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Diuretics

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Clinical Nephrotoxins

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Abstract

Diuretics are among the most frequently prescribed drugs for the treatment of both edematous and non-edematous states. With respect to the latter category, they are most often utilized in the therapy of hypertension. They may injure the kidney either reversibly or irremediably, a distinction which often depends upon whether they have induced functional or anatomic damage. Ordinarily, the former type of disorder reverses more rapidly than the latter. However, anatomical lesions, for example those that may be associated with acute renal failure, may also respond to removal of the offending agent.

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References

  1. Puschett JB, Winaver J. Effects of diuretics on renal function. In: Windhager EE, editor. Handbook of physiology. Section 8 renal physiology. New York: Oxford Press, 1992: 2335–406.

    Google Scholar 

  2. Schnermann J, Wright FS, Davis JM, Stackerberg WV, Grill G. Regulation of superficial nephron filtration rate by tubuloglomerular feedback. Pflugers Arch 1970; 318: 147–75.

    Article  PubMed  CAS  Google Scholar 

  3. Thurau K, Schnermann J, Nagel W, Horster M, Wahl M. Composition of tubular fluid in the macula densa segment as a factor regulating the function of the juxtaglomerular apparatus. Circ Res 1967; 20–21 (suppl 2): 79–90.

    Google Scholar 

  4. Tucker BJ, Steiner RW, Gushwa LC, Blantz RC. Studies on the tubulo-glomerular feedback system in the rat. The mechanism of reduction in filtration rate with benzolamide. J Clin Invest 1978; 62: 993–1004.

    Article  PubMed  CAS  Google Scholar 

  5. Puschett JB, Goldberg M. The acute effects of furosemide on acid and electrolyte excretion in man. J Lab Clin Med 1968; 71: 666–77.

    PubMed  CAS  Google Scholar 

  6. Burke TJ, Duchin KL. Glomerular filtration during furosemide diuresis in the dog. Kidney Int 1979; 16: 672–80.

    Article  PubMed  CAS  Google Scholar 

  7. Hook JB, Blatt AH, Brody MJ, Williamson HE. Effects of several saluretic-diuretic agents on renal hemodynamics. J Pharmacol Exp Ther 1966; 154: 667–73.

    PubMed  CAS  Google Scholar 

  8. Vander AJ, Carlson J. Mechanism of the effects of furosemide on renin secretion in anesthetized dogs. Circ Res 1969; 25: 145–52.

    Article  PubMed  CAS  Google Scholar 

  9. Tucker BJ, Blantz RC. Effect of furosemide administration on glomerular and tubular dynamics in the rat. Kidney Int 1984; 26: 112–21.

    Article  PubMed  CAS  Google Scholar 

  10. Meyer P, Menard J, Papanicolaou N, Alexandre JM, Devaux C, Milliez P. Mechanism of renin release following furosemide diuresis in the rabbit. Am J Physiol 1968; 215: 908–15.

    PubMed  CAS  Google Scholar 

  11. Brenner BM, Keimowitz RI, Wright FS, Berliner RW. An inhibitory effect of furosemide on sodium reabsorption by the proximal tubule of the rat nephron. J Clin Invest 1969; 48: 290–300.

    Article  PubMed  CAS  Google Scholar 

  12. Burke TJ, Robinson RR, Clapp JR. Determinants of the effect of furosemide on the proximal tubule. Kidney Int 1972; 1: 12–8.

    Article  PubMed  CAS  Google Scholar 

  13. Birtch AG, Zakheim RM, Jones LG, Barger AC. Redistribution of renal blood flow produced by furosemide and ethacrynic acid. Cir Res 1967; 21: 869–78.

    Article  CAS  Google Scholar 

  14. Dluhy AG, Wolf GL, Lauler DP Vasodilator properties of ethacrynic acid in the perfused dog kidney. Clin Sci 1970; 38: 347–57.

