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Evaluation of Models to Determine Platelet Life Span and Survival Curve Shape

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Blood cells in nuclear medicine, part I

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 6))

Abstract

The value of radionuclide platelet survival studies to delineate the mechanisms of thrombocytopenia and factors contributing to it has been proven (1), and the effect of various diseases and therapies on platelet survival may be evaluated by the same technique. The recent introduction of 111In-oxine as a cellular label allowing in vivo imaging of platelet distribution, has renewed interest in platelet kinetic studies (2,3).

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References

  1. Davey MG, In: The survival and destruction of human platelets. Karger S (ed), Basel, pp 85–117, 1966.

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  2. Thakur ML, Welch MJ, Joist H, Coleman RE, Indium-111-labelled platelets: Studies on preparation and evaluation of in vitro and in vivo functions. Throat. Res. 9: 345, 1976.

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  3. Heyns duP A, Lötter MG, Badenhorst PU, Van Reenen OR, Pieters H, Minnaar PC, Retief FP, Kinetics, distribution and sites of destruction of Indium-111-labelled human platelets. Brit. J. Haemat. 44: 269, 1980.

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  4. The panel on diagnostic application of radioisotopes in hematology, International Committee for standardization in Hematology: Recommended methods for radioisotope platelet survival studies. Blood 50: 1137, 1977.

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  5. Simon TL, Heyers TM, Gasron JP, Harker LH, Heparin pharmacokinetics: Increased requirements in pulmonary embolism. Brit. J. Haemat. 39: 111, 1978.

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Authors
  1. M. G. Lötter
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  2. C. P. Herbst
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  3. P. N. Badenhorst
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  4. A. duP Heyns
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  5. P. Wessels
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  6. P. C. Minnaar
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Max R. Hardeman PhD

  2. Department of Nuclear Medicine, HĂ´pital Saint Louis, Paris, France

    Yves Najean MD

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© 1984 Martinus Nijhoff Publishers, The Hague

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Lötter, M.G., Herbst, C.P., Badenhorst, P.N., duP Heyns, A., Wessels, P., Minnaar, P.C. (1984). Evaluation of Models to Determine Platelet Life Span and Survival Curve Shape. In: Hardeman, M.R., Najean, Y. (eds) Blood cells in nuclear medicine, part I. Developments in Nuclear Medicine, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6027-5_11

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  • DOI: https://doi.org/10.1007/978-94-009-6027-5_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6029-9

  • Online ISBN: 978-94-009-6027-5

  • eBook Packages: Springer Book Archive

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