Skip to main content
SpringerLink
Log in

Hypercalcemia of Malignancy

  • Chapter
Clinical Cancer Medicine

  • 45 Accesses

Abstract

Patients with cancer frequently have an increased serum calcium concentration. Hypercalcemia can occur at any point in the course of the disease and may be the first clue to the presence of malignancy. The condition can be clinically silent and detected only by automated multiphasic blood chemistry determinations; conversely, it can be the most debilitating aspect of the disease. The disorders of calcium homeostasis that underlie this condition are similarly varied. Fortunately, a variety of therapeutic modalities is available for patients who require reduction of their serum calcium.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ackerman, N. B., and Winer, N. The differentiation of primary hyperparathyroidism from the hypercalcemia of malignancy. Ann. Surg 181: 225–231, 1975.

    Article  Google Scholar 

  • Bassett, I. W., and Steckel, R.J. Imaging techniques in the detection of metastatic disease. Seminars in Oncology 4: 39–52, 1977.

    PubMed  CAS  Google Scholar 

  • Bender, R. A., and Hansen, H. Hypercalcemia in bronchogenic carcinoma: a prospective study of 200 patients. Ann. Intern. Med 80: 205–208, 1974.

    PubMed  CAS  Google Scholar 

  • Benson, R. C., Jr.; Riggs, B. L.; Pickard, B. M. et al. Radioimmunoassay of parathyroid hormone in hypercalcemic patients with malignant disease. Ann. Intern. Med 56: 821–826, 1974.

    Google Scholar 

  • Brereton, H. D.; Halushka, P. V.; Alexander, R. W. et al. Indomethacin-responsive hypercalcemia in a patient with renal cell adenocarcinoma. N. Engl. J. Med 291: 83–85, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Chakmakjian, Z. H., and Bethune, J. E. Sodium sulfate treatment of hypercalcemia. N. Engl. J. Med 275: 862–869, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Flower, R. J. Drugs which inhibit prosta-glandin biosynthesis. Pharmacol. Rev 26: 33–67, 1974.

    PubMed  CAS  Google Scholar 

  • Franklin, R. B., and Tashjian, A. H., Jr. Intravenous infusion of prostaglandin E2 raises plasma calcium concentration in the rat. Endocrinology 97: 140–143. 1975.

    Article  Google Scholar 

  • Fulmer, D. H.; Dimich, A. B.; Rothschild, E. O. et al. Treatment of hypercalcemia—comparison of intravenously administered phosphate, sulfate, and hydrocortisone. Arch. Intern. Med. 129: 923–930, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Gordon, G. S.; Cantino, T. J.; Erhardt, L. et al. Osteolytic sterol in human breast cancer. Science 151: 1226–1228, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., Jr.; Couranz, S. J.; and Avioli, L. V. Circulating phytosterols in normal females, lactating mothers, and breast cancer patients. J. Clin. Endocrinol. Metab. 30: 174–180, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Heath, D. A. Hypercalcemia and malignancy. Ann. Clin. Biochem 13: 555–560. 1976.

    PubMed  CAS  Google Scholar 

  • Kennedy, B. J. Mithramycin therapy in advanced testicular neoplasms. Cancer 26: 755–766, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Klein, D. C., and Raisz, L. G. Prostaglandins: stimulation of bone resorption in tissue culture. Endocrinology 86: 1436–1440, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Lafferty, F. W. Pseudohyperparathyroidism. Medicine 45: 247–260, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Levant, J. A.; Walsh, J. H.; and Isenberg, J. L. Stimulation of gastric secretion and gastrin release by single oral doses of calcium carbonate in man. N. Engl. J. Med 289: 555–558, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Lindeman, R. D., and Papper S. Therapy of fluid and electrolyte disorders. Ann. Intern. Med 82: 65–70, 1975.

    Google Scholar 

  • Lindgarde, F., and Zettervall, O. Hyper-calcemia and normal ionized serum calcium in a case of myelomatosis. Ann. Intern. Med 78: 396–399, 1973.

    PubMed  CAS  Google Scholar 

  • Mayer, G. P. Habener, J. F.; and Potts, J. T., Jr. Parathyroid hormone secretion in vivo: Demonstration of calcium-independent, nonsuppressible component of secretion. J. Clin. Invest. 57: 678–683, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Neelon, F. A. CAMP and calcemia Ann. Intern. Med 86: 821–822, 1977.

    Google Scholar 

  • Mundy, G. R. et al. Evidence for the secretion of an osteoclast stimulating factor in myeloma. N. Engl. J. Med 291: 1041–1046, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Mundy, G. R. et al. Bone-resorbing activity in supernatants from lymphoid cell lines. N. Engl. J. Med 299: 867–871, 1974.

    Article  Google Scholar 

  • Omenn, G. S.; Roth, S. L.; and Baker, W. H. Hyperparathyroidism associated with malignant tumors of non-parathyroid origin. Cancer 24: 1004–1012, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Powell, D. et al. Nonparathyroid humoral hypercalcemia in patients with neo-plastic diseases. N. Engl. J. Med. 289: 247–260, 1966.

    Google Scholar 

  • Robertson, R. P. et al. Plasma prostaglan-din E in patients with cancer with and without hypercalcemia. J. Clin. Endocrinol. Metab 43: 1330–1335, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Seyberth, H. W. et al. Prostaglandins as mediators of hypercalcemia associated with certain types of cancer. N. Engl. J. Med 293: 1278–1282, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Seyberth, H. W. et al. Characterization of the group of patients with the hypercalcemia of cancer who respond to treatment with prostaglandin synthesis inhibitors. Trans. Assoc. Am. Physicians 89: 92–104, 1976.

    PubMed  CAS  Google Scholar 

  • Shaw, J. W. et al. Urinary cyclic AMP analyzed as a function of the serum, calcium and parathyroid hormone in the differential diagnosis of hyper-calcemia. J. Clin. Invest 59: 14–21, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Silva, O. L., and Becker, K. L. Salmon calcitonin in the treatment of hyper-calcemia. Arch. Intern. Med 132: 337–339, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Tashjian, A. H., Jr. Prostaglandins, hyper-calcemia, and cancer. N. Engl. J. Med 293: 1317–1318, 1975.

    Article  PubMed  Google Scholar 

  • Tashjian, A. H., Jr. et al. Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E2—a new model for the hypercalcemia of cancer. J. Exp. Med. 136: 1329–1343, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Tashjian, A. H., Jr. et al. Successful treatment of hypercalcemia by indomethacin in mice bearing a prostaglandin-producing fibrosarcoma. Prostaglandins 3: 515–524, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Tashjian, A. H., Jr. et al. Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells. Nature 258: 739, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Vaughn, C. B., and Vaitkevicius, V. K. The effects of calcitonin in hypercalcemia in patients with malignancy. Cancer 34: 1268–1271, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Williams, R. H., ed Textbook of endocrinology. 4th ed, p. 312. Philadelphia: W. B. Saunders Co., 1968.

    Google Scholar 

Download references

Authors
  1. J. Wolff
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. New England Deaconess Hospital Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    Jacob J. Lokich M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1980 G.K. Hall & Co.

About this chapter

Cite this chapter

Wolff, J. (1980). Hypercalcemia of Malignancy. In: Lokich, J.J. (eds) Clinical Cancer Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7235-6_6

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-7235-6_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-7237-0

  • Online ISBN: 978-94-011-7235-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation