Abstract
Almost 15 years have elapsed since the proposal was put forward to administer some corticosteroids in a special way which is called pulse therapy. This consists in administering intravenously single doses of methylprednisolone which are about ten times greater than the highest doses given daily when using traditional methods. After the interesting results in the treatment of renal transplant rejection were reported1–3, corticosteroid pulse therapy was applied in the treatment of patients with lupus nephritis4–10, those with poli-dermatomyositislr11, those with rheumatoid arthritis12,13 and those suffering from ankylosing spondylitis14,15.
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References
Bell, PRF, Briggs, JD, Calman, KG, Paton, AM, Wood, RFM, MacPherson, SG and Kyle, K (1971). Reversal of acute clinical and experimental organ rejection using large doses of intravenous prednisolone. Lancet, 1, 876
Turcotte, J Feduska, N, Carpenter, E, McDonald, F and Bacon, G (1972). Rejection crises in human renal transplant recipients. Arch Surg, 105, 230
Clarke, AG and Salaman, JR (1974). Methylprednisolone in the treatment of renal transplant rejection. Clin Nephrol, 2, 230
Cathcart, ES, Idelson, BA, Scheinberg, MA and Couser, WG (1976). Beneficial effects of methylprednisolone “pulse” therapy in diffuse proliferative lupus nephritis. Lancet, 1, 163
Ponticelli, C, Tarantino, A, Piotelli, P and Invernizzi, F (1977). High dose methylprednisolone pulses in active lupus nephritis. Lancet, 1, 1063
Kimberly, RP, Lockshin, MD, Sherman, RL, McDougal, JS, Inman, RL and Christian, CL (1981). High dose intravenous methylprednisolone pulse therapy in systemic lupus erythematosus. Am J Med, 70, 817
Isenberg, DA, Morrow, WJW and Snaith, ML (1982). Methylprednisolone pulse therapy in the treatment of systemic lupus erithematosus. Ann Rheum Dis, 41, 347
Liebling, MR, McLaughin, K, Boonsue, S, Kasdin, J and Barnett, EV (1982). Monthly pulses of methylprednisolone in SLE nephritis. J Rheumatol, 9, 543
Marmont, A (1983). Lupus eritematoso sistemico. In: Introzzi, P (ed.), Trattato Italiano di Medicina Interna, Parte X, 3rd edn. ( Firenze: USES ), p. 577
Tirri, G, Migliaresi, S, Picillo, U, Improta, R, Tirri, R and Giordano, M (1983). Methylprednisolone pulse therapy for systemic lupus erythematosus a study of 11 cases). Conn Tiss Dis, 2, 107
Yanagisawa, T, Sueiski, M, Namata, Y, Akimoto, T, Nozaki, T, Koike, T, Tomiska, H and Kumagai, A (1983). Methylprednisolone pulse therapy in dermatomyositis. Dermatologica, 167, 47
Williams, IA, Baylis, EM and Shipley, ME (1982). A double-blind placebo controlled trial of methylprednisolone pulse therapy in active rheumatoid disease. Lancet, 2, 237
Liebling, MR, Lieb, E and McLaughin, K (1981). Pulse methylprednisolone in rheumatoid arthritis: a double-blind cross-over trial. Ann Intern Med, 94, 21
Mintz, G, Enriques, RD, Mercado, U, Robles, EJ, Jimenez, FJ and Gutierrez, G (1981). Intravenous methylprednisolone pulse therapy in severe ankylosing spondylitis. Arthritis Rheum, 24, 734
Richter, ME, Woop, P, Panay, GS, Trull, A, Unger, A and Shepherd, P (1983). The effect of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis. Clin Exp Immunol, 53, 51
Fessel, WJ (1980). Megadose corticosteroid therapy in systemic lupus erythematosus. J Rheumatol, 7, 486
Eyanson, S, Passo, MM, Aldo-Benson, MA and Benson, MD (1980). Methylpred- nisolone pulse therapy for nonrenal lupus erythematosus. Ann Rheum Dis, 39, 377
Tan, EM, Cohen, AS, Fries, JF, Masi, AT, McShane, DJ, Rothfield, NF, Shaller, JG, Talal, N and Winchester, RJ (1982). The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum, 25, 1271
Stubbs,SS and Morrel, RM (1973). Intravenous methylprednisolone sodium succinate: adverse reactions reported in association with immunosuppressive therapy. Transplant Proc, 5, 1145
Bocanegra, TS, Castaneda, MO, Espinoza, LR, Vasey, FB and Germain, BF (1981). Sudden death after methylprednisolone pulse therapy (letter). Ann Intern Med, 95, 122
Warren, DJ and Smith, RS (1983). High dose prednisolone. Lancet, 1, 594
Barrett, DF (1983). Pulse methylprednisolone therapy (letter). Lancet, 2, 800
Anonymous (1983). Prednisolone pulse in collagen disease: grammes or milligrammes? (Editorial). Lancet, 1, 280
Garret, R and Paulus, H (1980). Complications of intravenous methylprednisolone pulse therapy ( Abstracts ). Arthritis Rheum, 23, 677
Boghossian, SH, Isenberg, DA, Wright, G, Smith, ML, Segal, AW (1984). Effect of high-dose methylprednisolone therapy on phagocite function in systemic lupus erythematosus. Ann Rheum Dis, 43, 541
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Giordano, M., Tirri, G., Migliaresi, S., Picillo, U., Improta, D.G. (1987). Side-effects in SLE patients treated with methylprednisolone pulse therapy (MPPT). In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs. Inflammation and Drug Therapy Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9775-8_33
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DOI: https://doi.org/10.1007/978-94-010-9775-8_33
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