Abstract
111-In-tropolonate is the latest in a series of lipid-soluble metal chelating agents used to label blood cells for clinical and biological use. The series began in 1976 with 111-In-oxinate (1) and has now been extended to include 111-In-acetylacetonate (2,3) and 111-In-oxine-sulphate (4). 111-In-chelates are now widely used as tracers for platelets and granulocytes; labelled granulocytes have proved especially valuable in the non-invasive diagnosis of abscesses and other inflammatory lesions (5,6,7) and labelled platelets for locating vascular thrombi (8) and monitoring of human kidney transplants (9).
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References
McAfee J.G. and M.L. Thakur: Survey of radioactive agents for in vitro labelling of phagocytic leucocytes. 1. Soluble Agents, J. Nucl. Med. 17:480–487, 1976.
Sinn H., and D.J. Silvester: Simplified cell labelling with 111-Indium acetylacetone. Brit. J. Radiol. 52:758–759, 1979.
Danpure H.J. and S. Osman: Cell labelling and cell damage with 111-Indium acetylacetone - an alternative to111-Indium oxine. Brit. J. Radiol., 54:597–601, 1981.
McAfee J.G., G.M Gagne, G. Subramanian, Z.D. Grossmann, F.D. Thomas, M.L. Roskopf, P. Fernandes and B.J. Lyons: Distribution of leucocytes labelled with 111-In-oxine in dogs with acute inflammatory lesions. J. Nucl. Med. 21:1059–1068, 1980.
Thakur M.L., J.P. Lavender, R.N. Arnot, D.J. Silvester and A.W. Segal: 111-Indium labelled autologous leukocytes in man. J. Nucl. Med. 18:1014–1021, 1979.
Ascher N.L., L. Forstrom and R.L. Simmons: Radiolabelled autologous leucocyte scanning in abscess detection. World J. Surgery 4:395–402, 1980.
Saverymuttu S.H., A.M. Peters, H.J. Hodgson, V.S. Chadwick and J.P. Lavender: 111-Indium autologous leucocyte scanning: comparison with radiology for imaging the colon in inflammatory bowel disease. British Medical Journal, 285:255–257, 1982.
Goodwin D.A., J.T. Bushberg, P.W. Doherty, M.J. Lipton, F.K. Conley, C.I. Diamanti and C.F. Meares:111-Indium labelled autologous platelets for location of vascular thrombi in humans. J. Nucl. Med. 19:626–634, 1978.
Fenech A., A. Nicholls and F.W. Smith: 111-In-labelled platelets in the diagnosis of renal transplant rejection: preliminary findings. Brit. J. Radiol. 54:325–327, 1981.
Thakur M.L., L. Walsh, H.L. Malech and A. Gottschalk: 111-Indium-labelled human platelets: improved method, efficacy and evaluation. J. Nucl. Med. 22:381–385, 1981.
Peters A.M., S.H. Saverymuttu, H.J. Danpure, S. Osman, J.P. Lavender, V.S. Chadwick and H.J. Hodgson: Granulocyte (PMN) kinetics: isolation and labelling in plasma abolishes lung sequestration. Clin. Sci. 62:P.69 (Abstract), 1982.
Cook J.W., A.R. Gibb, R.A. Raphael and A.R. Somerville: Tropolone Part I. The preparation and general characteristics of tropolone. J. Chem. Soc., 503–511, 1951.
Grady R.W., J.H. Graziano, G.P. White, A. Jacobs and A. Cerami: The development of new ion-chelating drugs II. J. Pharmacol. and Exptl. Therapeutics 205:757–765, 1978.
Muetterties E.L. and CM. Wright: Chelate Chemistry. I. Tropolone and aminotroponimine derivatives of the main-group elements. J. American Chem. Soc. 86:5132–5137, 1964.
Dewanjee M.K., S.A. Rao and P. Disisheim: 111-Indium-tropolone, a new high-affinity platelet label: Preparation and evaluation of labelling parameters. J. Nucl. Med. 22:981–987, 1981.
Rao S.A. and M.K. Dewanjee: Comparative evaluation of recell-labelling parameters of three lipid-soluble-111-In-chelates: Effect of lipid solubility on membrane incorporation and stability constant on transchelation. Eur. J. Nucl. Med. 7:282–285, 1982.
Danpure H.J., S. Osman and F. Brady: The labelling of blood cells in plasma with 111-In-tropolonate. Brit. J. Radiol. 55:247–249, 1982.
Pertoft H. and T.C. Laurent: Isopycnic separation of cells and cell organelles by centrifugation in modified colloidal silica gradients. In: Methods of Cell Separation, Vol. 1, edited by N. Catsimpoolas, Plenum Press, pp.25–65, 1977.
Harbeck R.J., A.A. Hoffman, S. Redecker, T. Biundo and J. Kurnick: The isolation and functional activity of polymorphonuclear leucocytes and lymphocytes separated from whole blood on a single Percoli density gradient. Clinical Immun. + Immunopathology 23:682–690, 1982.
Burke J.E.T., S. Roath, D. Ackery and P. Wyeth: The comparison of 8-hydroxyquinoline, tropolone and acetylacetone as mediators in the labelling of polymorphonuclear leucocytes with111-Indium. A Functional study. Eur. J. Nucl. Med. 7:73–76, 1982.
Scheffel U., M-F. Tsan and P.A. Mclntyre: Labelling of human platelets with (111-In) 8-hydroxyquinoline. J. Nucl. Med. 20:524–531, 1979.
Saverymuttu S.H., A.M. Peters, H.J. Reavy, H.J. Danpure, S. Osman and J.P. Lavender: The clinical use of 111-Indium-tropolone leucocytes for the detection of sepsis. Nucl. Med. Comm. 3:100 (Abstract), 1982.
Goodwin D.A., L.F. Fajardo, K.L. Frank, C.F. Meares and V. Hughot: Receptor binding, transport and metabolism of 111-Indium-radiopharmaceuticals by electron microscope autoradiography. Nucl. Med. Comm. 3:99 (Abstract), 1982.
Schroth J.J., E. Oberhausen and R. Berberich: Cell labelling with colloidal substances in whole blood. Eur. J. Nucl. Med. 6:469–472, 1981.
Zoghbi S.S., M.L. Thakur and A. Gottschalk: Selective cell labelling: A potential radioactive agent for labelling of human neutrophils. J. Nucl. Med. 22:P.32 (Abstract), 1981.
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© 1984 Martinus Nijhoff Publishers, The Hague
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Danpure, H.J., Osman, S. (1984). Labelling Blood Cells with 111-In-Tropolonate. In: Fueger, G.F. (eds) Blood cells in nuclear medicine, part II. Developments in Nuclear Medicine, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6030-5_8
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DOI: https://doi.org/10.1007/978-94-009-6030-5_8
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