    PubMed  CAS  Google Scholar 

  15. McNay JL, Kishimoto T. Selective renal vascular effects of ethacrynic acid. J Pharmacol Exp Ther 1970; 174: 159–68.

    PubMed  CAS  Google Scholar 

  16. Earley LE, Friedler RM. Renal tubular effects of ethacrynic acid. J Clin Invest 1964; 43: 1495–506.

    Article  PubMed  CAS  Google Scholar 

  17. Olsen UB. Indomethacin inhibition of bumetanide diuresis in dogs. Acta Pharmacol Toxicol 1975; 37: 65–78.

    Article  CAS  Google Scholar 

  18. Puschett JB, Sylk D, Teredesai PR. Uncoupling of proximal sodium bicarbonate from sodium phosphate transport by bumetanide. Am J Physiol 1978; 235 (Renal Fluid Electrolyte Physiol 4): F403–8.

    Google Scholar 

  19. Olsen UB. Prostaglandin/kinin activity related to changed renal compliance after bumetanide in dogs. Acta Pharmacol Toxicol 1977; 40: 430–8.

    CAS  Google Scholar 

  20. Olsen UB, Ahnfelt-Ronne I. Bumetanide induced increase of renal blood flow in conscious dogs and its relation to local renal hormones (PGE, kallikrein and renin). Acta Pharmacol Toxicol 1976; 38: 219–28.

    Article  CAS  Google Scholar 

  21. Olsen UB, Ahnfelt-Ronne I. Renal cortical blood redistribution after bumetanide related to heterogenicity of cortical prostaglandin metabolism in dogs. Acta Physiol Scand 1976; 97: 251–7.

    Article  PubMed  CAS  Google Scholar 

  22. Bourke E, Asbury MJA, O’Sullivan S, Gatenby PBB. The sites of action of bumetanide in man. Eur J Pharmacol 1973; 23: 283–9.

    Article  PubMed  CAS  Google Scholar 

  23. Karlander S-G, Henning R, Lundvall O. Renal effects of bumetanide, a new saluretic agent. Eur J Clin Pharmacol 1973; 6: 220–33.

    Article  PubMed  CAS  Google Scholar 

  24. Jayakumar S, Puschett JB. Study of the sites and mechanism of action of bumetanide in man. J Pharmacol Exp Ther 1977; 201: 251–8.

    PubMed  CAS  Google Scholar 

  25. Walter SJ, Laycock JF, Shirley DG. A micropuncture study of proximal tubular function after acute hydro-chlorothiazide administration to Brattleboro rats with diabetes insipidus. Clin Sci 1979; 57: 427–34.

    PubMed  CAS  Google Scholar 

  26. Krause HH, Dume T, Koch KM, Ochwadt B. Intratubularer druck, glomerularer capillardruck und glomerulum-filtrat nach furosemid und hydrochlorothiazid. Pflugers Arch 1967; 295: 80–9.

    Article  CAS  Google Scholar 

  27. Cassin S, Vogh B. Effect of hydrochlorothiazide on renal blood flow and clearance of para-aminohippurate and creatinine. Proc Soc Exp Biol Med 1966; 122: 970–3.

    Article  PubMed  CAS  Google Scholar 

  28. Councilman WT. Acute interstitial nephritis. J Exp Med 1898; 3: 393–420.

    Article  PubMed  CAS  Google Scholar 

  29. Bakken K. The allergic reaction of the kidney to sulphonamide medication. J Pathol Bacteriol 1947; 59: 501–4.

    Article  Google Scholar 

  30. Baldwin DS, Levine BB, McCluskey RT, Gallo GR. Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med 1968; 279: 1245–52.

    Article  PubMed  CAS  Google Scholar 

  31. Simenhoff ML, Guild WR, Dammin GJ. Acute diffuse interstitial nephritis: review of the literature and case report. Am J Med 1968; 44: 618–25.

