Abstract
Clotting factors play an important role in the pathophysiology of cardiovascular disease (CVD). In fact, plasma fibrinogen concentration is directly associated with the incidence of CVD [1], while a 1% decrease in factor VII (FVII) activity leads to a 2% reduction in the risk of death from coronary heart disease [2].
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References
Ernst E. Fibrinogen: An important risk factor for atherothrombotic diseases. Ann Med 1994;26:15–22.
Meade TW, Mellows S, Brozovic M, et al. Haemostatic function and ischaemic heart disease: Principal results of the Northwick Park Heart Study. Lancet 1986;ii:533–37.
Scarabin PY, Plu-Bureau G, Bara L, Bonithon-Kopp C, Guize L, Samama MM. Haemostatic variables and menopausal status. Influence of hormone replacement therapy. Thromb Haemost 1993;70:584–87.
Meade TW, Dyer S, Howarth DJ, Jamieson JD, Stirling Y. Antithrombin III and procoagulant activity: Sex differences and effects of the menopause. Br J Haematol 1990;74:77–81.
The writing group for the PEPI Trial. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. JAMA 1995;273:199–208.
Chetkowski RJ, Meldrum DR, Steingold KA, et al. Biological effects of transdermal estradiol. N Engl J Med 1986;314:1615–20.
Alkjaersig N, Fletcher AP, De Ziegler D, Steingold KA, Meldrum DR, Judd HL. Blood coagulation in postmenopausal women given estrogen treatment: Comparison of transdermal and oral administration. J Lab Clin Med 1988;111:224–28.
Boschetti C, Cortellaro M, Nencioni T, Bertolli V, Delia Volpe A, Zanussi C. Short-and long-term effects of hormone replacement therapy (transdermal estradiol vs oral conjugated equine estrogens, combined with medroxyprogesterone acetate) on blood coagulation factors in postmenopausal women. Thromb Res 1991;62:1–8.
Fox J, George AJ, Newton JR, et al. Effect of transdermal oestradiol on the haemostatic balance of menopausal women. Maturitas 1993;18:55–64.
Kroon U-B, Silfverstolpe G, Tengborn L. The effects of transdermal estradiol and oral conjugated estrogens on haemostasis variables. Thromb Haemost 1994;71:420–23.
The writing group for the Estradiol Clotting Factors Study. Effects on haemostasis of hormone replacement therapy with transdermal estradiol and oral sequential medroxyprogesterone acetate: A 1-year, double-blind, placebo-controlled study. Thrombosis and Haemostasis 1996;75:476–80.
Nabulsi AA, Folsom AR, White A, et al. for the Atherosclerosis Risk in Communities Study Investigators. Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. N Engl J Med 1993;328:1069–75.
Lobo AA, Pickard JH, Wild RA, Walsh B, Hirvonen E for the Menopause Study Group. Metabolic impact of adding medroxyprogesterone acetate to conjugated estrogen therapy in postmenopausal women. Obstet Gynecol 1994;84:987–95.
Daly E, Vessey MP, Hawkins MH, et al. Risk of venous thromboembolism in users of hormone replacement therapy. Lancet 1996;348:977–80.
Jick H, Derby LE, Myers MW, et al. Risk of hospital admission for idiopathic venous thromboembolism among users of postmenopausal oestrogens. Lancet 1996;348:981–83.
Grodstein F, Stampfer MJ, Goldhaber SZ, et al. Prospective study of exogenous hormones and risk of pulmonary embolism in women. Lancet 1996;348:983–87.
Meade TW, Cooper J, Miller GJ, Howarth DJ, Stirling Y. Antithrombin III and arterial disease. Lancet 1991;338:850–51.
Cortellaro M. Antithrombin III and arterial disease. Lancet 1991;338:1525–26.
Conlan MG, Folsom AR, Finch A, et al. Antithrombin III: Associations with age, race, sex and cardiovascular disease risk factors. Thromb Haemost 1994;72:551–56.
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Crosignani, P.G., Boschetti, C., Cortellaro, M., Meschia, M. (1997). Menopause, HRT, and Hemostasis. In: Paoletti, R., Crosignani, P.G., Kenemans, P., Samsioe, G., Soma, M.R., Jackson, A.S. (eds) Women’s Health and Menopause. Medical Science Symposia Series, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5560-1_15
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DOI: https://doi.org/10.1007/978-94-011-5560-1_15
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