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Human pharmacogenetics of nitrogen oxidations

  • Chapter
N-Oxidation of Drugs

Abstract

Drug and foreign compound biotransformations are mediated by a group of enzymes known collectively as the ‘drug-metabolizing enzymes’. These include the microsomal mixed function mono-oxygenases, commonly referred to as the cytochrome P-450s but also several non-cytochrome P-450 enzymes including the cytosolic alcohol dehydrogenase and the microsomal flavin-containing mono-oxygenase, otherwise known as Ziegler’s enzyme. Although such enzymes mediate the oxidation of xenobiotic compounds, many of them also have a known physiological role. Their activity is associated largely with the liver, however their presence has also been demonstrated in other tissues including lung, kidney and intestine. Furthermore, the enzymes of the gut flora are also known to be important mediators of the metabolism of certain xenobiotics.

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  1. S. Cholerton

    Present address: Department of Pharmacological Sciences, The Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, St Mary’s Hospital Medical School, Norfolk Place, London, W2 1PG, UK

    S. Cholerton & R. L. Smith

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  1. S. Cholerton
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Editors and Affiliations

  1. Ludwig-Maximilians-Universität München, Munich, Germany

    P. Hlavica (Full Professor of Pharmacology and Toxicology) (Full Professor of Pharmacology and Toxicology)

  2. Chelsea Department of Pharmacy, King’s College, University of London, UK

    L. A. Damani (Lecturer in Biopharmacy) (Lecturer in Biopharmacy)

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Cholerton, S., Smith, R.L. (1991). Human pharmacogenetics of nitrogen oxidations. In: Hlavica, P., Damani, L.A. (eds) N-Oxidation of Drugs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3112-4_7

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  • DOI: https://doi.org/10.1007/978-94-011-3112-4_7

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