    Article  PubMed  CAS  Google Scholar 

  32. Lyons H, Pinn VW, Cortell S, Cohen JJ, Harrington JT. Allergic interstitial nephritis causing reversible renal failure in four patients with idiopathic nephrotic syndrome. N Engl J Med 1973; 288: 124–8.

    Article  PubMed  CAS  Google Scholar 

  33. Fialk MA, Romankiewicz J, Perrone F, Sherman RL. Allergic interstitial nephritis with diuretics. Ann Intern Med 1974; 81: 403–4.

    Article  PubMed  CAS  Google Scholar 

  34. Fuller TJ, Barcenas CG, White MG. Diuretic-induced interstitial nephritis. JAMA 1976; 235: 1998–9.

    Article  PubMed  CAS  Google Scholar 

  35. Magil AB, Ballon HS, Cameron EG, Rae A. Acute interstitial nephritis associated with thiazide diuretics. Am J Med 1980; 69: 939–43.

    Article  PubMed  CAS  Google Scholar 

  36. Bailey RR, Lynn KL, Drennan CJ, Turner GAL. Triamterene-induced acute interstitial nephritis. Lancet 1982; 1: 226.

    Article  PubMed  CAS  Google Scholar 

  37. Roy LF, Villeneuve J-P, Dumont A, Dufresne LR, Duran MA, Morin C, Jobin J. Irreversible renal failure associated with triamterene. Am J Nephrol 1991; 11(6): 486–8.

    Article  PubMed  CAS  Google Scholar 

  38. Peskoe ST, McMillan JH, Lorch A, Sussman H, Ozawa T. Reversible acute renal failure associated with chlorthalidone therapy: possible drug-induced interstitial nephritis. J Med Assoc Ga 1978; 67: 17–8.

    PubMed  CAS  Google Scholar 

  39. Ooi BS, Jao W, First MR, Mancilla R, Pollak VE. Acute interstitial nephritis. A clinical and pathologic study based on renal biopsies. Am J Med 1975; 59: 614–28.

    Article  PubMed  CAS  Google Scholar 

  40. Walker RG, Whitworth JA, Kincaid-Smith PS. Acute interstitial nephritis in a patient taking tienilic acid. Brit Med J 1980; 280: 1212.

    Article  PubMed  CAS  Google Scholar 

  41. Newstead CG, Moore RH, Barnes AJ. Interstitial nephritis associated with indapamide. Brit Med J 1990; 300: 1344.

    Article  PubMed  CAS  Google Scholar 

  42. Pusey CD, Saltissi D, Bloodworm L, Rainford DJ, Christie JL. Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy. Q J Med 1983; 52: 194–211.

    PubMed  CAS  Google Scholar 

  43. Ten RM, Torres VE, Milliner DW, Schwab TR, Holley KE, Gleich GJ. Acute interstitial nephritis: immunologic and clinical aspects. Mayo Clin Proc 1988; 63: 921–30.

    Article  PubMed  CAS  Google Scholar 

  44. Kleinknecht D, Vanhille Ph, Morel-Maroger L, Kanfer A, Lemaitre V, Mery JP, Laederich J, Callard P. Acute interstitial nephritis due to drug hypersensitivity. An up-to-date review with a report of 19 cases. Adv Nephrol 1983; 12: 277–308.

    CAS  Google Scholar 

  45. Bennett WM. Diuretic toxicity and drug interactions. In: Dirks JH, Sutton RAL, editors. Diuretics: physiology, pharmacology and clinical use. Philadelphia: WB Saunders, 1986: 362–73.

    Google Scholar 

  46. Grünfeld J-P, Kleinknecht D, Droz D. Acute interstitial nephritis. In: Schrier RW, Gottschalk CW, editors. Diseases of the kidney, 4th ed. Boston: Little Brown, 1988: 1461–87.

