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Toxic and non-toxic nonprotein amino acids in the Vicieae

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Amino Acids

Abstract

Over 665 nonprotein amino acids have been recognized as secondary metabolites. Forty-two of these natural products were found in members of the Vicieae. The highest concentrations of such compounds, and often the greatest variety, may be found in young seedlings of the genera: Lathyrus, Vicia, Lens and Pisum.

Relatively high concentrations of isoxazolinone amino acids are found characteristically in all species and varieties of Pisum and Lens, and in most species of Lathyrus and in part of the Vicia species. Outside the tribe Vicieae, isoxazolinone derivatives are not found in the plant kingdom.

Of the fifty species of Lathyrus seedlings examined, forty contain isoxazolinone amino acids. The analysis of these seedlings mostly reveal unique compositions of nonprotein amino acids and derivatives, including up to nine isoxazolinone derivatives, homoarginine, lathyrine, homoserine, O-acetyl-homoserine, O-oxalyl-homoserine, the osteolathyrogen: 3-aminopropionitrile and its 4-glutamyl derivative as well as the neurotoxins 2,4-diaminobutyric acid and 3-N-oxalyl-2,3-diaminopropionic acid.

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Authors and Affiliations

  1. Lab. of Physiological Chemistry, State University of Gent, K.L. Ledeganckstraat 35, B-9000, Gent, Belgium

    Fernand Lambein & Yu-Haey Kuo

  2. Facuity of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Chiba, 260, Japan

    Fumio Ikegami & Isamu Murakoshi

Authors
  1. Fernand Lambein
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  2. Yu-Haey Kuo
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  3. Fumio Ikegami
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  4. Isamu Murakoshi
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, University of Vienna, A-1090, Vienna, Austria

    Gert Lubec

  2. T. H. Morgan School of Biological Sciences and The Graduate Center for Toxicology, University of Kentucky, 40506-0225, Lexington, Kentucky, USA

    Gerald A. Rosenthal

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© 1990 ESCOM Science Publishers B.V.

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Lambein, F., Kuo, YH., Ikegami, F., Murakoshi, I. (1990). Toxic and non-toxic nonprotein amino acids in the Vicieae. In: Lubec, G., Rosenthal, G.A. (eds) Amino Acids. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2262-7_3

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  • DOI: https://doi.org/10.1007/978-94-011-2262-7_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-72199-04-1

  • Online ISBN: 978-94-011-2262-7

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