Abstract
Quinidine is the dextro-rotatory isomer of quinine obtained from the bark of the Cinchona tree. It is used as a class la antiarrhythmic agent and has antimuscarinic and α-adrenoceptor blocking activity. It is readily absorbed orally and metabolized mainly by hydroxylation in liver to active metabolites. Excretion of parent compound (20%) and metabolites is by the kidney. The half-life in plasma is 4-12 hours. Therapeutic concentrations in plasma are 2-6 μg/ml but there is considerable intersubject variability. Concentrations > 15 μg/ml produce gastrointestinal or cardiovascular toxicity in 50% of patients.
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© 1995 Springer Science+Business Media New York
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Wilson, J.F. (1995). Quinidine. In: Wilson, J.F. (eds) Drugs Eicosanoids. Immunoassay Kit Directory, vol 1 / 3 / 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0679-5_46
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DOI: https://doi.org/10.1007/978-94-011-0679-5_46
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-8863-0
Online ISBN: 978-94-011-0679-5
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