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Origin of Synapses: A Scientific Account or the Story of a Hypothesis

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Astrobiology
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Abstract

Synapses are the structural components developed by nature to allow neuronal communication and consequently they are the fundamental sites at which the integrative functions of the central nervous system, such as intelligence and others activities of integration of less importance, are carried through. In this contribution, from both phylogenetic and ontogenetic points of view, the origin of synapses was analyzed and commented in relation to the evolution of intelligence on Earth, herein interpreted as the capacity of matter to understand matter. This approach could also be useful for the comprehension of extraterrestrial intelligence.

Centro de Microscopía Electrónica, Universidad de Los Andes, P. O. Box 163, Mérida 5101-A, Venezuela.

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References

  • Adam, G., Matus, A. (1996) Role of actin in the organization of brain postsynaptic densities. Mol. Brain Res. 43: 246–250.

    Article  PubMed  CAS  Google Scholar 

  • Altman, J. (1971) Coated vesicles and synaptogenesis. A developmental study in the cerebellar cortex of the rat. Brain Res. 30: 311–322.

    Article  PubMed  CAS  Google Scholar 

  • Apperson, M. L., Moon, L. S. and Kennedy, M. B. (1996) Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. J. Neurosci. 16: 6839–6852.

    PubMed  CAS  Google Scholar 

  • Beesly, W. P. (1989) Mini Review: Immunological approaches to the study of synaptic glycoproteins. Comp. Biochem. Physiol. 93: 255–266.

    Article  Google Scholar 

  • Bullock, T. H. and Horridge, G. A. (1965) Structure and Function in the Nervous Systems of Invertebrates. Vol. 1 and II. W.H. Freeman and Company. Netherlands.

    Google Scholar 

  • Burgin, K. E., Waxham, M. N., Rickling, S., Westgate, S. A., Mobley, W. C. and Kelly, P. T. (1990) In situ hybridization histochemistry of Ca++/calmodulin-dependent protein kinase in developing rat brain. J. Neurosci. 10: 1788–1798.

    PubMed  CAS  Google Scholar 

  • Burry, R. W. (1980) Formation of apparent presynaptic elements in response to polybasic compounds. Brain Res.184:85–98.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, R. S., Blomberg, F., Berzins, K. and Siekevitz, P. (1977) The structure of postsynaptic densities isolated from dog cerebral cortex. I. Overall morphology and protein composition. J. Cell Biol. 74: 181–203.

    Article  PubMed  CAS  Google Scholar 

  • Eckenhoff, M. P. and Pysh, J. J. (1979) Double-walled coated vesicle formation: evidence for massive and transient conjugate internalization of plasma membranes during cerebellar development. J. Neurocytol. 8: 623–638.

    Article  PubMed  CAS  Google Scholar 

  • Hunt, C. A., Schenker, L. J. and Kennedy, M. B. (1996) PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at fbrebrain synapses. J. Neurosci. 16: 1380–1388.

    PubMed  CAS  Google Scholar 

  • Jacobson, M. (1991) Developmental Neurobiology. Plenum Press, New York.

    Book  Google Scholar 

  • Kelly, P. T. and Cotman, C. W. (1981) Developmental changes in morphology and molecular composition of isolated synaptic junctional structures. Brain Res. 206: 251–271.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, M. B., Bennett, M. K. and Erondu, N. G. (1983) Biochemical and immunological evidence that the “major postsynaptic density protein” is a subunit of a calmodulin-dependent protein kinase. Proc. Natl. Acad. Sci. USA 80: 7357–7361.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, M. B. (1997) The postsynaptic density at glutamatergic synapses. Trends Neurosci. 20: 264–268.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, M. B. (1998) Signal transduction molecules at the glutamatergic postsynaptic membrane. Brain Res. Rev. 26: 243–257.

    Article  PubMed  CAS  Google Scholar 

  • Larramendi, L. M. H. (1969) Analysis of synaptogenesis in the cerebellum of the mouse In Neurobiology of Cerebellar Evolution and Development, ed. R. Llinás (Am. Med. Assoc. Educ. Res. Found., Chicago), pp. 803–843.

    Google Scholar 

  • Lentz, T. L. (1967) Primitive Nervous System. Yale University Press, U.S.A.

    Google Scholar 

  • Levine III, H. and Sahyoun, N. E. (1988) Two types of brain calmodul in-dependent protein kinase II: Morphological, biochemical and immunocytochemical properties. Brain Res. 439: 47–55.

    Article  PubMed  CAS  Google Scholar 

  • Matus, A. (1981) The postsynaptic density. Trends Neurosci. 4: 51–53.

    Article  Google Scholar 

  • Miranda-Contreras, L. and Palacios-Prü, E. L. (1995) Existence of a putative specific postsynaptic density protein produced during Purkinje cell spine maturation. Int. J. Dev. Neurosci. 13: 403–416.

    Article  PubMed  CAS  Google Scholar 

  • Palacios-Prü, E. L., Palacios, L. and Mendoza, R. V. (1976a) In vitro vs in situ development of Purkinje cell. J. Neurosci. Res. 2: 357–362.

    Article  PubMed  Google Scholar 

  • Palacios-Prü, E. L., Palacios, L. and Mendoza, R. V. (1976b) Formación de circuitos neuronales in vitro. I. Análisis con el método de Golgi de cultivos rotatorios íntégras de cerebelo. Acta Cient. Venezolana 27:301–308.

