Abstract
Before the discovery of the histamine H2-receptor antagonists the classical anticholinergics were the only inhibitors of gastric acid secretion available. Their clinical use, however, was limited by unwanted effects and the results of treatment disappointing. This picture changed completely in the seventies with the advent of the histamine H2-receptor antagonist, cimetidine. An overwhelming number of studies showed that suppression of gastric acid secretion is indeed the mainstay in the treatment of acid peptic diseases. However safe these compounds proved to be, H2-receptors are not limited to the parietal cell and neither are the effects of the antagonists. Anticholinergics and histamine H2-receptor antagonists act systemically by blocking their specific receptors throughout the body.
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References
Fellenius E, Berglindh T, Sachs G, et al. Substituted benzimidazoles inhibit gastric acid secretion by blocking H + -K+ ATP-ase. Nature 1981; 290: 159–161.
Sjöstrand SE, Ryberg B, Olbe L. Stimulation and inhibition of acid secretion in the isolated guinea pig gastric mucosa. Acta Physiol Scand 1978; spec. suppl.:181–5.
Wallmark B, Jaresten BM, Larsson H, Ryberg B, Brandstrom A, Fellenius E. Differentiation among inhibitory actions of omeprazole, cimetidine, and SCN” on gastric acid secretion. Am J Physiol 1983; 245: G64–71.
Fryklund J, Wallmark B, Larsson H, Helander HF. Effect of omeprazole on gastric secretion in H + -K+ ATP-ase and in pepsinogen-rich cell fractions from rabbit gastric mucosa. Biochem Pharmacol 1984; 33: 273–80.
Helander HF, Ramsay CH. Localization of omeprazole in the mouse. Gastroenterology 1984; 86 (2): 1109.
Londong W, Londong V, Cederberg C, Steffen H. Dose-response study of omeprazole on meal-stimulated gastric acid secretion and gastrin release. Gastroenterology 1983; 85: 1373–8.
Lind T, Cederberg C, Ekenved G, Haglund U, Olbe L. Effect of omeprazole - a gastric proton pump inhibitor — on pentagastrin stimulated acid secretion in man. Gut 1983; 24: 270–6.
Prichard PJ, Yeomans ND, Mihaly GW, et al. Omeprazole: A study of its inhibition of gastric pH and oral pharmacokinetics after morning or evening dosage. Gastroenterology 1985; 88: 64–9.
Howden CW, Meredith PA, Forrest JAH, Reid JL. Oral pharmacokinetics of omeprazole. Eur J Clin Pharmacol 1984; 26: 641–3.
Sharma BK, Walt RP, Pounder RE, Gomes M de FA, Wood EC, Logan LH. Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity. Gut 1984; 25: 957–64.
Carlsson E, Karlsson A, Larsson H, Lofberg I, Sundell G, SkSnberg I. Concentration of omeprazole in blood and gastric mucosa and the relation to inhibition of gastric acid secretion. Gastroenterology 1984; 86 (2): 1041.
Müller P, Dammann HG, Seitz H, Simon B. Effect of repeated, once daily, oral omeprazole on gastric secretion. Lancet 1983; 1: 66.
Stenderup J, Mertz A, Wandall JH, Bonnevie O. The inhibition of gastric- acid secretion by omeprazole in daily doses of 10 and 20 mg. Scand J Gastroenterol 1984; 19 (suppl 98): 48.
Prichard PJ, Yeomans ND, Jones DB, McNeil JJ, Louis WJ, Smallwood RA. Effect of morning or evening dosage with 10 mg omeprazole on 24 H gastric pH in duodenal ulcer patients in remission. Gastroenterology 1984; 86 (2): 1213.
Cederberg C, Lind T, Axelson M, Olbe L. Long term acid inhibitory effect of different daily doses of omeprazole 24 hours after dosing. Gastroenterology 1984; 86 (2): 1043.
