Abstract
The majority of N-nitroso compounds (NNO) are mutagenic and/or carcinogenic [1]. There have been a number of direct and indirect demonstrations of the formation of nitrosamines in vivo in experimental animals and these have been reviewed by Archer [2]. Some N-nitroso compounds, such as N-nitrosoproline, are not readily metabolized and consequently appear unchanged in the urine [3]. Thus the in vivo formation of NNO in man has been demonstrated by the appearance of N-nitrosoproline in the urine after ingestion of nitrate and proline [4]. The total amount of NNO in the urine has therefore been regarded as a measure of the total in vivo formation of N-nitroso compound.
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References
National Academy of Sciences. (1981). In The Health Effects of Nitrate, Nitrite and N-Nitroso compounds, National Academy Press, Washington DC, 5.3–5. 78
Archer, M.C. (1982). Hazards of nitrate, nitrite and N-nitroso compounds in human nutrition. In Hathcock, J.N. (ed.), Nutritional Toxicology 1, Academic Press Inc., New York, 327–81
Chu, C. and Magee, P.N. (1981). Metabolic fate of nitrosoproline in the rat. Cancer Res., 41, 3653.
Ohshima, H., Bereziat, J.C. and Bartsch, H. (1982). Monitoring N-nitrosamino acids excreted in the urine and faeces of rats as an index for endogenous nitrosation. Carcinogenesis, 3, 115
Bartholomew, B. and Hill, M.J. (1984). The pharmacology of dietary nitrate and the origin of urinary nitrate. Fd. Chem. Toxic., 22, 749
Walters, C.L. and Smith, P.L.R. (1981). The effect of water-borne nitrate on salivary nitrite. Fd. Cosmet. Toxic., 19, 297–302
Stephany, R.W. and Schuller, P.L. (1980). Daily dietary intakes of nitrate, nitrite and volatile N-nitrosamines in the Netherlands using the duplicate portion sampling technique. Oncology, 37, 203
Walters, C.L., Downes, M.J., Edwards, M.W. and Smith, P.L.R. (1978). Determination of a non-volatile N-nitrosamine on a food matrix. Analyst, Lond, 103, 1127–33
Walters, C.L., Gillatt, P.N., Palmer, R.C. and Smith, P.L.R. (1986). Rapid method for the determination of nitrate and nitrite by chemiluminescence. Leatherhead Fd RA. Res. Rep. No. 547
Hart, R.J. and Walters, C.L. (1983). The formation of nitrite and N-nitroso compounds in saliva in vitro and in vivo. Fd. Chem. Toxic., 21, 749
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Smith, P.L.R., Gillatt, P.N., Walters, C.L. (1990). Early Detection of Patients at High Risk of Developing Gastric Cancer. In: Reed, P.I., Carboni, M., Johnston, B.J., Guadagni, S. (eds) New Trends in Gastric Cancer. Developments in Oncology, vol 59. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2167-2_5
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DOI: https://doi.org/10.1007/978-94-009-2167-2_5
Publisher Name: Springer, Dordrecht
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