Skip to main content

Report on tranexamic acid

  • Chapter
Haemostatic Drugs

Abstract

Tranexamic acid is the trans-isomer of 4-aminomethylcyclohexane carboxylic acid. The initial investigations were made using a preparation containing a mixture of isomers, but it was subsequently found (Melander et al. 1964; Okamoto et al., 1964) that only the trans-isomer is antifibrinolytically active.

Anvitoff®, Cyklokapron®, Exacyl®, Frénolyse®, Ugurol®.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andersson L., Nilsson I.M., Nilehn J.E., Hedner U., Granstrand B., and Melander B. (1965) Experimental and clinical studies on AMCA, the antifibrinolytically active isomer of p-aminomethyl cyclohexanecarboxylic acid. Scand. J. Haemal. 2, 230.

    Article  CAS  Google Scholar 

  • Andersson L., Nilsson I. M., Colleen S., Granstrand B. and Melander B. (1968) Role of urokinase and tissue activators in sustaining bleeding and the management thereof with EACA and AMCA. Ann. N. Y. Acad. Sci. 146, 642.

    Article  PubMed  CAS  Google Scholar 

  • Bennett A.E., Ingram G.I.C. and Inglish P.J. (1973) Antifibrinolytic treatment in haemophilia: a controlled trial of prophylaxis with tranexamic acid. Brit. J. Haemal. 24, 83.

    Article  CAS  Google Scholar 

  • Björlin G. and Nilsson I. M. (1973) Tooth extractions in hemophiliacs after administration of a single dose of factor VIII or factor IX concentrate supplemented with AMCA. Oral. Surg. 36, 482.

    Article  PubMed  Google Scholar 

  • Callender S.T., Warner G.T. and Cope E. (1970) Treatment of menorrhagia with tranexamic acid. A double-blind trial. Brit. med. J. iv, 214.

    Article  Google Scholar 

  • Cormack F., Jaeher A.J., Chakrabarti R.R. and Fearnley G.R. (1973) Tranexamic acid in upper gastrointestinal haemorrhage. Lancet i, 1207.

    Article  Google Scholar 

  • Davies D. and Howell D. A. (1977) Tranexamic acid and arterial thrombosis. Lancet i, 49.

    Article  Google Scholar 

  • Dubber A.H.C., Mcnicol G.P., Douglas A.S. and Melander B. (1964) Some properties of the antifibrinolytically active isomer of aminomethylcyclohexane carboxylic acid. Lancet ii, 1317.

    Article  CAS  Google Scholar 

  • Dubber A.H.C., Mcnicol G.P. and Douglas A.S. (1965) Aminomethylcyclohexane carboxylic acid (AMCA), a new synthetic fibrinolytic inhibitor. Brit. J. Haemat. 11, 237.

    Article  PubMed  CAS  Google Scholar 

  • Forbes C.D., Barr R.D., Reid G., Thomson C, Prentice C.R., Mcnicol G.P. and Douglas A.S. (1972) Tranexamic acid in control of hemorrhage after dental extraction in haemophilia and Christmas disease. Brit. med. J. ii, 311.

    Article  Google Scholar 

  • Gebauer D. and Heigel K. (1969) Therapeutische Beeinflussung der Hämophilie durch AMCHA. Med. Klin. 64, 378.

    PubMed  CAS  Google Scholar 

  • Gibbs J.R. and Corkill A.G.L. (1971) Use of an anti-fibrinolytic agent (tranexamic acid) in the management of ruptured intracranial aneurysms. Postgrad, med. J. 47, 199.

    Article  CAS  Google Scholar 

  • Groth P. (1968) Crystal structure of the trans form of 1,4 aminomethylcyclohexanecarboxylic acid. Acta chem. scand. 22, 143.

    Article  PubMed  CAS  Google Scholar 

  • Hedlund P.O. (1969) Antifibrinolytic therapy with Cyclokapron in connection with prostatectomy. A double-blind study. Scand. J. Urol. Nephrol. 3, 177.

    Article  PubMed  CAS  Google Scholar 

  • Kadoya S., Hanazaki F. and Iitaka Y. (1966) The crystal structures of trans-and cis-4 aminomethylcyclohexane-1-carboxylic acid hydrohalides. Acta Cryst. 21, 38.