Cooperative study. Omeprazole in duodenal ulceration: Acid inhibition, symptom relief, endoscopic healing, and recurrence. Br Med J 1984; 289: 525–8.
Festen HPM, Tuynman HARE, Defize J, Frants RR, Straub JP, Meuwissen SGM. The effect of single and repeated doses of oral omeprazole on gastric acid and pepsin secretion and fasting serum gastrin and serum pepsinogen I levels. Gastroenterology.
Uusitalo A, Keyrilainen O, Salaspuro M, Tarpila S. Effect of omeprazole on duodenal ulcer healing and acid secretion. XII International Congress of Gastroenterology Lisbon, Portugal 1984; abstract 31.
Scandinavian multicenter study. Gastric acid secretion and duodenal ulcer healing during treatment with omeprazole. Scand J Gastroenterol 1984; 19: 882–4.
Konturek SJ, Kweicien N, Obtulowicz W, Kopp B, Olesky J. Action of omeprazole (a benzimidazole derivate) on secretory responses to sham feeding and pentagastrin and upon serum gastrin and pancreatic polypeptide in duodenal ulcer patients. Gut 1984; 25: 14–8.
Walt RP, Gomes M de FA, Wood EC, Logan LH, Pounder RE. Effect of daily oral omeprazole on 24 hour intragastric acidity. Br Med J 1983; 287: 12–4.
Naesdal J, Bodeman G, Walan A. Effect of omeprazole, a substituted benzimidazole, on 24-H intragastric acidity in patients with peptic ulcer disease. Scand J Gastroenterol 1984; 19: 916–22.
Walt RP, Reynolds JR, Langman MJS, et al. Intravenous omeprazole rapidly raises intragastric pH. Gut 1984; 25: 1139–40.
Lind T, Moore M, Olbe L. Intravenous omeprazole: Effect on 24-hour intragastric pH. XII International Congress of Gastroenterology Lisbon, Portugal 1984, abstract 651.
Kittang E, Aadland E, Schjønsby H. Effect of omeprazole on cicid, pepsin and intrinsic factor (IF) secretion in healthy subjects. Scand J Gastroenterol 1984; 19 (suppl 98): 2.
Wilson Ja, Boyd EJS, Wormsley KG. Effect of intraduodenal omeprazole on gastric acid and pepsin secretion. Gut 1983; 24: A497–8.
Allen JM, Adrian TE, Webster J, Howe A, Bloom SR. Effect of single dose of omeprazole on the gastrointestinal peptide response to food. Hepato- Gastroenterol 1984; 31: 44–6.
Festen HPM, Thijs JC, Lamers CBHW, et al. Effect of oral omeprazole on serum gastrin and serum pepsinogen I levels. Gastroenterology 1984; 87: 1030–4.
Sharma BK, Lundborg P, Pounder RE, et al. Acid secretory capacity after treatment with omeprazole. Gastroenterology 1984; 86 (2): 1246.
Mattsson H, Anderson K, Larsson H. Omeprazole provides protection against experimentally induced gastrin mucosal lesions. Eur J Pharmacol 1983; 91: 111–4.
Kollberg B, Isenberg JI, Johansson C. Cytoprotective effect of omeprazole on the rat gastric mucosa. In: Allen A, et al (Eds). Mechanisms of mucosal protection in the upper gastrointestinal tract. Raven Press, New York 1984: 351–5.
Gustavsson S, Adami HO, Loof L, Nyberg A, Nyren O. Rapid healing of duodenal ulcers with omeprazole: double-blind dose-comparative trial. Lancet 1983; 2: 124–5.
Walan A, Bergsaker-Aspoy J, Farup P, et al. Four week study of the rate of duodenal ulcer healing with omeprazole. Gut 1983; 24: A972.
Prichard PJ, Rubinstein D, Jones DB, et al. Omeprazole: Double-blind comparison of 10 mg versus 30 mg for healing duodenal ulcers. Gastroenterology 1984; 86 (2): 1213.
