Abstract
Ketanserin lowers arterial blood pressure in both animals and humans, but the mechanism of its antihypertensive action is in debate [see 1]. In general, it is now accepted that ketanserin, at least partly, lowers blood pressure by α 1-adrenoceptor blockade [2–4]. However, additional mechanisms, such as the blockade of 5-HT2 receptor-mediated amplification of the vasoconstrictor action of noradrenaline by 5-hydroxytryptamine (5-HT) [see 5], direct vasodilatation [4] and a CNS action [6–8], have also recently been implicated. In this investigation the effects of intrathecal administration of ketanserin and phentolamine on arterial blood pressure and heart rate in normotensive anaesthetized rats have been studied.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Saxena PR, Bolt GR, Dhasmana KM (1987): Serotonin agonists and antagonists in experimental hypertension. J Cardiovasc Pharmacol 10 (suppl. 3): S12–S18.
Fozard JR (1982): Mechanism of the hypotensive effect of ketanserin. J Cardiovasc Pharmacol 4: 829–838.
Kalkman HO, Timmermans PBMWM, Van Zwieten PA (1982): Characterization of the antihypertensive properties of ketanserin (R 41486) in rats. J Pharmacol Exp Ther 22: 227–231.
Bolt GR, Saxena PR (1985): Cardiovascular profile and hypotensive mechanism of ketanserin in the rabbit. Hypertension 7: 499–506.
Vanhoutte PM, Amery A, Birkenhäger W, Breckenridge A, Bühler F, Distler A, Dormandy J, Doyle A, Frohlich E, Hansson L, Hedner T, Hollenberg N, Jensen H-E, Lund-Johansen P, Meyer P, Opie L, Robertson I, Safar M, Schalekamp M, Symoens J, Trap-Jensen J, Zanchetti A (1988): Serotonergic mechanisms in hypertension: Focus on the effects of ketanserin. Hypertension 11: 111–133.
McCall RB, Schuette MR (1984): Evidence for an alpha-1 receptor-mediated central sympathoinhibitory action of ketanserin. J Pharmacol Exp Ther 228: 704–710.
Mylecharane EJ, Phillips CA, Markus JK, Show J (1985): Evidence for a central component to the hypotensive action of ketanserin in the dog. J Cardiovasc Pharmacol 7: 514–516.
Van Zwieten PA, Mathy MJ, Boddeke HWGM, Doods HN (1987): Central hypotensive activity of ketanserin in cats. J Cardiovasc Pharmacol 10 (suppl. 3): S54–S58.
Yaksh TL, Rudy TA (1976): Chronic catheterization of the spinal subarachnoid space. Physiol Behav 17: 1031–1036.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Dhasmana, K.M., Banerjee, A.K., Saxena, P.R. (1990). The effects of intrathecal ketanserin and phentolamine on heart rate and arterial blood pressure in the rat. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_30
Download citation
DOI: https://doi.org/10.1007/978-94-009-0479-8_30
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6701-0
Online ISBN: 978-94-009-0479-8
eBook Packages: Springer Book Archive