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Lipid Deposition and Oxidation in the Evolution of the Atherosclerotic Lesion: Lessons Learned from Hypercholesterolemic Animal Models

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Multiple Risk Factors in Cardiovascular Disease

Part of the book series: Medical Science Symposia Series ((MSSS,volume 12))

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Abstract

A focus of this symposium is the potential of multifactorial approaches to managing simultaneous risk factors for prevention of atherosclerosis. In keeping with this theme, this chapter discusses how hyperlipidemia-induced increases in the deposition of lipid within the artery wall, coupled with oxidative processes occurring within the artery may play important causative roles in the pathogenesis of atherosclerosis. The data suggest that combined hypolipidemic and antioxidant therapy may be most effective in the prevention of atherosclerosis in many high risk individuals.

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Authors
  1. Michael E. Rosenfeld
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Editors and Affiliations

  1. Cornell University Medical College, 1300 York Avenue, Room F-105, New York, NY, USA

    Antonio M. Gotto Jr.

  2. National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA

    C. Lenfant

  3. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    Rodolfo Paoletti  & A. L. Catapano  & 

  4. Giovanni Lorenzini Medical Foundation, Houston, TX, USA

    A. S. Jackson

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Rosenfeld, M.E. (1998). Lipid Deposition and Oxidation in the Evolution of the Atherosclerotic Lesion: Lessons Learned from Hypercholesterolemic Animal Models. In: Gotto, A.M., Lenfant, C., Paoletti, R., Catapano, A.L., Jackson, A.S. (eds) Multiple Risk Factors in Cardiovascular Disease. Medical Science Symposia Series, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5022-4_15

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  • DOI: https://doi.org/10.1007/978-94-011-5022-4_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6108-7

  • Online ISBN: 978-94-011-5022-4

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