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Role of Oxidative Stress, Cytokines, and Apoptosis in Myocardial Dysfunction

  • Chapter
Antioxidants and Cardiovascular Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 233))

  • 127 Accesses

Abstract

The myocardium is highly metabolically active and rich in reactive oxygen and nitrogen species. Reactive oxygen species (ROS), a byproduct of aerobic metabolism, are handled in the myocardium by soluble and enzymatic antioxidant systems. Oxidative stress can result from abnormally high levels of ROS production or insufficient antioxidant defenses. When the production of ROS exceeds the capacity of antioxidant defense systems, there is an increase in ‘oxidative stress’.

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Authors
  1. Douglas B. Sawyer
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  2. Wilson S. Colucci
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Editors and Affiliations

  1. Montreal Heart Institute, Research Center and Department of Medicine, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada

    Jean-Claude Tardif  & Martial G. Bourassa  & 

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© 2000 Springer Science+Business Media Dordrecht

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Sawyer, D.B., Colucci, W.S. (2000). Role of Oxidative Stress, Cytokines, and Apoptosis in Myocardial Dysfunction. In: Tardif, JC., Bourassa, M.G. (eds) Antioxidants and Cardiovascular Disease. Developments in Cardiovascular Medicine, vol 233. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4375-2_13

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  • DOI: https://doi.org/10.1007/978-94-011-4375-2_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5881-0

  • Online ISBN: 978-94-011-4375-2

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