taga K, Mostowski H, Tosato G. Human interleukin-10 can directly inhibit T-cell growth. Blood 1993; 81: 2964–2971.

    PubMed  CAS  Google Scholar 

  31. Taga K, Cherney B, Tosato G. Interleukin-10 inhibits apoptotic cell death in human T cell starved of IL-2. Int Immunol 1993; 5: 1599–1506.

    Article  PubMed  CAS  Google Scholar 

  32. Jinquan T, Larsen CG, Gesser B, Matsushima K, Thestrup-Pedersen K. Human IL-10 is a chemoattractant for CD8+ T lymphocytes and an inhibitor of IL-8-induced CD4+ T lymphocyte migration. J Immunol 1993; 151: 4545–4551.

    PubMed  CAS  Google Scholar 

  33. Go NF, Castle B, Barrett R, et al. IL-10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. J Exp Med 1990; 172: 1625–1631.

    Article  PubMed  CAS  Google Scholar 

  34. Levy Y, Brouet JC. IL-10 prevents the apoptotic cell death of germinal center B cells by the induction of the bcl-2 protein. J Clin Invest 1994; 93: 424–428.

    Article  PubMed  CAS  Google Scholar 

  35. Rousset F, Garcia E, Defrance T, et al. Interleukin 10 is apotent growth and differentiation factor for activated human B lymphocytes. Immunology 1992; 89: 1890.

    CAS  Google Scholar 

  36. Saeland S, Duvert V, Moreau I, et al. Human B cell precursors proliferate and express CD23 after CD40 ligation. J Exp Med 1993; 178: 113–120.

    Article  PubMed  CAS  Google Scholar 

  37. Burdin N, Peronne C, Banchereau J, Rousset F. Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10. J Exp Med 1993; 177: 295–304.

    Article  PubMed  CAS  Google Scholar 

  38. Miyazaki I, Cheung RK, Dosch HM. Viral interleukin 10 is critical for the induction of B cell growth transformation by Epstein-Barr virus. J Exp Med 1993; 178: 439–447.

    Article  PubMed  CAS  Google Scholar 

  39. Fluckiger AC, Durand I, Banchereau J. Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells. J Exp Med 1994; 179: 91–99.

    Article  PubMed  CAS  Google Scholar 

  40. Briére F, Servet Delprat C, Bridon J-M, et al. HIL-10 induces naive sIgD+ B cells to secrete IgG1 and IgG3. J Exp Med 1994; 179: 757–762.

    Article  PubMed  Google Scholar 

  41. Ghalib HW, Piuvezam MR, Skeiky, YA et al. Interleukin 10 production correlates with pathology in human Leishmania donovani infections. J Clin Invest 1993; 92: 324–329.

    Article  PubMed  CAS  Google Scholar 

  42. Holaday BJ, Pompeu MM, Jeronimo S, et al. Potential role for interleukin-10 in the immunosuppression associated with kala azar. J Clin Invest 1993; 92: 2626–2632.

    Article  PubMed  CAS  Google Scholar 

  43. Yamamura M, Uyemura K, Deans RJ, et al. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 1991; 254: 277–279.

    Article  PubMed  CAS  Google Scholar 

  44. Sieling PA, Abrams JS, Yamamura M, et al. Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. J Immunol 1993; 150: 5501–5510.

    PubMed  CAS  Google Scholar 

  45. Clerici M, Wynn TA, Berzofsky JA, et al. Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest 1994; 93: 768–775.

    Article  PubMed  CAS  Google Scholar 

  46. Bacchetta R, Bigler M, Touraine JL, et al. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med 1994; 179: 493–502.

    Article  PubMed  CAS  Google Scholar 

  47. Emilie D, Touitou R, Raphael M, et al. In vivo production of interleukin-10 by malignant cells in AIDS lymphomas. Eur J Immunol 1992; 22: 2937–2942.

    Article  PubMed  CAS  Google Scholar 

  48. Voorzanger N, Touitou R, MC Favrot, et al. Correlation between IL-10 expression and the presence of EBV in non Hodgkin’s lymphoma. Blood 1994; 84: 159a (abstract).

    Google Scholar 

  49. Pisa P, Halapi E, Pisa EK, et al. Selective expression of IL-10, IFNg and GM-CSF in ovarian cancer biopsies. Proc Natl Acad Sci USA 1992; 89: 7708–7712.

    Article  PubMed  CAS  Google Scholar 

  50. Gastl GA, Abrams JS, Nanus DM, et al. Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression. Int J Cancer 1993; 55: 96–101.

    Article  PubMed  CAS  Google Scholar 

  51. Yamamura M, Modlin RL, Ohmen JD, Moy RL. Local expression of anti-inflammatory cytokines in cancer. J Clin Invest 1993; 91: 1005–1010.

    Article  PubMed  CAS  Google Scholar 

  52. Smith DR, Kunkel SL, Burdick MD, et al. Production of interleukin-10 by human bronchogenic carcinoma. Am J Pathol 1994; 145: 18–25.

    PubMed  CAS  Google Scholar 

  53. Nitta T, Hishii M, Sato K, Okumura K. Selective expression of interleukin-10 gene within glioblastoma multiform. Brain Res 1994; 649: 122–128.

    Article  PubMed  CAS  Google Scholar 

  54. Chen Q, Daniel V, Maher DW, Hersey P. Production of IL-10 by melanoma cells: examination of its role in immunosuppression mediated by melanoma. Int J Cancer 1994; 56: 755–760.

