Abstract
Transgenic mammals can be produced by microinjection of foreign DNA into pronuclei of zygotes. Fusion genes where the metallothionein I promotor has been connected co the structural gene for rat or human growth hormone has been introduced in mice by Palmiter et al. (1982, 1983). About 50 % of the animals have expressed these additional genes, most of them grew significantly larger than their littermates and enhanced growth rate was shown to be heritable.
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References
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© 1988 Martinus Nijhoff Publishers, Dordrecht
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Brem, G., Wanke, R. (1988). Phenotypic and Patho-Morphological Characteristics in a Half-Sib-Family of Transgenic Mice Carrying Foreign MT-HGH Genes. In: Beynen, A.C., Solleveld, H.A. (eds) New Developments in Biosciences: Their Implications for Laboratory Animal Science. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3281-4_18
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DOI: https://doi.org/10.1007/978-94-009-3281-4_18
Publisher Name: Springer, Dordrecht
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