Abstract
This drug has been in use since 1952 and has outstanding, unique features in terms of low toxicity, easy absorption when given by mouth, followed by rapid diffusion throughout the body, and especially into the CSF. It also attacks tubercle bacilli in caseous or necrotic lesions and in cavities. It is very cheap. The standard adult dose for pulmonary tuberculosis is 200mg daily, which may be given as a single dose or twice daily. In miliary and meningeal tuberculosis, to achieve a high CSF concentration, the dose is increased to 12 mg/ kg /day. Effective blood levels are present for up to 24 hours after a single dose.
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References
Fox, W.: Realistic chemotherapeutic policies for tuberculosis in the developing countries. British Medical Journal 1: 135(1964).
Fox, W.: General considerations in the choice and management of regimens of chemotherapy for pulmonary tuberculosis. Bull. Un. int. Tuberc. 47: 30 (1972).
Ross, J.D. and Horne, N.W.: Modern Drug Treatment in Tuberculosis 5th Ed. (The Chest, Heart and Stroke Association) Health Horizon, London (1976).
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© 1978 ADIS Press
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Ball, A.P., Gray, J.A., Murdoch, J.M. (1978). Antituberculosis Drugs. In: Antibacterial Drugs Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8004-7_17
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DOI: https://doi.org/10.1007/978-94-011-8004-7_17
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-85200-505-7
Online ISBN: 978-94-011-8004-7
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