    Google Scholar 

  47. Magil AB. Drug-induced acute interstitial nephritis with granulomas. Hum Pathol 1983; 13: 36–41.

    Article  Google Scholar 

  48. Larsson GB, Langer L, Nässberger L. Thiazide-induced kidney damage with circulating antibodies against myeloperoxidase and cardiolipin. J Intern Med 1993; 233: 493–4.

    Article  PubMed  CAS  Google Scholar 

  49. Bjornberg A, Gesslen H. Thiazides: a cause of necrotizing vasculitis. Lancet 1965; 2: 982.

    Article  PubMed  CAS  Google Scholar 

  50. Grunwald MH, Halevy S, Livni E. Allergic vasculitis induced by hydrochlorothiazide: confirmation by mast cell degranulation test. Isr J Med Sci 1989; 25: 572–4.

    PubMed  CAS  Google Scholar 

  51. Reed BR, Huff JC, Jones SK, Orton PW, Lee LA, Norris PA. Subacute cutaneous lupus erythematosis associated with hydrochlorothiazide treatment. Ann Intern Med 1985; 103: 49–51.

    Article  PubMed  CAS  Google Scholar 

  52. Fitzgerald EW. Fatal glomerulonephritis complicating allergic purpura due to chlorothiazide. Arch Intern Med 1960; 105: 305–10.

    Article  PubMed  Google Scholar 

  53. Kjellbo H, Stakeberg H, Mellgren J. Possibly thiazide-induced renal necrotizing vasculitis. Lancet 1965; 2: 1034–5.

    Article  Google Scholar 

  54. Cox NH, Hodkin P. Vasculitis due to metolazone. Postgrad Med J 1991; 67: 860.

    Article  PubMed  CAS  Google Scholar 

  55. Howlett SA. Renal failure associated with acetazolamide therapy for glaucoma. South Med J 1975; 68: 504–6.

    Article  PubMed  CAS  Google Scholar 

  56. West AE. Hematuria in acetazolamide (Diamox) therapy. Crit Care Med 1982; 10: 197.

    Article  PubMed  CAS  Google Scholar 

  57. Higenbottam T, Ogg CS, Saxton HM. Acute renal failure from the use of acetazolamide (Diamox). Postgrad Med J 1978; 54: 127–8.

    Article  PubMed  CAS  Google Scholar 

  58. Glustien AS, Fisher ER. Renal lesions of sulfonamide type after treatment with acetazolamide (Diamox). JAMA 1956; 160: 204–6.

    Article  Google Scholar 

  59. Bertino JR, Rodman T, Myerson RM. Thrombocytopenia and renal lesions associated with acetazolamide (Diamox) therapy. Arch Intern Med 1957; 99: 1006–8.

    Article  CAS  Google Scholar 

  60. Orchard RT, Taylor DJE, Parkins RA. Sulphonamide crystalluria with acetazolemide. Brit Med J 1972; 3: 646.

    Article  PubMed  CAS  Google Scholar 

  61. Yates-Bell JG. Renal colic and anuria from acetazolamide. Brit Med J 1958; 2: 1392.

    Article  PubMed  CAS  Google Scholar 

  62. Persky L, Chambers D, Potts A. Calculus formation and ureteral colic following acetazolamide (Diamox) therapy. JAMA 1956; 161: 1625–6.

    Article  CAS  Google Scholar 

  63. Parfitt AM. Acetazolamide and sodium bicarbonate induced nephrocalcinosis and nephrolithiasis. Arch Intern Med 1969; 124: 736–40.

    Article  PubMed  CAS  Google Scholar 

  64. Davis DW. Acetazolamide therapy with renal complications. Brit Med J 1959; 1: 214–5.

    Article  Google Scholar 

  65. Gordon EE, Sheps SG. Effect of acetazolamide on citrate excretion and formation of renal calculi. N Engl J Med 1957; 256: 1215–9.

