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Omeprazole: A review of its pharmacological and clinical properties

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Peptic Ulcer Disease: Basic and Clinical Aspects

Part of the book series: Developments in Gastroenterology ((DIGA,volume 7))

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Abstract

Before the discovery of the histamine H2-receptor antagonists the classical anticholinergics were the only inhibitors of gastric acid secretion available. Their clinical use, however, was limited by unwanted effects and the results of treatment disappointing. This picture changed completely in the seventies with the advent of the histamine H2-receptor antagonist, cimetidine. An overwhelming number of studies showed that suppression of gastric acid secretion is indeed the mainstay in the treatment of acid peptic diseases. However safe these compounds proved to be, H2-receptors are not limited to the parietal cell and neither are the effects of the antagonists. Anticholinergics and histamine H2-receptor antagonists act systemically by blocking their specific receptors throughout the body.

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Author information

Authors and Affiliations

  1. Department of Gastroenterology, Free University Hospital, 1117, De Boelelaan, Amsterdam, 1081 HV, The Netherlands

    H. P. M. Festen, H. A. R. E. Tuynman & S. G. M. Meuwissen

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  1. H. P. M. Festen
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  2. H. A. R. E. Tuynman
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  3. S. G. M. Meuwissen
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Sophia Ziekenhuis, Zwolle, 8000 GK, The Netherlands

    G. F. Nelis MD (Consultant Physician) (Consultant Physician)

  2. Department of Surgery, Sophia Ziekenhuis, Zwolle, 8000 GK, The Netherlands

    J. Boevé M.D. (Consultant Surgeon) (Consultant Surgeon)

  3. Department of Gastroenterology & Nutrition, Central Middlesex Hospital, London, NW10 7NS, UK

    J. J. Misiewics B.Sc, M.B., F.R.C.P. (Consultant Physician and Head of the Department) (Consultant Physician and Head of the Department)

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© 1985 Martinus Nijhoff Publishers, Dordrecht

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Festen, H.P.M., Tuynman, H.A.R.E., Meuwissen, S.G.M. (1985). Omeprazole: A review of its pharmacological and clinical properties. In: Nelis, G.F., Boevé, J., Misiewics, J.J. (eds) Peptic Ulcer Disease: Basic and Clinical Aspects. Developments in Gastroenterology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5034-4_10

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  • DOI: https://doi.org/10.1007/978-94-009-5034-4_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8730-8

  • Online ISBN: 978-94-009-5034-4

  • eBook Packages: Springer Book Archive

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