Abstract
Experiments in rats and mice have shown that antigens absorbed across mucous membranes may give rise to an IgE response, or alternatively to the suppression of IgE responsiveness through the activation of immunoregulatory mechanisms. Which of these alternatives occurs seems to depend on an interaction of extrinsic factors including dose and form of antigen presentation with the intrinsic immune reactivity of the animal, which may in itself be influenced by previous events. The available evidence for these statements will be reviewed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bazin, H. and Platteau, B., 1976. Production of circulating reaginic (IgE) antibodies by oral administration of ovalbumin to rats. Immunology 30, 679.
Bazin, H. and Platteau, B., 1977. Oral feeding of ovalbumin can makerats tolerant to an intraperitoneal injection of DNP-ovalbumin and Bordetella pertussis. Biochem. Soc. Trans. 5, 1571.
Coombs, R.R.A., Devey, M.E. and Anderson, K.J., 1978. Refractoriness to anaphylactic shock after continuous feeding of cows’ milk to guinea-pigs. Clin. Exp. Immunol. 32, 263.
David, M.F., 1977. Prevention of homocytotropic antibody formation and anaphylactic sensitisation by prefeeding antigen. J. Allerg. Clin. Immunol. 60, 180.
Devey, M.E., Anderson, K.J., Coombs, R.R.A., Henschel, M.J. and Coates, M.E., 1976. A modified anaphylaxis hypothesis for cot death. Anaphylactic sensitisation in guinea-pigs fed cows milk. Clin. Exp. Immunol. 26, 542.
Gerbrandy, J.L.F. and Bienenstock, J., 1976. Kinetics and localisation of IgE tetanus antibody response in mice immunised by the intratracheal, intraperitoneal and subcutaneous routes. Immunology 31, 913.
Hanson, D.G., Vaz, N.M., Maia, L.C.S., Hornbrook, M.M., Lynch, J.M. and Roy, C.A., 1977. Inhibition of specific immune responses by feeding protein antigens. Int. Arch. Allergy 55, 526.
Hanson, D.G., Vaz, N.M., Rawlings, L.A. and Lynch, J.M., 1979a. Inhibition of specific immune responses by feeding protein antigens. II Effect of prior passive and active immunisation. J. Immunol. 122, 2261.
Hanson, D.G., Vaz, N.M., Maia, L.C.S. and Lynch, J.M., 1979b. Inhibition of specific immune responses by feeding protein antigens. III Evidence against maintenance of tolerance to ovalbumin by orally induced antibodies. J. Immunol. 123, 2337.
Hof, H., Finger, H., Korner, C. and Milke, C., 1975. Studies on the immunising capacity of orally administered particulate antigen. I Efficacy of killed Bordetella pertussis cells. Zbl Bact. Hyg. I. Abt. Orig. A. 230, 210.
Jarrett, E.E.E. and Stewart, D.C., 1974. Rat IgE Production. I Effect of dose of antigen on primary and secondary reaginic antibody responses. Immunology 27, 365.
Jarrett, E.E.E., Haig, D., McDougal, W. and McNulty, E., 1976. Rat IgE Production II. Primary and booster reaginic antibody responses following intradermal or oral immunisation. Immunology 30, 671.
Jarrett, E.E.E., 1977. Activation of IgE regulatory mechanisms by transmucosal absorption of antigen. Lancet ii 223.
Ngan, J. and Kind, L.S., 1978. Suppressor T cells for IgG and IgE in Peyers patches of mice made tolerant by oral administration of ovalbumin. J. Immunol. 120, 861.
Perelmutter, L. and Liakopoulou, A., 1975. Production of rat homocytotropic antibodies using low dose long term oral exposure to penicillin G. Acta Allergol. 30, 250.
Ratner, B. and Gruehl, H.L., 1933. Passage of native proteins through the normal gastrointestinal wall. J. Clin. Invest. 13, 517.
Siegal, S., 1956. Non parametric statistics p. 184. McGraw-Hill, Tokyo.
Van Hout, C. and Johnson, H., 1972. Synthesis of rat IgE by aerosol immunisation. J. Immunol. 108 834.
Vaz, N.M., Maia, L.C.S., Hanson, D.G. and Lynch, J.M., 1977. Inhibition of homocytotropic antibody responses in adult inbred mice by previous feeding of the specific antigen. J. Allerg. Clin. Immunol. 60, 110.
Wells, H.G. and Osborne, T.B., 1911. The biological reactions of the vegetable proteins I Anaphylaxis. J. Infect. Dis. 8, 66.
Wortmann, F., 1977. Oral hyposensitisation of children with pollinosis or house-dust asthma. Allergol et Immunopathol. 5, 15–26.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 ECSC, EEC, EAEC, Brussels-Luxembourg
About this chapter
Cite this chapter
Jarrett, E. (1981). Stimulation and Suppression of IgE Antibodies by Antigens Presented to Mucosal Surfaces. In: Bourne, F.J. (eds) The Mucosal Immune System. Current Topics in Veterinary Medicine and Animal Science, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8331-1_7
Download citation
DOI: https://doi.org/10.1007/978-94-009-8331-1_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8333-5
Online ISBN: 978-94-009-8331-1
eBook Packages: Springer Book Archive