    Article  PubMed  CAS  Google Scholar 

  66. Mackenzie AR. Acetazolamide-induced renal stone. J Urol 1960; 84: 453–5.

    PubMed  CAS  Google Scholar 

  67. Leopold IH. Ureteric calculi due to long-term use of carbonic anhydrase inhibitors. JAMA 1968; 208: 538.

    Google Scholar 

  68. Ettinger B, Weil E, Mandel NS, Darling S. Triamterene-induced nephrolithiasis. Ann Intern Med 1979; 91: 745–6.

    Article  PubMed  CAS  Google Scholar 

  69. Ettinger B, Oldroyd NO, Sorgel F. Triamterene nephrolithiasis. JAMA 1980; 244: 2443–5.

    Article  PubMed  CAS  Google Scholar 

  70. DeMartini FE, Wheaton EA, Healey LA, Larugh JH. Effect of chlorothiazide on renal excretion of uric acid. Am J Med 1962; 32: 572–7.

    Article  Google Scholar 

  71. Puschett JB. Clinical uses of diuretics. In: Greger R, Knauf H, Mutschier E, editors. Handbook of experimental pharmacology. Diuretics. Berlin: Springer-Verlag, (in press).

    Google Scholar 

  72. Steele TH. Importance and pathogenesis of diuretic-induced hyperuremia. In: Puschett JB, Greenberg A, editors. Diuretics IV. Chemistry, pharmacology and clinical applications. Amsterdam: Elsevier, 1993: 231–8.

    Google Scholar 

  73. Carlsen JE, Kober L, Torp-Pedersen C, Johansen P. Relation between dose of bendrofluazide, anti-hypertensive effect, and adverse biochemical effects. Br Med J 1990; 300: 975–8.

    Article  CAS  Google Scholar 

  74. Berglund G, Ansersson O.Low doses of hydrochlorothiazide in hypertension. Antihypertensive and metabolic effects. Eur J Pharmacol 1976; 10: 177–82.

    Article  Google Scholar 

  75. Liang MH, Fries JF. Asymptomatic hyperuricemia: the case for conservative management. Ann Intern Med 1978; 88: 666–70.

    Article  PubMed  CAS  Google Scholar 

  76. Hall AP, Barney PE, Dawber TR, McNamara PM. Epidemiology of gout and hyperuricemia. A long-term population study. Am J Med 1967; 42: 27–37.

    Article  PubMed  CAS  Google Scholar 

  77. Gutman AB, Yü TF. Renal function and gout with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout. Am J Med 1957; 23: 600–22.

    Article  PubMed  CAS  Google Scholar 

  78. Fessel WJ, Siegelaub AB, Johnson ES. Correlation and consequences of asymptomatic hyperuricemia. Arch Intern Med 1973; 132: 44–54.

    Article  PubMed  CAS  Google Scholar 

  79. Fessel WJ. Renal outcomes of gout and hyperuricemia. Am J Med 1979; 67: 74–82.

    Article  PubMed  CAS  Google Scholar 

  80. Klinenberg JR, Gonick HC, Dornfeld L. Renal function abnormalities in patients with asymptomatic hyperuricemia. Arthritis Rheum 1975; 18 (suppl): 725–30.

    Article  PubMed  CAS  Google Scholar 

  81. Briney WG, Ogden D, Bartholomew B, Smythe CJ. The influence of allopurinol on renal function in gout. Arthritis Rheum 1975; 18 (suppl): 877–81.

    Article  PubMed  CAS  Google Scholar 

  82. Berger L, Yü TF. Renal function in gout IV An analysis of 524 gouty subjects including long-term follow-up studies. Am J Med 1975; 59: 605–13.

    Article  PubMed  CAS  Google Scholar 

  83. Rosenfeld JB. Effect of long-term allopurinol administration on serial GFR in normotensive and hypertensive hyperuricemic subjects. Adv Exp Med Biol 1974; 41: 581–96.

    Article  PubMed  CAS  Google Scholar 

  84. Steele TH, Manuel MA, Boner G. Diuretics, urate excretion and sodium reabsorption: effect of acetazolamide and urinary alkalinization. Nephron 1975; 14: 48–61.

