Abstract
The inhibitory effect of topically applied flurbiprofen, a newer non-steroidal anti-inflammatory agent, on prostaglandin biosynthesis in human skin biopsies in primary irritant dermatitis was examined. The flurbiprofen treated areas synthesized significantly less PGE1 (279 pg/mg dry weight) than placebo treated inflamed skin (626 pg/mg dry weight). The average inhibition in 11 treated patients was 55% (p < 0.01 using Wilcoxon’s signed rank test). Furthermore, when the anti-inflammatory effect of flurbiprofen was clinically evaluated, a poor correlation was found between the reduction of prostaglandin synthesis and the clinical effects of flurbiprofen.
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© 1980 MTP Press Limited
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Kassis, V. (1980). Effect of flurbiprofen on prostaglandin synthesis (Abstract). In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_92
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DOI: https://doi.org/10.1007/978-94-010-9423-8_92
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9425-2
Online ISBN: 978-94-010-9423-8
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