Abstract
Transport of nuclear encoded proteins into mitochondria is mediated by distinct translocation machinery in the outer and inner mitochondrial membranes. At the outer membrane, import is facilitated by a multi-subunit complex called TOM. The role of individual TOM components in recognition and translocation of preproteins will be discussed. Specific characteristics of the protein-conducting channel and the three-dimensional structure of the TOM complex isolated from Neurospora crassa and determined by electron microscopy are described.
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Nussberger, S., Neupert, W. (2002). Protein Translocation Across the Outer Membrane of Mitochondria. In: Kasianowicz, J.J., Kellermayer, M.S.Z., Deamer, D.W. (eds) Structure and Dynamics of Confined Polymers. NATO Science Series, vol 87. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0401-5_4
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