Abstract
A role for the mammalian hippocampus and other limbic structures in generating symptoms of schizophrenia has been frequently suggested. The hippocampus is richly connected to important areas of neocortex, including the prefrontal granular cortex, the temporal neocortex, and the parietal areas. It is said to be functionally involved in a number of nonmotor behaviors, chiefly attention and motivation, and in the integration between informational inputs and motivational orientation. The traditional association of the hippocampal structures to short-term memory and to memory-storage pathways provides the hippocampus with functional pathways for memory retrieval which, if pathologically functioning, might be a mechanism for sensory hallucinations. Psychotic symptoms do occur in humans with phencyclidine injection, a drug known to potently activate the hippocampus. And, descriptions of various sorts of hippocampal pathology have been made in schizophrenia.
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© 1990 Kluwer Academic Publishers
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Tamminga, C.A., Lyons, K., Kuo, S.K., Thaker, G.K. (1990). Hippocampal metabolic function in schizophrenia. In: Cazzullo, C.L., Sacchetti, E., Conte, G., Invernizzi, G., Vita, A. (eds) Plasticity and Morphology of the Central Nervous System. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0851-2_5
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DOI: https://doi.org/10.1007/978-94-009-0851-2_5
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