Abstract
In order to elucidate the processes by which cells take up specific molecules it has to be established whether uptake occurs by simple diffusion or by some form of facilitated transport1. In the latter case, determination of the driving forces and of the specific membrane transport machinery at the molecular level is also essential. Bile acids2,3, non-bile acid cholephils such as sulphobromophthalein (BSP) and bilirubin4-6, and free fatty acids7 represent three classes of organic anions, the hepatocellular uptake of which has been extensively studied. In recent years it has become apparent that these three classes, which differ widely in both their physicochemical properties and their metabolic roles, nevertheless share a number of similarities with respect to their hepatocellular uptake8.
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Berk, P.D. et al. (1985). Progress in understanding the mechanisms of organic anion uptake by the liver. In: Bianchi, L., Gerok, W., Popper, H. (eds) Trends in Hepatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4904-1_3
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DOI: https://doi.org/10.1007/978-94-009-4904-1_3
Publisher Name: Springer, Dordrecht
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