Abstract
Mallory bodies (MBs) are characteristic hepatocellular cytoplasmic inclusions, predominantly, but not exclusively associated with alcoholic hepatitis (see references 1, 2 for review). This disease is the link between the reversible fatty liver and the irreversible liver cirrhosis of the alcoholic. The pathogenesis of alcoholic hepatitis is still unresolved. Studies on structure and mechanisms of MB formation may, however, provide not only further information on cellular alterations specifically associated with alcohol intoxication but also on basic mechanisms of liver cell injury. Studies on the development of MBs are facilitated by the existence of an animal model, the griseofulvin-treated mouse, in which MBs can be produced under standardized conditions3. The data presented in the following communication were mainly obtained using this model.
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References
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Denk, H., Hazan, R., Lackinger, E., Schiller, D.L., Franke, W.W. (1985). Studies on the development of Mallory bodies. In: Bianchi, L., Gerok, W., Popper, H. (eds) Trends in Hepatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4904-1_19
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DOI: https://doi.org/10.1007/978-94-009-4904-1_19
Publisher Name: Springer, Dordrecht
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