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Stability and change through DNA repair

  • Chapter
Accuracy in Molecular Processes

Abstract

DNA is continually threatened by physical, chemical and biological factors which alter its structure, and so modify or block its biological activity. The role of DNA repair is to counter these changes. In conferring resistance to DNA damage, some repair systems simply remove DNA lesions, so regenerating the original DNA sequence. In other instances, lesions are not removed. Their effects are tolerated, or avoided, by recombination or changes in DNA replication, so that there is an intrinsic possibility of genetic rearrangement or sequence change as a result of repair. Thus, DNA repair mechanisms can be seen both as a means of maintaining DNA sequence and, on other occasions, as a source of variability or rearrangement.

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    T. B. L. Kirkwood  & R. F. Rosenberger  & 

  2. University of Southern California, Los Angeles, USA

    D. J. Galas

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Sedgwick, S.G. (1986). Stability and change through DNA repair. In: Kirkwood, T.B.L., Rosenberger, R.F., Galas, D.J. (eds) Accuracy in Molecular Processes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4097-0_9

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