Abstract
Coronary occlusion causes a sudden cessation of blood flow in the areas distal to the occlusion site starting a dynamic process of bio-electrical, biochemical, (ultra)structural and contractile changes. During this evolutionary process, progressing in a “wave-front”-1ike manner (Reimer et al., 1977) from endo-to epicardium initially reversible phases of ischemic injury lead to the final stage of completed infarction so that cellular viability is irreversibly lost.
Operated for the US Department of Energy by the University of California under contract no. DE-AC03-76-SF00012. This work was supported in part by the Director of the Office of Energy Research, Office of Health and Environmental Research, by NIH grant nos. HL 29845 and HL 33177, and by an Investigatorship Group Award by the Greater Los Angeles Affiliate of the American Heart Association.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bergmann, S.R., Lerch, R.A., Fox, K.A. et al. 1982. Temporal dependence of beneficial effects of coronary thrombolysis characterized by positron tomography. Am. J. Med., 73, 573–581.
Braunwald, E., Kloner, R.A. 1982. The stunned myocardium: prolonged, post-ischemic ventricular dysfunction. Circulation, 66, 1146–1149.
Brunken, R., Tillisch, J., Schwaiger, M. et al. 1986. Regional perfusion, glucose metabolism, and wall motion in patients with chronic electrocardiographic Q-wave infarctions: evidence for persistence of viable tissue in some infarct regions by positron emission tomography. Circulation, 73, 951–963.
Lee, J.T., Toleker, R.E., Reimer, K.A. 1981. Myocardial infarct size and location in relation to the coronary vascular bed at risk in man. Circulation, 64, 526–534.
Liedtke, A.J.. 1981. Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog. Cardiovasc. Dis., 23, 321–336.
Marshall, R.C., Tillisch, J.H., Phelps, M.E. et al. 1983. Identification and differentiation of resting myocardial ischemia and infarction in man with positron computed tomography, F18 labeled fluorodeoxyglucose and N13-ammonia. Circulation, 67, 766–777.
Reimer, K.A., Lowe, J.E., Rasmussen, M.M. et al. 1977. The wavefront phenomenon of ischemic cell death. I. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation, 56, 786–794.
Santiago, C., Castaner, A., Gines, S. et al. 1983. Prevalence and prognosis after a first non-transmural myocardial infarction. Am. J. Cardiol., 51, 1584.
Schelbert, H.R. 1956. Evaluation of “metabolic fingerprints” of myocardial ischemia. Can. J. Cardiol., 7, 121A-130A.
Schelbert, H.R., Phelps, M.E., Shine, K.I. 1983. Imaging metabolism and biochemistry - a new look at the heart. Am. Heart, 105, 522–526.
Schwaiger, M., Brunken, R., Grover-May, M. et al. 1986. Regional myocardial metabolism in patients with acute myocardial infarction assessed by positron emission tomography. J. Am. Coll. Cardiol., 8, 800–808.
Schwaiger, M., Hansen, H.W., Sochor, H. et al. 1984. Delayed recovery of regional glucose metabolism in reperfused canine myocardium by positron-CT. J. Am. Coll. Cardiol., 3, 552.
Schwaiger, M., Schelbert, H.R., Ellison, D. et al. 1985. Sustained regional abnormalities in cardiac metabolism after transient ischemia in the chronic dog model. J. Am. Coll. Cardiol., 6, 336–347.
Sniderman, A.D., Beaudry, J.P., Rahal, D.P. 1983. Early recognition of the patient at late high risk: incomplete infarction and vulnerable myocardium. Am. J. Cardiol., 52, 669–673.
Sochor, H., Schwaiger, M., Schelbert, H.R. et al. 1985. Assessment of tissue viability in reperfused canine myocardium by a multiple radiotracer technique. J. Am. Coll. Cardiol., 5, 451.
Tillisch, J., Brunken, R., Marshall, R. et al. 1986. Prediction of the reversibility of cardiac wall motion abnormalities using positron tomography, 18fluorodeoxyglucose and 13N-ammonia. N. Engl. J. Med., 314, 884–888.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 ECSC, EEC, EAEC, Brussels-Luxembourg
About this chapter
Cite this chapter
Sochor, H., Schwaiger, M., Brunken, R. (1987). PET in the Evaluation of Myocardial Infarction. In: Heiss, WD., Pawlik, G., Herholz, K., Wienhard, K. (eds) Clinical efficacy of positron emission tomography. Developments in Nuclear Medicine, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3345-3_29
Download citation
DOI: https://doi.org/10.1007/978-94-009-3345-3_29
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8002-6
Online ISBN: 978-94-009-3345-3
eBook Packages: Springer Book Archive