    Google Scholar 

  • Palacios-Prü, E. L., Palacios, L. and Mendoza, R. V. (1978a) Formación de circuitos neuronales in vitro. III. Análisis ultraestructural de cultivos histotípicos de cerebelo y médula espinal. Acta Cient. Venezolana 28: 19–29.

    Google Scholar 

  • Palacios-Prü, E. L., Palacios, L. and Mendoza, R. V. (1978b) Cultivos neuronales histotípicos: significación y perspectivas. Acta Cient. Venezolana 29: 295–308.

    Google Scholar 

  • Palacios-Prü, E. L., Palacios, L. and Mendoza, R. V. (1981) Synaptogenetic mechanisms during chick cerebellar cortex development. J. Submicrosc. Cytol. 13: 145–167.

    PubMed  Google Scholar 

  • Palacios-Prü, E. L., Miranda-Contreras, L., Mendoza, R. V. and Zambrano, E. (1988) Dendritic RNA and postsynaptic density formation in chick cerebellar synaptogenesis. Neuroscience 24: 111–118.

    Article  PubMed  Google Scholar 

  • Pearse, B. (1980) Coated vesicles. Trends Biochem. Sci. 5: 131–134.

    Article  CAS  Google Scholar 

  • Rees, R. P., Bunge, M. B. and Bunge, R. P. (1976) Morphological changes in the neuritic growth cone and target neuron during synaptic junction development in culture. J. Cell Biol. 68: 240–263.

    Article  PubMed  CAS  Google Scholar 

  • Roche, K. W, Dune Ly. C., Petralia, R. S., Wang, Y. X., McGee, A. W., Bredt, D. S. and Wenthold, R. J. (1999) Postsynaptic density-93 interacts with the δ2 glutamate receptor submit at parallel fiber synapses. J. Neurosci. 19: 3926–3934.

    PubMed  CAS  Google Scholar 

  • Sahyoun, N., Levine III, H., McDonald, O. B. and Cuatrecasas, P. (1986) Specific postsynaptic density proteins bind tubulin and calmodul in-dependent protein kinase type II. J. Biol. Chem. 261: 12339–12344.

    PubMed  CAS  Google Scholar 

  • Siekevitz, P. (1985) The postsynaptic density: A possible role in long-lasting effects in the central nervous system. Proc. Natl. Acad. Sci. USA 82: 3494–3498.

    Article  PubMed  CAS  Google Scholar 

  • Stelzner, D. J., Martin, A. H. and Scott, G. L. (1973) Early stages of synaptogenesis in the cervical spinal cord of the chick embryo. Z. Zeilforsch. 138: 475–488.

    Article  CAS  Google Scholar 

  • Steward, O. (1986) Protein synthesis under dendritic spine synapses during lesion-induced synaptogenesis. Evidence for regulation of reinnervation by target cell. Exp. Brain Res. 13: 173–188.

    Article  CAS  Google Scholar 

  • Steward, O., Davis, L., Dotti, C., Phillips, L. I., Rao, A. and Banker, G. (1988) Protein synthesis and processing in cytoplasmic microdomains beneath postsynaptic sites on CNS neurons. Mol. Neurobiol. 2:226–227.

    Article  Google Scholar 

  • Steward, O and Banker, A. (1992) Getting the message from the gene to the synapse: sorting and intracellular transport of RNA in neurons. Trends Neurosci. 15: 180–186.

    Article  PubMed  CAS  Google Scholar 

  • Steward, O. (1995) Targeting of mRNAs to subsynaptic microdomains in dendrites. Current Opinion in Neurobiology 5: 55–61.

    Article  PubMed  CAS  Google Scholar 

  • Torre, E, and Steward, O. (1996) Protein synthesis within dendrites: Glycosylation of newly synthesized proteins in dendrites of hippocampal neurons in culture. J. Neurosci. 16: 5967–5978.

    PubMed  CAS  Google Scholar 

  • Vaughn, J. E. (1989) Review: Fine structure of synaptogenesis in the vertebrate central nervous system. Synapse 1: 255–285.

    Article  Google Scholar 

  • Verity, M. A., Brown, W. J. and Cheung, M. (1980) Isolation of ribosome containing synaptosomes subpopulation with active in vitro protein synthesis. J. Neurosci. Res. 5: 143–153.

    Article  PubMed  CAS  Google Scholar 

  • Walsh, M. J. and Kuruc, N. (1992) The postsynaptic density: Constituent and associated proteins characterized by electrophoresis, immunoblotting, and sequencing. J. Neurochem. 59: 667–678.

    Article  PubMed  CAS  Google Scholar 

  • Westfall, J. A., Kinnamon, J. C. and Sims, D. C. (1980) Neuro-epitheliomuscular cell and neuro-neuronal gap junctions in Hydra. J. Neurocytology 9: 725–732.

    Article  CAS  Google Scholar 

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Palacios-PrÜ, E. (2000). Origin of Synapses: A Scientific Account or the Story of a Hypothesis. In: Chela-Flores, J., Lemarchand, G.A., Oró, J. (eds) Astrobiology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4313-4_16

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  • DOI: https://doi.org/10.1007/978-94-011-4313-4_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5865-0

  • Online ISBN: 978-94-011-4313-4

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