    Article  CAS  Google Scholar 

  • Kaller H. (1967) Enterale Resorption, Verteilung und Elimination von 4-Aminomethylcyclohexancarbonsäure (AMCHA) und É›-Aminocapronsäure (ACS) beim Menschen. Naunyn Schmiedeberg’s Arch. Pharmak. exp. Pathol. 256, 160.

    Article  CAS  Google Scholar 

  • Kullander S. and Nilsson I.M. (1970) Human placental transfer of an antifibrinolytic agent (AMCA). Acta obstet, gynecol. scand. 49, 241.

    Article  CAS  Google Scholar 

  • Maki M. and Beller F.K. (1966) Comparative studies of fibrinolytic inhibitors in vitro. Thrombos. Diathes. haemorrh. (Stuttg.) 16, 668.

    CAS  Google Scholar 

  • Melander B., Gliniecki G., Granstrand B. and Hanshoff G. (1964) Experimental studies on the antifibrinolytic activity of AMCHA (Abstr. G 68), X Congr. Int. Soc. Haemat., Stockholm.

    Google Scholar 

  • Melander B., Gliniecki G., Granstrand B. and Hanshoff G. (1965) Biochemistry and toxicology of aminokapron; the antifibrinolytically active isomer of AMCHA. Acta pharmacol. (Kbh.) 22, 340.

    Article  CAS  Google Scholar 

  • Nilsson L. and Rybo G. (1967) Treatment of menorrhagia with epsilon aminocaproic acid. Acta obstet, gynecol. scand. 46, 572.

    Article  Google Scholar 

  • Okamoto S., Kinjo K., Oshiba S., Mangyo M., Shimizu M., Sato S. and Okamoto U. (1964) Behavior of tissue activators and the action of a series of potent inhibitors of fibrinolysis (Abstr. G 65). X Congr. Int. Soc. Haemat., Stockholm.

    Google Scholar 

  • Petruson B. (1974) Acta Otolaryng., suppl. 317

    Google Scholar 

  • Rainsford S.G., Joahar A.J. and Hall A. (1973) Tranexamic acid in the control of spontaneous bleeding in severe haemophilia. Thrombos Diathes. haemorrh. (Stuttg.) 30, 272.

    CAS  Google Scholar 

  • Rö J. S., Knutro O. and Stormorken H. (1970) Antifibrinolytic treatment with tranexamic acid (AMCA) in pédiatrie urinary tract surgery. J. pediat. Surg. 5, 315.

    Article  PubMed  Google Scholar 

  • Rybo G. and Westerberg H. (1972) The effect of tranexamic acid (AMCA) in postoperative bleeding after conization. Acta obstet, gynecol. scand. 51, 347.

    Article  CAS  Google Scholar 

  • Rydin E. and Lundberg P. O. (1976) Tranexamic acid and intracranial thrombosis. Lancet ii, 49.

    Article  Google Scholar 

  • Steenblock D.A. and Celander D.R. (1968) A light and electron microscopic study of arteries and other tissues from dogs subjected to chronic fibrinolytic inhibition with AMCHA. Vasc. Surg. 2, 149.

    PubMed  CAS  Google Scholar 

  • Vermylen J., Verhaegen-Declercq M.L., Verstraete M. and Fierens F. (1968) A double-blind study of the effect of tranexamic acid in essential menorrhagia. Thrombos. Diathes. haemorrh. (Stuttg.) 20, 584.

    Google Scholar 

  • Verstraete M., Tyberghein J., DE Greef Y., Daems L. and VAN Hoof A. (1977) Double-blind trials with ethamsylate, batroxobin or tranexamic acid on blood loss after adenotonsillectomy. Acta clin. belg. 32, 136.

    PubMed  CAS  Google Scholar 

  • Westrom L. and Bengtsson L.P. (1970) Effect of tranexamic acid (AMCA) in menorrhagia with intrauterine contraceptive devices. A double-blind study. J. Reprod. Med. 5, 154.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Martinus Nijhoff, P.O.B. 442, The Hague, The Netherlands

About this chapter

Cite this chapter

Verstraete, M. (1977). Report on tranexamic acid. In: Haemostatic Drugs. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1106-8_29

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-1106-8_29

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-247-2020-0

  • Online ISBN: 978-94-010-1106-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics