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Apolipoprotein E Polymorphism and Atherosclerosis Risk

  • Chapter
Genetic factors in coronary heart disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 156))

Abstract

Apolipoprotein E (apoE) is a normal constituent of very low density lipoprotein (VLDL) and high density lipoprotein (HDL)1. The primary function of apoE is to serve as the ligand for recognition of lipoproteins by cellular receptors2. In addition, apoE interacts with various proteoglycans and could thus be implicated in the anchoring process of lipoproteins to endothelial lipases3. ApoE is a 299 amino acid protein made of two folded structural domains5. The NH2-terminal region (residues 1–191) binds to the LDL receptor. Studies with cyanogen bromide and thrombolytic fragments of apoE, and with anti-apoE monoclonal antibodies, have demonstrated that the LDL-receptor-binding domain is located between residues 130 and 1501. A cluster of basic residues in this region of apoE binds through direct ionic interaction with the negatively charged residues of the ligand-binding domain of the LDL receptor.

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Authors and Affiliations

  1. Département d’Etudes des Lipides et des Lipoprotéines, Institut Pasteur de Lille, 1 rue du Professeur Calmette, P.O. Box 245, F-59019, Lille Cedex, France

    Jean Dallongeville

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  1. Jean Dallongeville
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Editors and Affiliations

  1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt (Professor of Epidemiology and Preventive Medicine, Head) (Professor of Epidemiology and Preventive Medicine, Head)

  2. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf de Faire (Professor) (Professor)

  3. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    Kåre Berg (Professor of Medicine, Chairman, Director and Physician-in-Chief) (Professor of Medicine, Chairman, Director and Physician-in-Chief)

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© 1994 Springer Science+Business Media Dordrecht

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Dallongeville, J. (1994). Apolipoprotein E Polymorphism and Atherosclerosis Risk. In: Goldbourt, U., de Faire, U., Berg, K. (eds) Genetic factors in coronary heart disease. Developments in Cardiovascular Medicine, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1130-0_19

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  • DOI: https://doi.org/10.1007/978-94-011-1130-0_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4494-3

  • Online ISBN: 978-94-011-1130-0

  • eBook Packages: Springer Book Archive

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