Abstract
Although an iron overload in human pathology may be associated with osteoporosis, it cannot be inferred that iron plays a role in bone changes. Osteoporosis in primary hemochromatosis may be related to multi-endocrine deficiency (De60, Ro79) and in Bantu hemochromatosis to vitamin C deficiency (Wa71). Furthermore, in both cases, hepatic failure frequently associated with bone loss, may also induce osteoporosis (Lo78). In thalassemia major with secondary hemochromatosis, impaired bone mineralization and apposition associated with iron bone overload have been observed (Ve82). The role of iron in such disorders, however, has not been demonstrated. At the present time, an iron overload is also frequently observed in hemodialized patients (Go79) and; it is relevant to know whether an iron overload may play a role in renal osteodystrophy. We have therefore induced an iron overload in pigs of the same magnitude as that observed during human hemochromatosis. Bone remodelling after a 36-day iron overload was studied in growing pigs after a double tetracycline labelling (Fr69) in order to determine whether this treatment leads to bone changes.
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References
Baron R., Vignery A., Tran V.P., 1981, “The significance of lacunar erosion without osteoclasts: studies on the reversal phase of the remodeling sequence”, Bone Histomorphometry: Jef, W.S. and Parfitt A.M. ( Armour Montagu. Paris ), 35–41.
Baron R., Vignery A., Lang R., 1981, “Reversal phase and osteopenia:Defective coupling of resorption to formation in the pathogenesis of osteoporosis”, Osteoporosis: De Luca H.F. et al. (University Park Baltimore) 311–320.
Brezis M., Shalev O., Leibel B., Bernheim J., Ben Isahy D., 1980, “Phosphorus retention and hypoparathyroidism associated with transfusional iron overload in thalassemia”, Mineral Electrolyte Metab. 4, 57–62.
Brink B., Disler P., Lynch S., 1977, “Patterns of iron storage in dietary iron overload and idiopathic hemochromatosis”, J. Lab. Clin. Med. 88, 725–731.
Brissot P., Bourel M., Herry D., Verger J.P., Messner M., Beaumont C., Regnouard F., Ferrand B., Simon M., 1981, “Assessment of liver iron content in 271 patients, reevaluation of direct and indirect methods”, Gastroenterology, 80, 557–565.
Canale V.C., 1974, “Betha thalassemia, a clinical review”, Pediatr. Ann., 3, 6.
Cooperberg A.A., Rosenberg A., Schwartz J.P., 1977, “Diagnosis value of bone marrow iron deposits in idiopathic hemochromatosis”, Arch. Int. Med., 137, 748–751.
Darby A.J. and Meunier P.J., 1981, “Mean wall thickness and formation periods of trabecular bone packets in osteoporosis”, Calcif. Tissue Int., 33, 199–204.
Delbarre F., 1960, “L’ostéoporose de l’hémochromatose”, Sem. hop. Paris, 36, 3279–3284.
Frost H.M., 1969, “Tetracycline-based histological analysis of bone remodeling”, Calc. Tiss. Res., 3, 211–227.
Gokal R., Millard P.R., Weatherhall D.J., Callender S.T., Leoingham J.G., Oliver D.A., 1979, “Iron metabolism in hemodialysis patients”, Q. J. Med., 191, 369.
Jee W.S. and Nolan P.D., 1963, “Origin of oste oclasts from the fusion of phagocytes”, Nature, 200, 225–226.
Lisboa P.E., “Experimental hepatic cirrhosis in dogs caused by chronic massive iron overload”, Gut., 12, 363–368.
Long R.G., Meinhard E., Skinner R.K., Varghese Z., Wills M.R., Sherlock S., 1978, “Clinical biochemical and histological studies of osteomalacia osteoporosis and parathyroid function in chronic liver disease”, Gut., 19, 85–90.
Meunier P.J., Edouard C., Richard D.D., Laurent J., 1977, “Histomorphometry of osteoid tissue: The hyperosteoidoses”, Bone histomorphometry: P.J. Meunier ( Armour Montagu. Paris ), 249–263.
Parfitt A.M., 1982, “The coupling of bone formation to bone resorption a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis”, Metab. Bone Dis.Rel.Res., 4, 1–6.
Parfitt A.M., Villanueva A.K., Mathews C.H., Aswani J.A.,1981, “Kinetics of matrix and mineral apposition in osteoporosis and renal osteodystrophy, relationship to rate of turnover and to cell morphology”, Bone Histomorphometry: Jee W.S., Parfitt A.M. (Armour Montagu. Paris), 213–219.
Pawlotsky Y., Simon M., Hany Y., Brissot P., Bourel M., 1975, “High plasma parathyroid hormone levels and osteoarticular changes in primary hemochromatosis”, Scand. J. Rhum. supp. 4, 15–19.
Pointillart A., Fontaine N., Thomasset M., 1984, “Phytate phosphorus utilization and intestinal phosphatases in pigs fed low phosphorus: wheat or corn diets”, Nut. Rep. Int., 29, 473–483.
Powell L.W., 1970, “Changing concepts in hemochromatosis”, Post grad. Med. J., 47, 200–209.
Preece M.A., Tomlison S., Ribot C.A., Pietrek J., Korn H.T., Davies D.M., Ford J.A., Dunningham M.G., O’Riordan J.L., 1975, “Studies of vitamin D deficiency in man”, Q. J. Med., 176, 575.
Richter G.W. and Bejsis M.C., 1965, “Commentary on hemosiderin” Blood, 25, 370–373.
Roe J.H. and Kuether C.A., 1943, “The determination of ascorbic acid in whole blood an urine through the 2–4 dinitrophenylhydralarzine”, J. Biol. Chem., 339–407.
Roudier G., Hany Y., Louboutin J.Y., Ferrand B., Bourel M., 1979, “Histomorphometrie et manifestations articulaires de 1’hémochromatose idiopathique”, Rev. Rhum., 46, 91–99.
Shepard R.M. and De Luca H.F., 1980, “Determination of vitamine D and its metabolites in plasma”, Methods in enzymology ( New York, Academic Press ), 393–414.
Snedecor G.W. and Cochran W.G., 1971, “Méthodes statistiques” ( Acts, Paris ), 302–315.
Ullrey D.R., Miller E.R., Brent B.E., Bradley B.L., Hoeffer J.A., 1967, “Swine hematology from birth to maturity”, J. Anim. Sci., 26, 1024–1029.
Valberg L.S., Simon J.B., Manley P.N., 1975, “Distribution of storage iron as body iron stores expand in patients with hemochromatosis”, J. Lab. Clin. Med., 86, 479–489.
Vernejoul M.C. de, Girot R., Gueris J., Cancela L., Bang S., Bielakoff J., Mautalen C., Goldberg D., Miravet L., 1982, “Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia”, J. Clin. Endocrinol. metab., 54, 276–281.
Wapnick A.A., Lynch S.R., Seftel H.C., Charlton R.W., Bothwel T.H., Jowsey J., 1971, “The effect of siderosis and ascorbic acid depletion on bone metabolism with special reference to osteoporosis in Bantu”, Br. J. Nutr., 25, 367–370.
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© 1985 ECSC, EEC, EAEC, Brussels and Luxembourg
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de Vernejoul, M.C. et al. (1985). Effects of Iron Overload on Bone Remodelling in Pigs. In: Priest, N.D. (eds) Metals in Bone. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4920-1_30
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DOI: https://doi.org/10.1007/978-94-009-4920-1_30
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8680-6
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