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Lipids, Apolipoproteins and Lipoproteins

  • Chapter
Genetic factors in coronary heart disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 156))

Abstract

Lipids are transported in the circulation by lipoproteins, macromolecular complexes that consist of lipids (unesterified and esterified cholesterol, triglycerides, and phospholipids) and proteins, termed apolipoproteins. Apolipoproteins serve a variety of physiological functions in lipoprotein metabolism, including cofactors for enzymes, ligands for cell-surface receptors, and structural proteins for lipoprotein biosynthesis. A summary of the major apolipoproteins and their known functions is provided in Table 6.1 (reviewed in Reference 1).

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  1. Institute for Human Gene Therapy, 601 Maloney, University of Pennsylvania Medical Center, 3400 Spruce St., Philadelphia, PA, 19104, USA

    Daniel J. Rader & H. Bryan Brewer Jr.

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  1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt (Professor of Epidemiology and Preventive Medicine, Head) (Professor of Epidemiology and Preventive Medicine, Head)

  2. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf de Faire (Professor) (Professor)

  3. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    KÃ¥re Berg (Professor of Medicine, Chairman, Director and Physician-in-Chief) (Professor of Medicine, Chairman, Director and Physician-in-Chief)

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Rader, D.J., Brewer, H.B. (1994). Lipids, Apolipoproteins and Lipoproteins. In: Goldbourt, U., de Faire, U., Berg, K. (eds) Genetic factors in coronary heart disease. Developments in Cardiovascular Medicine, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1130-0_6

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