Abstract
Interrelationships between alcohohsm, malnutrition and hver disease are complex; alcohohsm commonly causes both malnutrition and liver disease, and hepatic dysfunction may be engendered by malnutrition per se. Traditionally, the disorders affecting the liver have been attributed exclusively to nutritional deficiencies accompanying alcohohsm, but recent studies, summarized here, indicate that in addition to dietary deficiencies, alcohol itself can be incriminated as a direct etiologic factor in the pathogenesis of alcohohc liver disease.
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PIROLA, R.C. and LIEBER, C.S.: The energy cost of the metabohsm of drugs, including ethanol. Pharmacology 7:185, 1972.
LINDENBAUM, J. and LIEBER, C.S.: Effects of chronic ethanol administration on intestinal absorption in man in the absence of nutritional deficiency. Ann. N.Y. Acad. Sci. 252:228, 1975.
BEST, C.H., HARTROFT, W.S., LUCAS, C.C. and RIDOUT, J.H.: Liver damage produced by feeding alcohol or sugar and its prevention by choline. Brit. Med. J. 2:1101, 1949.
LIEBER, C.S., JONES, D.P. and DECARLI, L.M.: Effects of prolonged ethanol intake: Production of fatty hver despite adequate diets. J. Clin. Invest. 44: 1009. 1965.
SHAW, S. and LIEBER, C.S.: Plasma amino acid abnormalities in the alcoholic: Respective role of alcohol, nutrition and liver injury. Gastroenterology 74:677, 1978.
LIEBER, C.S., DECARLI, L.M., GANG, H., WALKER, G. and RUBIN, E.: Hepatic effects of long term ethanol consumption in primates. In Medical Primatology 1972, (E.I. Goldsmith and J. Moor-Jankowski, Eds.) S. Karger, Basel,. Part 3, pp. 270.
LIEBER, C.S., SPRITZ, N. and DECARLI, L.M.; Fatty liver produced by dietary deficiencies: Its pathogenesis and potentiation by ethanol. J. Lipid. Res. 10:283, 1969.
LIEBER, C.S. and SPRITZ, N.: Effects of prolonged ethanol intake in man: Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J. Clin. Invest. 45:1400,1966.
LIEBER, C.S., LEFEVRE, A., SPRITZ, N., FEINMAN, L. and DECARLI, L.M.: Difference in hepatic metabolism of long- and medium-chain fatty acids: The role of fatty acid chain length in the production of the alcoholic fatty liver. J. Clin. Invest. 46:1451, 1967.
LANE, B.P. and LIEBER, C.S.: Ultrastructural alterations in human hepatocytes following ingestion of ethanol with adequate diets. Amer. J. Path. 49:593, 1966.
LIEBER, C.S. and DECARLI, L.M.: An experimental model of alcohol feeding and liver injury in the baboon. J. Med. Primatology 3:153, 1974.
LIEBER, C.S., DECARLI, L.M. and RUBIN, E.: Sequential production of fatty liver, hepatitis and cirrhosis in sub-human primates fed ethanol with adequate diets. Proc. Nat. Acad. Sci. 72:437, 1975.
PEQUIGNOT, G., TUYNS, A.J. and BERTA, J.L.: Ascitic cirrhosis in relation to alcohol consumption. International J. Epidemiology 7:113, 1978.
WILKINSON, P., SANTAMARIA, J.N. and RANKIN, J.G.: Epidemiology of alcoholic cirrhosis. Aust. Ann. Med. 18:222, 1969.
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© 1981 The AVI Publishing Company, Inc.
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Lieber, C.S. (1981). Alcohol, Malnutrition and Liver Disease. In: Barness, L.A., Coble, Y.D., MacDonald, D.I., Christakis, G. (eds) Nutrition and Medical Practice. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6695-9_22
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DOI: https://doi.org/10.1007/978-94-011-6695-9_22
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