    Article  PubMed  CAS  Google Scholar 

  55. Sato T, Takao Y, Berd J. IL-10 production in metastatic melanoma. Proc Am Assoc Cancer Res 1995; 36: 466 (abstract).

    Google Scholar 

  56. Blay JY, Burdin N, Rousset F, et al. Serum interleukin-10 in non-Hodgkin’s lymphoma: a prognostic factor. Blood 1993; 82: 2169–2174.

    PubMed  CAS  Google Scholar 

  57. Stasi R, Zinzani L, Galieni P, et al. Detection of soluble interleukin-2 receptor and interleukin-10 in the serum of patients with aggressive non-Hodgkin’s lymphoma. Identification of a subset at high risk of treatment failure. Cancer 1994; 74: 1792–1800.

    Article  PubMed  CAS  Google Scholar 

  58. Gotlieb WH, Abrams JS, Watson JM, Velu TJ, Berek JS, Martinez-Maza O. Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers. Cytokine 1992; 4: 385–390.

    Article  PubMed  CAS  Google Scholar 

  59. Merville P, Rousset F, Banchereau J, et al. Serum IL-10 in earlystage multiple myeloma. Lancet 1992; 340: 1544–1545.

    Article  PubMed  CAS  Google Scholar 

  60. Benjamin D, Knobloch TJ, Dayton MA. Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt’s lymphoma constitutively secrete large quantities of interleukin-10. Blood 1992; 80: 1289–1298.

    PubMed  CAS  Google Scholar 

  61. Stewart JP, Behm FG, Arrand JR, Rooney CM. Differential expression of viral and human interleukin-10 (IL-10) by primary B cell tumors and B cell lines. Virology 1994; 200: 724–732.

    Article  PubMed  CAS  Google Scholar 

  62. Finke J, Ternes P, Lange W, Mertelsmann R, Dolken G. Expression of interleukin 10 in B lymphocytes of different origin. Leukemia 1993; 7: 1852–1857.

    PubMed  CAS  Google Scholar 

  63. Nakagomi H, Dolcetti R, Bejarano MT, Pisa P, Kiessling R, Masucci MG. The Epstein- Barr virus latent membrane protein-1 (LMP1) induces interleukin-10 production in Burkitt lymphoma lines. Int J Cancer 1994; 57: 240–244.

    Article  PubMed  CAS  Google Scholar 

  64. Cortes JE, Talpaz M, Cabanillas F, et al. Serum levels of IL-10 in patients with diffuse large cell non Hodgkin’s lymphoma: lack of correlation with prognostic. Blood 1994; 84: 160a (abstract).

    Google Scholar 

  65. Akridge RE, Oyafuso LK, Reed SG. IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages. J Immunol 1994; 153: 5782–5789.

    PubMed  CAS  Google Scholar 

  66. Masood R, Lunardi-Iskandar Y, Moudgil T, Zhang Y, Law RE, Huang CL, Puri RK, Levine AM, Gill PS. IL-10 inhibits HIV-1 replication and is induced by tat. Biochem Biophys Res Commun 1994; 202: 374–383.

    Article  PubMed  CAS  Google Scholar 

  67. Wang L, Goillot E, Tepper RI. IL-10 inhibits alloreactive cytotoxic T lymphocyte generation in vivo Cell Immunol 1994; 159: 152.

    Article  PubMed  CAS  Google Scholar 

  68. Donawho CK, Bucana CD, Kripke ML. Enhanced growth of murine melanoma by UVB is dependent on IL-10. Proc Am Assoc Cancer Res 1995; 36: 475 (abstract).

    Google Scholar 

  69. Allione A, Consalvo M, Nanni P, et al. Immunizing and curative potential of replicating and non replicating murine mammary adenocarcinoma cells engineered with IL-2, IL-4, IL-6, IL-7, IL-10, TNFa, GM-CSF and IFNg gene or admixed with conventional adjuvants. Cancer Res 1994; 54: 6022–6026.

    PubMed  CAS  Google Scholar 

  70. Kundu N, Beaty T, Jackson MJ, Fulton AM. IL-10 inhibits mammary tumor growth and metastasis. Proc Am Assoc Cancer Res 1995; 36: 465 (abstract).

    Google Scholar 

  71. Richter G, Kruger-Krasagakes S, Hein G, et al. Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration. Cancer Res 1993; 53: 4134–4137.

    PubMed  CAS  Google Scholar 

  72. Peng B, Sherr DH, Mahboudi F, et al. A cultured malignant B-l line serves as a model for Richter’s syndrome. J Immunol 1994; 153: 1869–1880.

    PubMed  CAS  Google Scholar 

  73. Peng B, Raveche E. Regulation of malignant B-l cells by IL-10 antisense oligonucleotides. Proc Am Soc Cancer Res 1995; 36: 495 (abstract).

    Google Scholar 

  74. Masood R, Bond M, Scadden D, Kaplan M, Levine AM, Gill PS. IL-10: an autocrine B-cell growth factor for human B cell lymphoma and their progenitors. Blood 1992; 80: 115a (abstract)

    Google Scholar 

  75. Demidem A, Lam D, Gan X-H, Levine A, Sallahuddin Z, Bonavida B. Endogenous IL-10 is a protective factor in drug resistant AIDS related lymphoma. Proc Am Assoc Cancer Res 1995; 36: 323 (abstract).

    Google Scholar 

Download references

Authors
  1. N. Voorzanger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J.-Y. Blay
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hôpital Edouard Herriot, Pavillon P, 5, Place d’Arsonval, 69437, Lyon 3, France

    J. L. Touraine

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Voorzanger, N., Blay, JY. (1996). Interleukin 10 and non Hodgkin’s lymphomas. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Cancer in Transplantation: Prevention and Treatment. Transplantation and Clinical Immunology, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0175-9_26

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0175-9_26

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6563-4

  • Online ISBN: 978-94-009-0175-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation