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Special aspects of inflammatory bowel disease in children

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Inflammatory Bowel Disease and Coeliac Disease in Children
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Abstract

The inflammatory bowel diseases, chronic non-specific ulcerative colitis and Crohn’s disease, have been increasingly recognized as important clinical entities in paediatric patients. In the following discussion, an overview of selected features of these disorders as they affect children is presented, recognizing that areas relating to genetics, endoscopic and radiological diagnosis, and management (medical, dietary and surgical) are addressed elsewhere in the Symposium.

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References

  1. Barton, J.R., Gillon, S. and Ferguson, A. (1989). Incidence of inflammatory bowel disease in Scottish children between 1968 and 1983: marginal fall in ulcerative colitis, three-fold rise in Crohn’s disease. Gut, 30, 618–622

    Article  PubMed  CAS  Google Scholar 

  2. Farmer, R.G. and Michener, W.M. (1979). Prognosis of Crohn’s disease with onset in childhood or adolescence. Dig. Dis. Sci., 24, 752–757

    Article  PubMed  CAS  Google Scholar 

  3. Michener, W.M., Whelan, G., Greenstreet, R.L. and Farmer, R.G. (1982). Comparison of the clinical features of Crohn’s disease and ulcerative colitis with onset in childhood or adolescence. Cleveland Clin. Q., 49, 13–16

    CAS  Google Scholar 

  4. Calkins, B.H. and Mendeloff, A.I. (1986). Epidemiology of inflammatory bowel disease. Epidemiol. Rev., 8, 60–91

    PubMed  CAS  Google Scholar 

  5. Gilat, T. and Langman, M.J.S. (1987). Childhood factors in ulcerative colitis and Crohn’s disease: an international cooperative study. Scand. J. Gastroenterol., 22, 1009–1024

    Article  PubMed  CAS  Google Scholar 

  6. Mayer, L. and Shlien, R. (1987). Evidence for function of la molecules on gut eipthelial cells in man. J. Exp. Med., 166, 1471–1483

    Article  PubMed  CAS  Google Scholar 

  7. Mayer, L. and Eisenhardt, D. (1987). Lack of induction of suppressor T cells by gut epithelial cells from patients with inflammatory bowel disease. The primary defect? (Abstract) Gastroenterology, 92, 1524

    Google Scholar 

  8. MacDermott, R.P. (1987). Expression of human immunoglobulin G subclasses in inflammatory bowel diseases. Gastroenterology, 93, 1127–1134

    PubMed  CAS  Google Scholar 

  9. Hirata, I., Berrivi, G., Austin, L.L., Keren, D.F. and Dobbins, W.O. III. (1986). Induction of HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease. Dig. Dis. Sci., 31, 593–603

    Article  PubMed  CAS  Google Scholar 

  10. Markowitz, J., Daum, F., Aiges, H., Kahn, E., Silverberg, M. and Fisher, S.E. (1984). Perianal disease in children and adolescents with Crohn’s disease. Gastroenterology, 86, 829–833

    PubMed  CAS  Google Scholar 

  11. Michener, W.M., Farmer, R.G. and Mortimer, E.A. (1979). Long-term prognosis of ulcerative colitis with onset in childhood and adolescence. J. Clin. Gastroenterol., 1, 301–305

    Article  PubMed  CAS  Google Scholar 

  12. Mir-Madhjessi, S.H., Michener, W.M. and Farmer, R.G. (1986). Course and prognosis of idiopathic ulcerative proctosigmoiditis in young patients. J. Pediatr. Gastroenterol. Nutr., 5, 570–575

    Article  Google Scholar 

  13. Burbige, E.J., Huang, S.S. and Bayless, T.M. (1975). Clinical manifestations of Crohn’s disease in children and adolescents. Pediatrics, 55, 866–871

    PubMed  CAS  Google Scholar 

  14. Passo, M.H., Fitzgerald, J.F. and Brandt, K.D. (1986). Arthritis associated with inflammatory bowel disease: relationship of joint disease to activity and severity of bowel lesion. Dig. Dis. Sci., 31, 492–497

    Article  PubMed  CAS  Google Scholar 

  15. Greenstein, A.J., Sachar, D.B., Pucillo, A., Vassiliades, G., Smith, H., Kreel, I., Geller, S.A., Janowitz, H.D. and Aufses, A.H. (1979). The extra-intestinal complications of Crohn’s disease and ulcerative colitis: a study of 700 patients. Medicine, 55, 401–412

    Article  Google Scholar 

  16. Kirschner, B.S. and Samowitz, W.S. (1986). Secondary amyloidosis in Crohn’s disease of childhood. J. Pediatr. Gastroenterol. Nutr., 5, 816–821

    Article  PubMed  CAS  Google Scholar 

  17. Paradis, K., Bernstein, M.L. and Adelson, J.W. (1985). Thrombosis as a complication of inflammatory bowel disease in children; a report of four cases. J. Pediatr. Gastroenterol. Nutr., 4, 659–662

    Article  PubMed  CAS  Google Scholar 

  18. Markowitz, R.L., Ment, L.R. and Gryboski, J.D. (1989). Cerebral thromboembolic disease in pediatric and adult inflammatory bowel disease: case report and review of the literature. J. Pediatr. Gastroenterol. Nutr., 8, 413–420

    Article  PubMed  CAS  Google Scholar 

  19. Kirschner, B.S., Voinchet, O. and Rosenberg, I.H. (1978). Growth retardation in inflammatory bowel disease. Gastroenterology, 75, 504–511

    PubMed  CAS  Google Scholar 

  20. Kanof, M.E., Lake, A.M. and Bayless, T.M. (1988). Decreased height velocity in children and adolescents before the diagnosis of Crohn’s disease. Gastroenterology, 95, 1523–1527

    PubMed  CAS  Google Scholar 

  21. Layden, T., Rosenberg, J., Nemchausky, B., Elson, C. and Rosenberg, I. (1976). Reversal of growth arrest in adolescents with Crohn’s disease after parenteral alimentation. Gastroenterology, 70, 1017–1026

    PubMed  CAS  Google Scholar 

  22. Kelts, D.G., Grand, R.J., Shen, G., Watkins, J.B., Werlin, S.L. and Boehme, C. (1979). Nutritional basis of growth failure in children and adolescents with Crohn’s disease. Gastroenterology, 76, 720–727

    PubMed  CAS  Google Scholar 

  23. Kirschner, B.S., Klich, J.R., Kalman, S.S., deFavaro, M.V. and Rosenberg, I.H. (1981). Reversal of growth retardation in Crohn’s disease with therapy emphasizing oral nutritional restitution. Gastroenterology, 80, 10–15

    PubMed  CAS  Google Scholar 

  24. Motil, K.J., Altschuler, S.I. and Grand, R.J. (1985). Mineral balance during nutritional supplementation in adolescents with Crohn’s disease and growth failure. J. Pediatr., 107, 473–479

    Article  PubMed  CAS  Google Scholar 

  25. Motil, K.J., Grand, R.J., Maletskos, C.J. and Young, V.R. (1982). The effect of disease, drug and diet on whole body protein metabolism in adolescents with Crohn’s disease and growth failure. J. Pediatr., 101, 345–351

    Article  PubMed  CAS  Google Scholar 

  26. Morin, C.L., Roulet, M. and Weber, A. (1980). Continuous elemental enteral alimentation in children with Crohn’s disease and growth failure. Gastroenterology, 79, 1205–1210

    PubMed  CAS  Google Scholar 

  27. O’Morain, C., Segal, A., Levi, A.J. and Valman, H.B. (1983). Elemental diet in acute Crohn’s disease. Arch. Dis. Child., 53, 44–47

    Article  Google Scholar 

  28. Belli, D.C., Seidman, E., Bouthillier, L., Weber, A.H., Roy, C.C., Pletincx, M., Beaulieu, M. and Morin, C.L. (1988). Chronic intermittent elemental diet improves growth failure in children with Crohn’s disease. Gastroenterology, 94, 603–610

