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Neurobehavioural and Electrophysiological Effects of Lead in Rats and Monkeys

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Lead Exposure and Child Development

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Summary

The experiments reported here deal with three different topics: (1) the search for brain structures primarily involved in lead-induced neurobehavioural dysfunction, (2) the influence of the time span between indirect maternal exposure and age at behavioural testing in the rat, and (3) the role of lead in central and peripheral visual processes in monkeys. The results indicate that there are differences in the effects of lead exposure and hippocampal lesions, that permanent post-weaning lead exposure does not add to the neurobehavioural deficit due to indirect maternal exposure, and that in monkeys parameters of the visual evoked potentials and electroretinograms are altered by lead.

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References

  • Alfano, D.P and Petit, T.L. (1981) Behavioral effects of postnatal lead exposure: possible relationship to hippocampal dysfunction. Behav. Neural Biol., 32, 319–333

    Article  PubMed  CAS  Google Scholar 

  • Alfano, D.P. and Petit, T.L. (1982) Neonatal lead exposure alters the development of hippocampal dentate granule cells. Exp. Neurol, 75, 275–288

    Article  PubMed  CAS  Google Scholar 

  • Alfano, D.P., LeBoutillier, J.C. and Petit, T.L. (1982) Hippocampal mossy fiber pathway development in normal and postnatally lead exposed rats. Exp. Neurol, 75, 308–319

    Article  PubMed  CAS  Google Scholar 

  • Alfano, D.P., Petit, T.L. and LeBoutillier, J.C. (1983) Development and plasticity of the hippocampal cholinergic system in normal and early lead exposed rats. Dev. Brain Res., 10, 117–124

    Article  CAS  Google Scholar 

  • Bushnell, P.J., and Bowman, R.E. (1979) Persistence of impaired reversal learning in young monkeys exposed to low levels of dietary lead. J. Toxicol Env. Health, 5, 1015–1023

    Article  CAS  Google Scholar 

  • Bushnell, P.J., Bowman, R.E., Allen, J.R. and Marlar, R.J. (1977) Scotopic vision deficits in young monkeys exposed to lead. Science, 196, 333–335

    Article  PubMed  CAS  Google Scholar 

  • Campbell, J., Woolley, D.E., Vijayan, V.K. and Overmann, S.R. (1982) Morphometric effects of postnatal lead exposure on hippocampal development of the 15-day-old rat. Dev. Brain Res., 3, 595–612

    Article  CAS  Google Scholar 

  • Campbell, J., Overmann, S.R., Woolley, D.E. and Vijayan, V.K. (1984) Morphometric effects of preweaning lead exposure on the hippocampal formation of adult rats. Neorotoxicology, 5, 125–148

    Google Scholar 

  • Danscher, G., Hall, E., Fredens, K., Fjerdingstad, E. and Fjerdingstad, E.J. (1975) Heavy metals in the amygdala of the rat: zinc, lead and copper. Brain Res., 94, 167–172

    Article  PubMed  CAS  Google Scholar 

  • Danscher, G., Fjerdingstad, E.J., Fjerdingstad, E. and Fredens, K. (1976) Heavy metal content in subdivisions of the rat hippocampus (zinc, lead and copper). Brain Res., 112, 442–446

    Article  PubMed  CAS  Google Scholar 

  • Feeney, D.M., Longo, J.F., Cosden, M.A., Zenick, H. and Padich, R. (1979) Detection of the effects of lead exposure by visual evoked response latency. Physiol Psychol, 7, 143–145

    CAS  Google Scholar 

  • Fjerdingstad, E.J., Danscher, G. and Fjerdingstad, E. (1974) Hippocampus: selective concentration of lead in the normal rat brain. Brain Res., 80, 350–354

    Article  PubMed  CAS  Google Scholar 

  • Fox, D.A. and Sillman, A.J. (1979) Heavy metals affect rod, but not cone, photoreceptors. Science, 206, 78–80

    Article  PubMed  CAS  Google Scholar 

  • Fox, D.A., Lewkowski, J.P. and Cooper, G.P. (1977) Acute and chronic effects of neonatal lead exposure on development of the visual evoked response in rats. Toxicol Appl. Pharmacol, 40, 449–461

    Article  PubMed  CAS  Google Scholar 

  • Gross-Selbeck, E. and Gross-Selbeck, M. (1981) Changes in operant behavior of rats exposed to lead at the accepted no-effect level. Clin. Toxicol, 18, 1247–1256

    Article  PubMed  CAS  Google Scholar 

  • Hastings, L., Cooper, G.P., Bornschein, R.L. and Michealson, I A. (1979) Behavioral deficits in adult rats following neonatal lead exposure. Neurobehav. Toxicol, 1, 227–231

