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What Animal Models Should Be Used to Define Antiarrhythmic Efficacy? Acute Dog Models

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The Evaluation of New Antiarrhythmic Drugs

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 11))

Abstract

The number and diversity of animal models used to study the effectiveness of antiarrhythmic agents attests to the inadequacy of any one model to closely simulate the most frequent and important cause of sudden death in man.(1) Obviously each model is able to imitate certain aspects of the arrhythmias seen in the presence of ischemic heart disease, but significant problems have been identified in relating the arrhythmias induced in these models to those resulting from acute or chronic ischemia in man. In general, these models do not take into account such factors as prior coronary and cardiac disease, neurohumoral influences, collateral circulation, or the anatomical locations of the diseased vessels and infarcted zones, each of which may influence the susceptibility for ventricular arrhythmias to culminate in ventricular fibrillation. While the Harris(2–4) 1 stage and 2 stage coronary artery ligation models introduced more than 30 years ago remain most popular for the study of ventricular arrhythmias associated with myocardial ischemia and infarction, they have not been completely satisfactory as models for anti-arrhythmic drug testing.

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Authors
  1. Leonard S. Dreifus M.D.
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  2. Masahito Naito M.D.
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  3. Eric L. Michelson M.D.
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Editor information

Editors and Affiliations

  1. The Lankenau Hospital, Philadelphia, Pennsylvania, USA

    Joel Morganroth M.D. , Leonard S. Dreifus M.D.  & Eric L. Michelson M.D. ,  & 

  2. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    E. Neil Moore D.V.M., Ph. D.

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© 1981 Martinus Nijhojf Publishers bv, The Hague.

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Dreifus, L.S., Naito, M., Michelson, E.L. (1981). What Animal Models Should Be Used to Define Antiarrhythmic Efficacy? Acute Dog Models. In: Morganroth, J., Moore, E.N., Dreifus, L.S., Michelson, E.L. (eds) The Evaluation of New Antiarrhythmic Drugs. Developments in Cardiovascular Medicine, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8270-3_3

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  • DOI: https://doi.org/10.1007/978-94-009-8270-3_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8272-7

  • Online ISBN: 978-94-009-8270-3

  • eBook Packages: Springer Book Archive

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