Abstract
Charged maltodextrins gel fragments prepared on a Rannie homogeniser were studied by light scattering spectroscopy techniques and transmission electron microscopy. These fragments associate with phospholipids. The fragments/lipid association is named a Biovector and can be used as a drug delivery system or in vaccine formulations.
Light scattering reveals that the fragments are spheres with Rh≈ 50 nm. Under some experimental conditions (namely, higher ionic strengths) ρ = Rg/Rh < 0.775, suggesting that a density gradient exists at the gel fragments. This is typical of the so called “microgels” (spatially confined gels of microscopic size). The fragments’ shape and dimensions were confirmed by scanning electron microscopy.
Neutral gel fragments have a strong tendency towards large scale self-association.
The addition of phospholipids to the gel fragments results in the formation of concentric bilayers around an internal core. These cores are believed to be the gel fragments.
The Biovectors may be used to entrap hydrophilic or hydrophobic drugs, in the core or lipid bilayers respectively. Implantation of antigenic molecules on the surface might lead to new vaccine formulations.
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Castanho, M.A.R.B., Prieto, M.J.E., Betbeder, D., Santos, N.C. (1997). The Shape, Dimension and Organisation of Maltodextrins Gel Fragments with and without Associated Phospholipids. In: Pike, E.R., Abbiss, J.B. (eds) Light Scattering and Photon Correlation Spectroscopy. NATO ASI Series, vol 40. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5586-1_15
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DOI: https://doi.org/10.1007/978-94-011-5586-1_15
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