Dammann HG, Classen M, Domschke W, et al. Omeprazole is superior to ranitidine within two weeks’ treatment of duodenal ulcer. XII International Congress of Gastroenterology Lisbon, Portugal 1984, abstract 1274.
Vezzadini P, Rinetti M, Tomassetti P, et al. Healing of duodenal ulcer with omeprazole. XII International Congress of Gastroenterology Lisbon, Portugal 1984, abstract 431.
Londong W, Classen M, Dammann HG, et al. Omeprazole versus ranitidine for gastric ulcer - results of a german multicenter trial. XII International Congress of Gastroenterology Lisbon, Portugal 1984, abstract 1299.
Hiitteman W. Kurzzeitbehandlung des Ulcus ventriculi mit Omeprazol in ein- mal taglicher dosierung. Dtsch med Wschr 1985; 110: 38–9.
Lamers CBHW, Lind T, Moberg S, Jansen JBMJ, Olbe L. Omeprazole in Zollinger-Ellison syndrome. Effects of a single dose and of long-term treatment in patients resistant to histamine H2-receptor antagonists. New Engl J Med 1984; 310: 758–61.
McArthur KE, Collen MJ, Cherner JA, et al. Omeprazole as a single daily dose is effective therapy in Zollinger-Ellison syndrome. Gastroenterology 1984; 86 (2): 1178.
Dent J, Heddle R, DowntonJ, Mackinnon M, ToouliJ, Lewis I. Omeprazole heals ulcerative peptic oesophagitis. Gastroenterology 1984; 86 (2): 1062.
Sharma BK, Santana IA, Walt RP, Pounder RE. Omeprazole and liver function tests. Lancet 1983; 2: 346.
Loof L, Adami HO, Gustavsson S, Nyberg A, Nyren O, Lundborg P. Omeprazole: no evidence for frequent hepatic reactions. Lancet 1984; 1: 1347–8.
Sharma BK, Santana IA, Wood EC, et al. Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole. Br Med J 1984; 289: 717–9.
Gugler R, Jensen JC. Omeprazole inhibits elimination of diazepam. Lancet 1984; 1: 969.
Henry DA, Somerville KW, Kitchingman G, Langman JS. Omeprazole: Effects on oxidative drug metabolism. Br J Clin Pharmacol 1984; 18: 195–200.
Webster LK, Jones DB, Mihaly GW, Smallwood RA. Effect of omeprazole in polyethylene glycol-400 on antipyrine elimination by the isolated perfused rat liver. J Pharm Pharmacol 1984; 36: 470–2.
Henry DA, Gerkens JF, Brent P, Somerville K. Inhibition of drug metabolism by omeprazole. Lancet 1984; 2: 46.
Horowitz M, Hetzel DJ, Buckle PJ, Chatterton BE, Shearman DJC. The effect of omeprazole on gastric emptying in patients with duodenal ulcer disease. Br J Clin Pharmacol 1984; 18: 791–4.
Howden CW, Reid JL. Omeprazole, a gastric ’proton pump inhibitor’: Lack of effect on renal handling of electrolytes and urinary acidification. Eur J Clin Pharmacol 1984; 26: 639–40.
Alumets J, El Munshid HA, H£kanson R, et al. Effect of antrum exclusion on endocrine cells of rat stomach. J Physiol 1979; 286: 145–55.
Wilander E. Achylia and the development of gastric carcinoids. Virchows Arch (pathol Anat) 1981; 394: 151–60.
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© 1985 Martinus Nijhoff Publishers, Dordrecht
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Festen, H.P.M., Tuynman, H.A.R.E., Meuwissen, S.G.M. (1985). Omeprazole: A review of its pharmacological and clinical properties. In: Nelis, G.F., Boevé, J., Misiewics, J.J. (eds) Peptic Ulcer Disease: Basic and Clinical Aspects. Developments in Gastroenterology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5034-4_10
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DOI: https://doi.org/10.1007/978-94-009-5034-4_10
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