Abstract
In this chapter we describe a variety of syndromic obesities. These are distinct obesities characterized by a specific phenotypic pattern and in many cases a single specific genetic cause. In some cases, the specific genes involved have been discovered and provide insights into both potential treatments for afflicted individuals and the mechanisms which underlie body weight regulation. The known obesity syndromes include dominant and recessive modes of inheritance, polygenic obesities and imprinted genetic transmission. Comparisons between selected animal modes of obesity and human obesity syndromes are presented. These comparisons illustrate the important cross-species effects of certain genes, point out potential candidate genes with as yet undemonstrated roles in human obesity, and highlight possible physiological pathways for further investigation in human obesity studies.
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Bray, M.S., Allison, D.B. (2001). Obesity Syndromes. In: Owen, J.B., Treasure, J.L., Collier, D.A. (eds) Animal Models — Disorders of Eating Behaviour and Body Composition. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9662-6_1
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DOI: https://doi.org/10.1007/978-94-015-9662-6_1
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