Abstract
This overview will address the current state-of-the-art in characterising metal ionoligonucleotide interaction by NMR spectroscopy. First the methodology of structure determination of oligonucleotides — metal ion complexes in solution will be discussed. In the second part recent results on sequence-selective metal ion binding to DNA oligonucleotides by NMR methods will be presented. Metal ion titrations of several dodecamer duplexes have been carried out using Mn(II), Zn(II), Hg(II) and Pd(II) salts. The selectivity is shown to be determined by the sequential variation in molecular electrostatic potential along the chain and also to a certain degree by the preferred coordination geometry of the metal ion.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Sip, M., Schwartz, A., Vovelle, F., Ptak, M. and Leng, M. Biochemistry, 1992, 31, 2508.
Narasimhan, V. and Bryan, A. M. Inorg. Chim. Acta , 1984, 91, L39.
Eichhorn, G. L. and Shin, Y. A., J. Am. Chem. Soc., 1968, 90, 7323.
Chuprina, V.P., Sletten, E., and Fedoroff, O.Y. J.Biomol.Struct. Dyn., 1993, 10, 693.
Wang, A. C, Kim, S. G., Flynn, P. F., Sletten, E., and Reid, B. R. J. Magn. Reson., 1992,100, 358.
Young, P. R., Nandi, U. S. and Kallenback, N., R. Biochemistry, 1982, 21, 62
Buchner, P., Maurer, W. and Ruterjans, H. J. Magn. Reson., 1978, 29, 45.
Nee, M. and Roberts, J. D. Biochemistry, 1982, 21, 4929.
Buchanan, G. W. and Bell, M. J. Can. J. Chem., 1983, 61, 2445.
Frøystein, N. Ă. and Sletten, E. J. Am. Chem. Soc. (in press)
Kowalewski, J., Nordenskiøld, L., Benetis, N and Westlund, P. O. 1985 Prog. NMR Spectroscopy 17, 141.
Nerdal, W., Hare, D. R. and Reid, B. R. Biochemistry, 1989, 28, 10008.
Taylor, J. D. and Halford, S. E., Biochemistry , 1989,28, 6198.
Eichhorn, G. L. In: Eichhorn, G. L., Ed. Inorganic Bioshemistry, Elsevier, Amsterdam, 1973, Vol. 2, Chap. 33–34.
Sletten, E. and Lie, B. Acta. Cryst, 1976, B32, 3301.
Furst, A., Environ. Health Persp., 1981, 40, 83.
Frøystein, N. Ă. and Sletten, E. Acta Chem. Scand, 1991,45, 219.
Frøystein, N. Ă., Davis, J. T., Reid, B. R. and Sletten, E. Acta Chem. Scand, 1993,47, 649.
Jia, X, Zon, G., and Marzilli, G. L. Inorg. Chem., 1991,30, 228.
Pullman, A. and Pullman, B. Q. Rev. Biopfys., 1981, 14, 289.
Wurdeman, R. L., Church, K. M., and Gold, B. J. Am. Chem. Soc., 1989,777, 6408.
Kohn, K. W., Hartley, J. A., and Mattes, W. B. Nucl. Acid Res. 1987, 15, 10531.
Yamane, T. and Davidson, N. J. Am. Chem. Soc. 1961, 83, 2599.
Gruenwedel, D.W. and Cruikshank, M. K. Biochemistry, 1990, 29, 2110.
Frøystein, N. Ă. and Sletten, E. J. Am. Chem. Soc., 1994,116, 3240.
Sherman, S. E. and Lippard, S. J. Chem. Rev., 1987,87, 1153.
Reedijk, J. Inorg. Chim. Acta , 1992,198–200, 873.
Kozelka, J., Fouchet, M. H. and Chottard, J.C. Eur. J. Biochem., 1992, 205, 895.
Garoufis, A., Frøystein, N. Ă. and Sletten, E. (to be submitted)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Sletten, E., Frøystein, N.Ă. (1995). NMR Spectroscopic Structure Determination of Metal Ion — Oligonucleotide Complexes — The Results of Sequence-Selective Binding Studies. In: Kessissoglou, D.P. (eds) Bioinorganic Chemistry. NATO ASI Series, vol 459. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0255-1_13
Download citation
DOI: https://doi.org/10.1007/978-94-011-0255-1_13
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-4113-3
Online ISBN: 978-94-011-0255-1
eBook Packages: Springer Book Archive