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The cytochrome P450 supergene family: genetic organization and function

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Immunology and Liver

Part of the book series: Falk Symposium ((FASS,volume 114))

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Abstract

At least eight human cytochrome P450s are recognized by autoantibodies associated with either alcoholic liver disease, autoimmune polyendocrinopathy, autoimmune hepatitis or drug-induced autoimmunity (Table 1). The poly specific responses to both conformational and linear epitopes that have been characterized for autoantibodies to P450 2D6 in LKM-1-positive autoimmune hepatitis suggests that the autoimmune response is directed towards the P4501-7. Although the other P450 antigens listed in Table 1 have not yet received the same level of scrutiny, these enzymes nevertheless appear to be relatively specific targets for autoimmune responses.

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Authors
  1. K. J. Griffin
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  2. E. F. Johnson
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Editors and Affiliations

  1. Abt. Gastroenterologie/Hepatologie Zentrum Innere Medizin, Medizinische Hochscule Hannover, Carl-Neuberg Str. 1, D-30625, Hannover, Germany

    M. P. Manns

  2. Medizinische Klinik II, Klinikum Grosshadern der LMU München, Marchioninistr. 15, D-81377, München, Germany

    G. Paumgartner

  3. Abt. Gastroenterologie Zentrum der Innere Medizin, Klinikum der Johann-Wolfgang-Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, D-60596, Frankfurt, Germany

    U. Leuschner

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Griffin, K.J., Johnson, E.F. (2000). The cytochrome P450 supergene family: genetic organization and function. In: Manns, M.P., Paumgartner, G., Leuschner, U. (eds) Immunology and Liver. Falk Symposium, vol 114. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4000-3_15

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  • DOI: https://doi.org/10.1007/978-94-011-4000-3_15

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