    Article  Google Scholar 

  85. Puschett JB, O’Donovan R. Renal actions and uses of diuretics. In: Massry SG, Glassock RJ, editors. Textbook of nephrology. Baltimore: Williams & Wilkins (in press).

    Google Scholar 

  86. Puschett JB, Rastegar A. Comparative study of the effects of metolazone and other diuretics on potassium excretion. Clin Pharmacol Ther 1973; 15: 397–405.

    Google Scholar 

  87. Giebisch G. Effect of diuretics on renal transport of potassium. Methods Pharmacol 1976; 4A: 121–64.

    Article  Google Scholar 

  88. Wright FS, Giebisch G. Regulation of potassium excretion. In: Seldin DW, Giebisch G, editors. The kidney: physiology and pathophysiology. New York: Raven Press, 1992: 2206–47.

    Google Scholar 

  89. Lawson DH. Allergic reaction to potassium chloride. Q J Med 1974; 43: 443–50.

    Google Scholar 

  90. Kassirer JP, Harrington JT. Diuretics and potassium metabolism: a reassessment of the need, effectiveness and safety of potassium therapy. Kidney Int 1977; 11: 505–15.

    Article  PubMed  CAS  Google Scholar 

  91. Cremer W, Bock KD. Symptoms and course of chronic hypokalemic nephropathy in man. Clin Nephrol 1977; 7: 112–9.

    PubMed  CAS  Google Scholar 

  92. O’Donovan RA, Muhammedi M, Puschett JB. Diuretics in the therapy of hypertension: current status. Am J Med Sci 1992; 304: 312–8.

    Article  PubMed  Google Scholar 

  93. Conn JW, Johnson RD. Kaliopenic nephropathy. Am J Clin Nutr 1956; 4: 523–8.

    PubMed  CAS  Google Scholar 

  94. Relman AS, Schwartz WB. The kidney in potassium depletion. Am J Med 1958; 24: 764–73.

    Article  PubMed  CAS  Google Scholar 

  95. Cremer W, Blümcke S, Bock KD. Morphologie der kaliopenischen nephropathie beim menschen. Zentrabi Allg Path 1974; 118: 481–2.

    Google Scholar 

  96. Healy JJ, McKenna TJ, Canning B St J, Brien TG, Duffy GJ, Muldowney FP. Body composition changes in hypertensive subjects on long-term oral diuretic therapy. Brit Med J 1970; 1: 716–9.

    Article  PubMed  CAS  Google Scholar 

  97. Mujais SK, Katz AI. Potassium deficiency. In: Seldin DW, Giebisch G, editors. The kidney: physiology and pathophysiology. New York: Raven Press, 1992: 2249–78.

    Google Scholar 

  98. Kirk KL, Schaefer JA. Water transport and osmoregulation by antidiuretic hormone in terminal nephron segments. In: Seldin DW, Giebisch G, editors. The kidney: physiology and pathophysiology. New York: Raven Press, 1992: 1693–725.

    Google Scholar 

  99. Orloff J, Handler JS. The similarity of effects of vasopressin adenosine-3′, 5′-monophosphate (cyclic AMP) and theophylline on the toad bladder. J Clin Invest 1962; 41: 702–9.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Jules B. Puschett
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Editors and Affiliations

  1. Division of Nephrology and Hypertension, University of Antwerp, Belgium

    M. E. De Broe  & G. A. Verpooten  & 

  2. Department of Medicine, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    G. A. Porter

  3. Division of Nephrology, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    W. M. Bennett

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Puschett, J.B. (1998). Diuretics. In: De Broe, M.E., Porter, G.A., Bennett, W.M., Verpooten, G.A. (eds) Clinical Nephrotoxins. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9088-4_18

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  • DOI: https://doi.org/10.1007/978-94-015-9088-4_18

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