Abstract
Various forms of injury to the central nervous system, such as in neurodegenerative diseases, sets in motion an inflammatory-like response. The messengers that accumulate are normal modulators of functions; however, above certain concentrations they trigger neuronal damage. The significance of these early warning events has recently been highlighted by the observation that patients receiving chronic treatments with certain anti-inflammatory drugs develop less severe symptoms of Alzheimer’s Disease. Cyclooxygenase-2 (COX-2) and platelet-activating factor (PAF), mediators of the inflammatory response, may thus play a role in Alzheimer’s Disease and in other neurodegenerative diseases.
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Bazan, N.G., Marcheselli, V.L., Mukherjee, P.K., Lukiw, W.J., Gordon, W.C., Zhang, D. (1998). COX-2 in brain and retina: role in neuronal survival. In: Vane, J., Botting, J. (eds) Selective COX-2 Inhibitors. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4872-6_4
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DOI: https://doi.org/10.1007/978-94-011-4872-6_4
Publisher Name: Springer, Dordrecht
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