    PubMed  CAS  Google Scholar 

  • Jarrard, L.E. (1983) Selective hippocampal lesions and behavior: effects of kainic acid lesions on performance of place and cue tasks. Behav. Neurosci., 97, 873–889

    Article  PubMed  CAS  Google Scholar 

  • Jarrard, L.E., Okaichi, H., Steward, O. and Goldschmidt, R.B. (1984) On the role of the hippocampal connections in the performance of place and cue tasks: comparison to damage of the hippocampus. Behav. Neurosci., 98, 946–954

    Article  PubMed  CAS  Google Scholar 

  • Levin, E.D. and Bowman, R.E. (1986) Long-term lead effects on the Hamilton search task and delayed spatial alternation in monkeys. Neurobehav. Toxicol Teratol, 8, 219–224

    PubMed  CAS  Google Scholar 

  • Lilienthal, H., Winneke, G., Brockhaus, A. and Molik, B. (1986) Pre- and postnatal lead exposure in monkeys: effects on activity and learning set formation. Neurobehav. Toxicol. Teratol, 8, 265–272

    PubMed  CAS  Google Scholar 

  • Munoz, C., Garbe, K., Lilienthal, H. and Winneke, G. (1988) Significance of hippocampal dysfunction in low level lead exposure of rats. Neurobehav. Toxicol. Teratol., 10, 245–253

    Article  CAS  Google Scholar 

  • Olton, D.S., Becker, J.T. and Handelman, G.E. (1979) Hippocampus, space and memory. Behav. Brain Sci., 2, 313–365

    Article  Google Scholar 

  • Perry, N.W., Childers, D.G., Dawson, W.H. and Stewart, H.L. (1968) Dark-adapted visual evoked response. 76th Annual Convention of the American Psycological Association, pp. 315–316

    Google Scholar 

  • Shih, T.M. and Hanin, I. (1978) Effects of chronic lead exposure on levels of acetylcholine and choline and acetylcholine turnover rate in rat brain areas in vivo. Psychopharmacology, 58, 263–269

    Article  PubMed  CAS  Google Scholar 

  • Sillman, A.J., Bolnick, D.A., Bosetti, J.B., Haynes, L.W. and Walter, A.E. (1984) The effect of lead on photoreceptor response amplitude - Influence of the light stimulus. Exp. Eye Res., 39, 183–194

    Article  PubMed  CAS  Google Scholar 

  • Spekreijse, H. and Apkarian, P. (1986) The use of a system analysis approach to electrodiagnostic (ERG and VEP) assessment.Vision Res., 26, 195–219

    Google Scholar 

  • Walsh, T.J., Miller, D.B. and Dyer, R.S. (1982) Trimethyltin, a selective limbic system neurotoxicant, impairs radial arm maze performance. Neurobehav. Toxicol. Teratol, 4, 177–183

    PubMed  CAS  Google Scholar 

  • Winneke, G. (1979) Modification of visual evoked potentials in rats after longterm blood lead elevation. Activ. Nerv. Sup., (Praha), 21, 282–284

    Google Scholar 

  • Winneke, G., Brockhaus, A. and Baltissen, R. (1977) Neurobehavioral and systemic effects of longterm blood lead-elevation in rats. Arch. Toxicol, 37, 247–263

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. H. Lilienthal
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  2. C. Munoz
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  3. G. Winneke
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  4. C. Lenaerts
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  5. R. Hennekes
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Editor information

Editors and Affiliations

  1. Department of Child Psychiatry, Institute of Child Health Hospital for Sick Children, Great Ormond Street, London, UK

    M. A. Smith

  2. Environmental Criteria and Assessment Office Office of Health and Environment Assessment US Environmental Protection Agency, Research Triangle Park, 27711, NC, USA

    L. D. Grant (Director) (Director)

  3. Environment Research Programme, Commission of the European Communities, Rue de la Loi 200, B-1049, Brussels, Belgium

    A. I. Sors (Directorate-General for Science, Research and Development) (Directorate-General for Science, Research and Development)

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© 1989 ECSC-EEC-EAEC, Brussels — Luxembourg; EPA, USA

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Lilienthal, H., Munoz, C., Winneke, G., Lenaerts, C., Hennekes, R. (1989). Neurobehavioural and Electrophysiological Effects of Lead in Rats and Monkeys. In: Smith, M.A., Grant, L.D., Sors, A.I. (eds) Lead Exposure and Child Development. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0847-5_27

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  • DOI: https://doi.org/10.1007/978-94-009-0847-5_27

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6868-0

  • Online ISBN: 978-94-009-0847-5

  • eBook Packages: Springer Book Archive

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