    PubMed  CAS  Google Scholar 

  29. Strobel, C.T., Byrne, W.J. and Ament, M.E. (1979). Home parenteral nutrition in children with Crohn’s disease: an effective management alternative. Gastroenterology, 77, 272–279

    PubMed  CAS  Google Scholar 

  30. Kirschner, B.S., Schoeller, D.A. and Sutton, M.M. (1984). Measurement of energy expenditure (EE) in adolescents with Crohn’s disease (C.D.) using doubly-labelled water. (Abstract) Gastroenterology, 86, 1136

    Google Scholar 

  31. Gotlin, E.W. and Dubois, R.S. (1973). Nyctohemeral growth hormone levels in children with growth retardation and inflammatory bowel disease. Gut, 14, 191–195

    Article  PubMed  CAS  Google Scholar 

  32. Tenore, R.L., Berman, W.F., Parks, J.S. and Bongiovanni, A.M. (1977). Basal and stimulated growth hormone concentrations in inflammatory bowel disease. J. Clin. Endocrinol. Metab., 44, 622–628

    Article  PubMed  CAS  Google Scholar 

  33. Farthing, M.J.G., Campbell, C.A., Walker-Smith, J., Edwards, C.R.W., Rees, L.H. and Dawson, A.M. (1981). Nocturnal growth hormone and gonadotropin secretion in growth retarded children with Crohn’s disease. Gut, 22, 933–938

    Article  PubMed  CAS  Google Scholar 

  34. Kirschner, B.S. and Sutton, M.M. (1986). Somatomedin-C level in growth-impaired children and adolescents with chronic inflammatory bowel disease. Gastroenterology, 91, 830–836

    PubMed  CAS  Google Scholar 

  35. Phillips, L.S. and Young, H.S. (1976). Nutrition and somatomedin, I. Effect of fasting and refeeding on serum somatomedin activity and cartilage growth activity in rats. Endocrinology, 99, 304–314

    Article  PubMed  CAS  Google Scholar 

  36. Chong, S.K.F., Grossman, A., Walker-Smith, J.A. and Rees, L.H. (1984). Endocrine dysfunction in children with Crohn’s disease. J. Pediatr. Gastroenterol Nutr., 3, 529–534

    Article  PubMed  CAS  Google Scholar 

  37. Navarro, J., Vargas, J., Cezard, J.P., Charritat, J.L. and Polonovski, C. (1982), Prolonged constant rate elemental enteral nutrition in Crohn’s disease. J. Pediatr. Gastroenterol. Nutr., 1, 541–546

    Article  PubMed  CAS  Google Scholar 

  38. Kirschner, B.S. (1988). Enteral nutrition in inflammatory bowel disease. In Report of the 94th Ross Conference on Pediatric Research, Enteral Feeding: Scientific Basis and Clinical Applications, pp. 103–109. ( Ohio: Ross Laboratories )

    Google Scholar 

  39. Homer, D.R., Grand, R.J. and Colodny, A.H. (1977). Growth course and prognosis after surgery for Crohn’s disease. Pediatrics, 59, 717–725

    PubMed  CAS  Google Scholar 

  40. Wesson, D.E. and Schandling, B. (1981). Results of bowel resection for Crohn’s disease in the young. J. Pediatr. Surg., 16, 449–452

    Article  PubMed  CAS  Google Scholar 

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© 1990 Kluwer Academic Publishers

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Kirschner, B.S. (1990). Special aspects of inflammatory bowel disease in children. In: Hadziselimovic, F., Herzog, B., BĂĽrgin-Wolff, A. (eds) Inflammatory Bowel Disease and Coeliac Disease in Children. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1850-4_3

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  • DOI: https://doi.org/10.1007/978-94-009-1850-4_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7324-0

  • Online ISBN: 978-94-009-1850-4

  • eBook Packages: Springer Book Archive

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