Abstract
Cancer chemotherapy is a modality in transition. In its early days, chemotherapy was viewed with skepticism by many, and its pioneers were forced to emphasize its positives in an aggressively defensive manner. In the early 1970s, chemotherapy appeared poised to possibly become a dominant modality. This was caused by the concept of adjuvant chemotherapy which appeared validated by the early relapse-free survival gains reported in the treatment of primary breast cancer. A decade later it is obvious that adjuvant chemotherapy is not a dramatic breakthrough and that the modality itself has plateaued in its ability to cure and palliate malignant disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Carter SK, Bakowski M, Hellmann K: Chemotherapy of Cancer, 2nd edition. John Wiley and Sons, NY, 1981
Carter SK, Livingston RG, Glatstein E: Principles of Cancer Treatment. McGraw-Hill, NY, 1982
De Vita VT, Hellman S, Rosenberg SA: Cancer Principles and Practice of Oncology, 2nd edition. J.B. Lippincott Co., Philadelphia, 1985
Carter SK: Some Thoughts on Resistance to Cancer Chemotherapy Cancer Treatment Reviews 11:3–7, 1984
Skipper HE, Simpson-Herren L: Relationship between Tumor Stem Cell Heterogeneity and Resistance to Chemotherapy. In: De Vita VT, Hellman S, Rosenberg SA: Important Advances in Oncology, 1985. J.B. Lippincott, Philadelphia, pp. 63–78 1985
Chabner BA, Fine RL, Allegra CJ et al: Cancer Chemotherapy Progress and Expectations, 1984. Cancer 54:2599–2608, 1984
Fidler IJ: Recent Concepts of Cancer Metastasis and Their Implications for Therapy. Cancer Treat Rep 68:193–198, 1984
McGuire WL (Moderator), Goldie JH, Salmon SE, Ling V: Strategies to Identify or Prevent Drug Resistance in Cancer — A Panel Discussion. Breast Cancer Res and Treatment 5:257–268, 1985
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Kluwer Academic Publishers, Dordrecht
About this chapter
Cite this chapter
Carter, S.K. (1989). Neoplastic Heterogeneity and Clinical Chemotherapy. In: Goldfarb, R.H. (eds) Fundamental Aspects of Cancer. Cancer Growth and Progression, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1089-8_9
Download citation
DOI: https://doi.org/10.1007/978-94-009-1089-8_9
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6980-9
Online ISBN: 978-94-009-1089-8
eBook Packages: Springer Book Archive