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Overview of Current Understanding of Tumor Spread

  • Chapter
Fundamental Aspects of Cancer

Part of the book series: Cancer Growth and Progression ((CAGP,volume 1))

Abstract

Progressive stages of malignant neoplastic growth can lead to cancer metastasis which is the major cause of treatment’ failure, moribidity, and death for patients with solid malignant tumors (5, 12, 33, 44, 45, 51, 56, 58, 59). Although the treatment modalities of radiotherapy, chemotherapy, and surgery effectively treat approximately 50 per cent of patients who develop malignant tumors, the majority of patients who are refractile to these therapeutic modalities succumb to the direct or indirect effect of tumor metastases or to adverse consequences associated with these therapeutic approaches (5, 33). At the time of diagnosis of primary tumors, approximately 50 per cent of patients with solid malignant tumors already host subclinical micrometastases, which may subsequently expand and contribute to direct anatomical compromise. In fact, a detected metastatic lesion in a particular organ may indicate the presence of other occult micrometastases. The heterogeneity of metastatic subpopulations and their scattered anatomic distribution may indeed limit or prevent effective surgical or chemotherapeutic intervention (5, 33).

This chapter is dedicated to the late Jørgen Fogh, M.D., who was associated for many years with the Sloan-Kettering Institute for Cancer Research, Rye, New York.

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Authors
  1. Ronald H. Goldfarb
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  2. Kenneth W. Brunson
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Editor information

Editors and Affiliations

  1. Pittsburgh Cancer Institute, 3343 Forbes Avenue, Pittsburgh, Pennsylvania, 15213, USA

    Ronald H. Goldfarb Ph.D.

  2. Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, USA

    Ronald H. Goldfarb Ph.D.

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© 1989 Kluwer Academic Publishers

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Goldfarb, R.H., Brunson, K.W. (1989). Overview of Current Understanding of Tumor Spread. In: Goldfarb, R.H. (eds) Fundamental Aspects of Cancer. Cancer Growth and Progression, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1089-8_3

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  • DOI: https://doi.org/10.1007/978-94-009-1089-8_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6980-9

  • Online ISBN: 978-94-009-1089-8

  • eBook Packages: Springer Book Archive

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